A systematic optimization of 19F MR image acquisition to detect macrophage invasion into an ECM hydrogel implanted in the stroke-damage brain

Publication date: Available online 10 August 2019Source: NeuroImageAuthor(s): Harmanvir Ghuman, T. Kevin Hitchens, Michel ModoAbstract19F-MR imaging of perfluorocarbon (PFC)-labeled macrophages can provide a unique insight into their participation and spatio-temporal dynamics of inflammatory events, such as the biodegradation of an extracellular matrix (ECM) hydrogel implanted into a stroke cavity. To determine the most efficient acquisition strategy for 19F-MR imaging, five commonly used sequences were optimized using a design of experiment (DoE) approach and compared based on their signal-to-noise ratio (SNR). The fast imaging with steady-state precession (FISP) sequence produced the most efficient detection of a19F signal followed by the rapid acquisition with relaxation enhancement (RARE) sequence. The multi-slice multi-echo (MSME), fast low angle shot (FLASH), and zero echo time (ZTE) sequences were significantly less efficient. Imaging parameters (matrix/voxel size; slice thickness, number of averages) determined the accuracy (i.e. trueness and precision) of object identification by reducing partial volume effects, as determined by analysis of the point spread function (PSF). A 96 × 96 matrix size (0.35 mm3) produced the lowest limit of detection (LOD) for RARE (2.85 mM PFPE; 119 mM 19F) and FISP (0.43 mM PFPE; 18.1 mM 19F), with an SNR of 2 as the detection threshold. Imaging of a brain phantom with PFC-labeled macrophages invading an ECM hydrogel f...
Source: NeuroImage - Category: Neuroscience Source Type: research

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Publication date: Available online 28 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Luis Weitbrecht, Daniel Berchtold, Tian Zhang, Sandra Jagdmann, Claudia Dames, Katarzyna Winek, Christian Meisel, Andreas Meisel
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Authors: Béjot Y PMID: 32981687 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Authors: Smadja D, Salmon PK Abstract Health professionals are currently facing the challenge of managing an increasing number of old patients presenting with acute stroke, due to rapid aging of the population. Compared to their younger counterparts, elderly patients differ in many ways in the setting of acute stroke. Apart from a striking high stroke incidence, which increases exponentially as age increases, cardioembolism also becomes, as patients age, the main cause of ischemic stroke. Delirium, which can challenge the diagnosis, is frequent at the acute phase of stroke, and may be related to an underlying demen...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Publication date: Available online 28 September 2020Source: Pharmacology &TherapeuticsAuthor(s): Tao Tao, Maozhu Liu, Mengyuan Chen, Ying Luo, Cheng Wang, Tongtong Xu, Yixu Jiang, Yiyan Guo, John H. Zhang
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
An artificial intelligence algorithm can be extremely sensitive for detecting...Read more on AuntMinnie.comRelated Reading: SIIM 2020: How to create robust radiology AI algorithms SIIM 2020: Human element shouldn't be neglected with AI Gender imbalance in AI training datasets lowers results Collaboration yields brain CT hemorrhage dataset Could imaging AI research be endangering patients?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Authors: Zhang P, Zou JZ, Chen J, Tan X, Xiang FF, Shen B, Hu JC, Wang JL, Wang YQ, Yu JB, Nie YX, Chen XH, Yu JW, Zhang Z, Lv WL, Xie YQ, Cao XS, Ding XQ Abstract BACKGROUND: Trimethylamine-N-Oxide (TMAO) is a proatherogenic and prothrombotic metabolite. Our study examined the association of plasma TMAO level with cardiovascular and all-cause mortality in hemodialysis (HD) patients. METHODS: Patients who were at least 18 years-old and received HD for at least 6 months were enrolled within 6 months. Patients with coronary heart disease, congestive heart failure, arrhythmia, or stroke within...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Conditions:   Stroke;   Physical Disability Interventions:   Device: real stimulation;   Device: No stimulation Sponsors:   Medical University of South Carolina;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Stroke;   Balance; Distorted Interventions:   Diagnostic Test: mini-BESTest (Mini-Balance Evaluation Systems Test);   Diagnostic Test: Berg Balance Scale;   Diagnostic Test: Timed Up and Go Test;   Diagnostic Test: Functional Reach Test Sponsor:   Istanbul Medeniyet University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: CAVI independently predicts stroke in patients with HF.The trial registration number: UMIN000029132. PMID: 32981919 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
CONCLUSIONS: The the low methodological quality and small number of studies means current evidence provides limited clinical guidance. Clearly more research is needed to inform care: researchers must improve the methodological quality of studies, plus fully consider and report the aspects of attention and function addressed in their work. PMID: 32986625 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
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