Filtered By:
Source: Neuropsychologia
This page shows you your search results in order of relevance. This is page number 7.
Order by Relevance | Date
Total 127 results found since Jan 2013.
The anatomy of apathy: a neurocognitive framework for amotivated behavior
Publication date: Available online 8 July 2017 Source:Neuropsychologia Author(s): C. Le Heron, M.A.J. Apps., M. Husain Apathy is a debilitating syndrome associated with many neurological disorders, including several common neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, and focal lesion syndromes such as stroke. Here, we review neuroimaging studies to identify anatomical correlates of apathy, across brain disorders. Our analysis reveals that apathy is strongly associated with disruption particularly of dorsal anterior cingulate cortex (dACC), ventral striatum (VS) and connected brain region...
Source: Neuropsychologia - July 8, 2017 Category: Neurology Source Type: research
Reshaping the brain after stroke: the effect of prismatic adaptation in patients with right brain damage
Publication date: Available online 4 August 2017 Source:Neuropsychologia Author(s): Sonia Crottaz-Herbette, Eleonora Fornari, Michael P. Notter, Claire Bindschaedler, Laura Manzoni, Stephanie Clarke Prismatic adaptation has been repeatedly reported to alleviate neglect symptoms; in normal subjects, it was shown to enhance the representation of the left visual space within the left inferior parietal cortex. Our study aimed to determine in humans whether similar compensatory mechanisms underlie the beneficial effect of prismatic adaptation in neglect. Fifteen patients with right hemispheric lesions and 11 age-matched contro...
Source: Neuropsychologia - August 7, 2017 Category: Neurology Source Type: research
Semantic control deficits impair understanding of thematic relationships more than object identity
Publication date: Available online 11 August 2017 Source:Neuropsychologia Author(s): Hannah Thompson, James Davey, Paul Hoffman, Glyn Hallam, Rebecca Kosinski, Sarah Howkins, Emma Wooffindin, Rebecca Gabbitas, Elizabeth Jefferies Recent work has suggested a potential link between the neurocognitive mechanisms supporting the retrieval of events and thematic associations (i.e., knowledge about how concepts relate in a meaningful context) and semantic control processes that support the capacity to shape retrieval to suit the circumstances. Thematic associations and events are inherently flexible: the meaning of an item chang...
Source: Neuropsychologia - August 11, 2017 Category: Neurology Source Type: research
Corrections for multiple comparisons in voxel-based lesion-symptom mapping
Publication date: Available online 26 August 2017 Source:Neuropsychologia Author(s): Daniel Mirman, Jon-Frederick Landrigan, Spiro Kokolis, Sean Verillo, Casey Ferrara, Dorian Pustina Voxel-based lesion-symptom mapping (VLSM) is an important method for basic and translational human neuroscience research. VLSM leverages modern neuroimaging analysis techniques to build on the classic approach of examining the relationship between location of brain damage and cognitive deficits. Testing an association between deficit severity and lesion status in each voxel involves very many individual tests and requires statistical correct...
Source: Neuropsychologia - August 27, 2017 Category: Neurology Source Type: research
Improved accuracy of lesion to symptom mapping with multivariate sparse canonical correlations
In this study, we propose a multivariate optimization technique known as sparse canonical correlation analysis for neuroimaging (SCCAN) for lesion to symptom mapping. To validate the method and compare it with mass-univariate results, we used data from 131 patients with chronic stroke lesions in the territory of the middle cerebral artery, and created synthetic behavioral scores based on the lesion load of 93 brain regions (putative functional units). LSM analyses were performed with univariate VLSM or SCCAN, and the accuracy of the two methods was compared in terms of both overlap and and displacement from the simulated f...
Source: Neuropsychologia - September 5, 2017 Category: Neurology Source Type: research
Neural correlates of improvements in personality and behavior following a neurological event
Publication date: Available online 21 November 2017 Source:Neuropsychologia Author(s): Marcie L. King, Kenneth Manzel, Joel Bruss, Daniel Tranel Research on changes in personality and behavior following brain damage has focused largely on negative outcomes, such as increased irritability, moodiness, and social inappropriateness. However, clinical observations suggest that some patients may actually show positive personality and behavioral changes following a neurological event. In the current work, we investigated neuroanatomical correlates of positive personality and behavioral changes following a discrete neurological e...
Source: Neuropsychologia - November 23, 2017 Category: Neurology Source Type: research
Does it fit? - Impaired affordance perception after stroke
Publication date: Available online 2 December 2017 Source:Neuropsychologia Author(s): Jennifer Randerath, Lisa Finkel, Cheryl Shigaki, Joe Burris, Ashish Nanda, Peter Hwang, Scott H. Frey
Source: Neuropsychologia - December 3, 2017 Category: Neurology Source Type: research
The structure of the mental lexicon: what primary progressive aphasias reveal
Publication date: Available online 11 December 2017 Source:Neuropsychologia Author(s): Clara Sanches, Alexandre Routier, Olivier Colliot, Marc Teichmann Like recursive syntax, a structured mental lexicon is specific to the human species but its internal organization remains unclear. It is thought to contain information about the semantic, syntactic (e.g., gender) and formal (orthographic/phonological) features of a word. Previous studies suggested that these three components might be separated at the behavioral level and that they might be implemented by temporal cortices. However, the available investigations are based o...
Source: Neuropsychologia - December 11, 2017 Category: Neurology Source Type: research
The Spatial Distribution of Perseverations in Neglect Patients during a Nonverbal Fluency Task Depends on the Integrity of the Right Putamen
Publication date: Available online 31 January 2018 Source:Neuropsychologia Author(s): B.C. Kaufmann, J. Frey, T. Pflugshaupt, P. Wyss, R.E. Paladini, T. Vanbellingen, S. Bohlhalter, M. Chechlacz, T. Nef, R.M. Müri, D. Cazzoli, T. Nyffeler Deficient inhibitory control leading to perseverative behaviour is often observed in neglect patients. Previous studies investigating the relationship between response inhibition and visual attention have reported contradictory results: some studies found a linear relationship between neglect severity and perseverative behaviour whereas others could not replicate this result. The aim of...
Source: Neuropsychologia - January 31, 2018 Category: Neurology Source Type: research
The neuroimaging basis of apathy: Empirical findings and conceptual challenges
Publication date: Available online 2 February 2018 Source:Neuropsychologia Author(s): Sergio E. Starkstein, Simone Brockman Apathy, usually defined as loss of motivation, is common in both neurodegenerative conditions such as Alzheimer's disease, and acute neurological disorders such as stroke. Neuroradiological studies on the imaging correlates of apathy have used a variety of methods such as structural and functional magnetic resonance imaging, diffusion tensor imaging, and single photon and positron emission tomography to assess brain metabolic activity and specific synaptic receptors. Dysfunction of the anterior cingu...
Source: Neuropsychologia - February 2, 2018 Category: Neurology Source Type: research
How distributed processing produces false negatives in voxel-based lesion-deficit analyses
In this study, we hypothesized that if the same deficit can be caused by damage to one or another part of a distributed neural system, then voxel-based analyses might miss critical lesion sites because preservation of each site will not be consistently associated with preserved function. The first part of our investigation used voxel-based multiple regression analyses of data from 359 right-handed stroke survivors to identify brain regions where lesion load is associated with picture naming abilities after factoring out variance related to object recognition, semantics and speech articulation so as to focus on deficits ari...
Source: Neuropsychologia - March 3, 2018 Category: Neurology Source Type: research
Neural Mechanisms of Two Different Verbal Working Memory Tasks: A VLSM Study
Publication date: Available online 8 March 2018 Source:Neuropsychologia Author(s): M.V. Ivanova, O.V. Dragoy, S.V. Kuptsova, S. Akinina Yu., A.G. Petrushevskii, O.N. Fedina, A. Turken, V.M. Shklovsky, N.F. Dronkers Currently, a distributed bilateral network of frontal-parietal areas is regarded as the neural substrate of working memory (WM), with the verbal WM network being more left-lateralized. This conclusion is based primarily on functional magnetic resonance imaging (fMRI) data that provides correlational evidence for brain regions involved in a task. However, fMRI cannot differentiate the areas that are fundamentall...
Source: Neuropsychologia - March 9, 2018 Category: Neurology Source Type: research
The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings
This study investigated how sample size affects the reproducibility of findings from univariate voxel-based lesion-deficit analyses (e.g., voxel-based lesion-symptom mapping and voxel-based morphometry). Our effect of interest was the strength of the mapping between brain damage and speech articulation difficulties, as measured in terms of the proportion of variance explained. First, we identified a region of interest by searching on a voxel-by-voxel basis for brain areas where greater lesion load was associated with poorer speech articulation using a large sample of 360 right-handed English-speaking stroke survivors. We t...
Source: Neuropsychologia - March 15, 2018 Category: Neurology Source Type: research
Improved accuracy of lesion to symptom mapping with multivariate sparse canonical correlations
In this study, we propose a multivariate optimization technique known as sparse canonical correlation analysis for neuroimaging (SCCAN) for lesion to symptom mapping. To validate the method and compare it with mass-univariate results, we used data from 131 patients with chronic stroke lesions in the territory of the middle cerebral artery, and created synthetic behavioral scores based on the lesion load of 93 brain regions (putative functional units). LSM analyses were performed with univariate VLSM or SCCAN, and the accuracy of the two methods was compared in terms of both overlap and displacement from the simulated funct...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
How distributed processing produces false negatives in voxel-based lesion-deficit analyses
In this study, we hypothesized that if the same deficit can be caused by damage to one or another part of a distributed neural system, then voxel-based analyses might miss critical lesion sites because preservation of each site will not be consistently associated with preserved function. The first part of our investigation used voxel-based multiple regression analyses of data from 359 right-handed stroke survivors to identify brain regions where lesion load is associated with picture naming abilities after factoring out variance related to object recognition, semantics and speech articulation so as to focus on deficits ari...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
