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Source: Neuropsychologia
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Total 127 results found since Jan 2013.
Corrections for multiple comparisons in voxel-based lesion-symptom mapping
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): Daniel Mirman, Jon-Frederick Landrigan, Spiro Kokolis, Sean Verillo, Casey Ferrara, Dorian PustinaAbstractVoxel-based lesion-symptom mapping (VLSM) is an important method for basic and translational human neuroscience research. VLSM leverages modern neuroimaging analysis techniques to build on the classic approach of examining the relationship between location of brain damage and cognitive deficits. Testing an association between deficit severity and lesion status in each voxel involves very many individual tests and requires statistical correction...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings
This study investigated how sample size affects the reproducibility of findings from univariate voxel-based lesion-deficit analyses (e.g., voxel-based lesion-symptom mapping and voxel-based morphometry). Our effect of interest was the strength of the mapping between brain damage and speech articulation difficulties, as measured in terms of the proportion of variance explained. First, we identified a region of interest by searching on a voxel-by-voxel basis for brain areas where greater lesion load was associated with poorer speech articulation using a large sample of 360 right-handed English-speaking stroke survivors. We t...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
The spatial distribution of perseverations in neglect patients during a nonverbal fluency task depends on the integrity of the right putamen
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): B.C. Kaufmann, J. Frey, T. Pflugshaupt, P. Wyss, R.E. Paladini, T. Vanbellingen, S. Bohlhalter, M. Chechlacz, T. Nef, R.M. Müri, D. Cazzoli, T. NyffelerAbstractDeficient inhibitory control leading to perseverative behaviour is often observed in neglect patients. Previous studies investigating the relationship between response inhibition and visual attention have reported contradictory results: some studies found a linear relationship between neglect severity and perseverative behaviour whereas others could not replicate this result. The aim of the...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
Neural mechanisms of two different verbal working memory tasks: A VLSM study
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): M.V. Ivanova, O. Dragoy, S.V. Kuptsova, S. Yu. Akinina, A.G. Petrushevskii, O.N. Fedina, A. Turken, V.M. Shklovsky, N.F. DronkersAbstractCurrently, a distributed bilateral network of frontal-parietal areas is regarded as the neural substrate of working memory (WM), with the verbal WM network being more left-lateralized. This conclusion is based primarily on functional magnetic resonance imaging (fMRI) data that provides correlational evidence for brain regions involved in a task. However, fMRI cannot differentiate the areas that are fundamentally ...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
The spatial distribution of perseverations in neglect patients during a nonverbal fluency task depends on the integrity of the right putamen
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): B.C. Kaufmann, J. Frey, T. Pflugshaupt, P. Wyss, R.E. Paladini, T. Vanbellingen, S. Bohlhalter, M. Chechlacz, T. Nef, R.M. Müri, D. Cazzoli, T. NyffelerAbstractDeficient inhibitory control leading to perseverative behaviour is often observed in neglect patients. Previous studies investigating the relationship between response inhibition and visual attention have reported contradictory results: some studies found a linear relationship between neglect severity and perseverative behaviour whereas others could not replicate this result. The aim of the...
Source: Neuropsychologia - July 10, 2018 Category: Neurology Source Type: research
Neural mechanisms of two different verbal working memory tasks: A VLSM study
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): M.V. Ivanova, O. Dragoy, S.V. Kuptsova, S. Yu. Akinina, A.G. Petrushevskii, O.N. Fedina, A. Turken, V.M. Shklovsky, N.F. DronkersAbstractCurrently, a distributed bilateral network of frontal-parietal areas is regarded as the neural substrate of working memory (WM), with the verbal WM network being more left-lateralized. This conclusion is based primarily on functional magnetic resonance imaging (fMRI) data that provides correlational evidence for brain regions involved in a task. However, fMRI cannot differentiate the areas that are fundamentally ...
Source: Neuropsychologia - July 10, 2018 Category: Neurology Source Type: research
Improved accuracy of lesion to symptom mapping with multivariate sparse canonical correlations
In this study, we propose a multivariate optimization technique known as sparse canonical correlation analysis for neuroimaging (SCCAN) for lesion to symptom mapping. To validate the method and compare it with mass-univariate results, we used data from 131 patients with chronic stroke lesions in the territory of the middle cerebral artery, and created synthetic behavioral scores based on the lesion load of 93 brain regions (putative functional units). LSM analyses were performed with univariate VLSM or SCCAN, and the accuracy of the two methods was compared in terms of both overlap and displacement from the simulated funct...
Source: Neuropsychologia - July 10, 2018 Category: Neurology Source Type: research
How distributed processing produces false negatives in voxel-based lesion-deficit analyses
In this study, we hypothesized that if the same deficit can be caused by damage to one or another part of a distributed neural system, then voxel-based analyses might miss critical lesion sites because preservation of each site will not be consistently associated with preserved function. The first part of our investigation used voxel-based multiple regression analyses of data from 359 right-handed stroke survivors to identify brain regions where lesion load is associated with picture naming abilities after factoring out variance related to object recognition, semantics and speech articulation so as to focus on deficits ari...
Source: Neuropsychologia - July 10, 2018 Category: Neurology Source Type: research
Corrections for multiple comparisons in voxel-based lesion-symptom mapping
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): Daniel Mirman, Jon-Frederick Landrigan, Spiro Kokolis, Sean Verillo, Casey Ferrara, Dorian PustinaAbstractVoxel-based lesion-symptom mapping (VLSM) is an important method for basic and translational human neuroscience research. VLSM leverages modern neuroimaging analysis techniques to build on the classic approach of examining the relationship between location of brain damage and cognitive deficits. Testing an association between deficit severity and lesion status in each voxel involves very many individual tests and requires statistical correction...
Source: Neuropsychologia - July 10, 2018 Category: Neurology Source Type: research
The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings
This study investigated how sample size affects the reproducibility of findings from univariate voxel-based lesion-deficit analyses (e.g., voxel-based lesion-symptom mapping and voxel-based morphometry). Our effect of interest was the strength of the mapping between brain damage and speech articulation difficulties, as measured in terms of the proportion of variance explained. First, we identified a region of interest by searching on a voxel-by-voxel basis for brain areas where greater lesion load was associated with poorer speech articulation using a large sample of 360 right-handed English-speaking stroke survivors. We t...
Source: Neuropsychologia - July 10, 2018 Category: Neurology Source Type: research
What bilateral damage of the superior parietal lobes tells us about visual attention disorders in developmental dyslexia
Publication date: Available online 8 August 2018Source: NeuropsychologiaAuthor(s): S. Valdois, D. Lassus-Sangosse, M. Lallier, O. Moreaud, L. PisellaAbstractNeuroimaging studies have identified the superior parietal lobules bilaterally as the neural substrates of reduced visual attention (VA) span in developmental dyslexia. It remains however unclear whether the VA span deficit and the deficits in temporal and spatial attention shifting also reported in dyslexic children reflect a unitary spatio-temporal deficit of attention - probably linked to general posterior parietal dysfunction- or the dysfunction of distinct attenti...
Source: Neuropsychologia - August 9, 2018 Category: Neurology Source Type: research
Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys
Publication date: October 2018Source: Neuropsychologia, Volume 119Author(s): Matthew Ainsworth, Helen Browncross, Daniel J. Mitchell, Anna S. Mitchell, Richard E. Passingham, Mark J. Buckley, John Duncan, Andrew H. BellAbstractDamage following traumatic brain injury or stroke can often extend beyond the boundaries of the initial insult and can lead to maladaptive cortical reorganisation. On the other hand, beneficial cortical reorganisation leading to recovery of function can also occur. We used resting state FMRI to investigate how cortical networks in the macaque brain change across time in response to lesions to the pre...
Source: Neuropsychologia - September 13, 2018 Category: Neurology Source Type: research
Event-related potentials support a Dual process account of the Embedded Chinese Character Task
Publication date: Available online 29 October 2018Source: NeuropsychologiaAuthor(s): Yue Yin, Tingting Yu, Shu Wang, Shujin Zhou, Xiaochen Tang, Edward J.N. Stupple, Junlong LuoAbstractTests of the principles of dual process theory are typically conducted in the reasoning and judgement/decision-making literature. The present study explores dual process explanations with a new paradigm – the Embedded Chinese Character Task (ECCT). The beauty of this task is that it allows the contrast of automatic and deliberate processes without the potential for conflict. We used event-related potentials (ERPs) and behavioral measures t...
Source: Neuropsychologia - October 30, 2018 Category: Neurology Source Type: research
The involvement of left inferior frontal and middle temporal cortices in word production unveiled by greater facilitation effects following brain damage
Publication date: Available online 1 November 2018Source: NeuropsychologiaAuthor(s): Grégoire Python, Bertrand Glize, Marina LaganaroAbstractIn stroke-induced aphasia, left hemispheric lesions generally disturb the word production network. The left inferior frontal gyrus (LIFG) and the left middle temporal gyrus (LMTG) are involved in word production, but their respective contribution remains ambiguous. Previous investigations have largely focused on semantic interference to gather information about word production. Here we assessed the sensitivity of twenty-five aphasic speakers with either LIFG or LMTG lesions and match...
Source: Neuropsychologia - November 2, 2018 Category: Neurology Source Type: research
Neural correlates of improvements in personality and behavior following a neurological event
Publication date: Available online 21 November 2017Source: NeuropsychologiaAuthor(s): Marcie L. King, Kenneth Manzel, Joel Bruss, Daniel TranelAbstractResearch on changes in personality and behavior following brain damage has focused largely on negative outcomes, such as increased irritability, moodiness, and social inappropriateness. However, clinical observations suggest that some patients may actually show positive personality and behavioral changes following a neurological event. In the current work, we investigated neuroanatomical correlates of positive personality and behavioral changes following a discrete neurologi...
Source: Neuropsychologia - November 6, 2018 Category: Neurology Source Type: research
