Log in to search using one of your social media accounts:

 

The anatomy of apathy: a neurocognitive framework for amotivated behavior

Publication date: Available online 8 July 2017 Source:Neuropsychologia Author(s): C. Le Heron, M.A.J. Apps., M. Husain Apathy is a debilitating syndrome associated with many neurological disorders, including several common neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, and focal lesion syndromes such as stroke. Here, we review neuroimaging studies to identify anatomical correlates of apathy, across brain disorders. Our analysis reveals that apathy is strongly associated with disruption particularly of dorsal anterior cingulate cortex (dACC), ventral striatum (VS) and connected brain regions. Remarkably, these changes are consistent across clinical disorders and imaging modalities. Review of the neuroimaging findings allows us to develop a neurocognitive framework to consider potential mechanisms underlying apathy. According to this perspective, an interconnected group of brain regions – with dACC and VS at its core – plays a crucial role in normal motivated behaviour. Specifically we argue that motivated behaviour requires a willingness to work, to keep working, and to learn what is worth working for. We propose that deficits in any one or more of these processes can lead to the clinical syndrome of apathy, and outline specific approaches to test this hypothesis. A richer neurobiological understanding of the mechanisms underlying apathy should ultimately facilitate development of effective therapies for this disabling condition.
Source: Neuropsychologia - Category: Neurology Source Type: research

Related Links:

(University of California - Los Angeles) In research that potentially could delay the onset of Parkinson's disease, Alzheimer's disease, cancer, stroke, cardiovascular disease, and other diseases of aging, UCLA biologists have produced a genetic one-two punch that significantly slowed aging and improved health in the middle-aged fruit flies they studied.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
In conclusion, KPE delays intrinsic skin aging process by inhibiting cellular senescence and mitochondrial dysfunction. KPE does not only attenuate cellular senescence through inhibition of the p53/p21, p16/pRb, and PI3K/AKT signaling pathways but also improve mitochondrial biogenesis through PGC-1α stimulation. Consequently, KPE prevents wrinkle formation, skin atrophy, and loss of elasticity by increasing collagen and elastic fibers in hairless mice. The Society for the Rescue of our Elders https://www.fightaging.org/archives/2017/08/the-society-for-the-rescue-of-our-elders/ The Society for the...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study is fully enrolled. Future studies that will test NAD+ infusions for Parkinson's, Alzheimer's, and stroke patients, are being planned. Let us know if you'd like to participate. The rapamycin study site has been moved to Southern California. Funding has been secured to cover 100% of this study's cost. The primary cost of this and some other studies are the extensive clinical and biomarker measures that must be done to assess if biological age reversal is occurring. Enrollment for this study is currently open. The GDF11 trial is planned to initiate in Nassau, Bahamas around October of this year and will req...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Publication date: 2017 Source:International Review of Neurobiology, Volume 135 Author(s): Yao Yao, Ting Chen, Jing Huang, Hong Zhang, Mei Tian Chinese herbal medicine has been used to treat a wide variety of neurological disorders including stroke, Alzheimer's disease, and Parkinson's disease. However, its mechanism behind the effectiveness remains unclear. Recently, molecular imaging technology has been applied for this purpose, since it can assess the cellular or molecular function in a living subject by using specific imaging probes and/or radioactive tracers, which enable efficient analysis and monitoring the therapeu...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Abstract Neurological diseases have always been one of the leading cause of mobility and mortality world-widely. However, it is still lack of efficient agents. Agmatine, an endogenous polyamine, exerts its diverse biological characteristics and therapeutic potential in varied aspects. Moreover, there has been numerous studies demonstrated the neuroprotective effect of agmatine in varied types of neurological diseases, including acute attack (stroke and trauma brain injury) and chronic neurodegenerative diseases (Parkinson's disease, Alzheimer's disease). The potential mechanism of agmatine -induced neuroprote...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsAdministration of SSRIs may improve gross motor function, reduce disability and enhance QOL for patients recovering from stroke.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research
Docosahexaenoic acid, enriched in the brain and retina, generates docosanoids in response to disruptions of cellular homeostasis. Docosanoids include neuroprotectin D1 (NPD1), which is decreased in the CA1 hippocampal area of patients with early-stage Alzheimer's disease (AD). We summarize here how NPD1 elicits neuroprotection by up-regulating c-REL, a nuclear factor (NF)-κB subtype that, in turn, enhances expression of BIRC3 (baculoviral inhibitor of apoptosis repeat-containing protein 3) in the retina and in experimental stroke, leading to neuroprotection. Elucidating the mechanisms of action of docosanoids will co...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Minireviews Source Type: research
In this study, we determine whether intranasally (IN) administered DFO is beneficial in the intracerebroventricular streptozotocin (ICV STZ) rat model of sporadic Alzheimer's disease, which is different from previous models in that it exhibits dysregulation of insulin metabolism as well as oxidative stress and inflammation.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
(Louisiana State University Health Sciences Center) Understanding how dietary essential fatty acids work may lead to effective treatments for diseases and conditions such as stroke, Alzheimer's disease, age-related macular degeneration, Parkinson's disease and other retinal and neurodegenerative diseases. The key is to be able to intervene during the early stages of the disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
More News: Alzheimer's | Anatomy | Brain | Learning | Neurology | Parkinson's Disease | Stroke | Study | Universities & Medical Training