Filtered By:
Source: Metabolic Brain Disease
This page shows you your search results in order of relevance. This is page number 9.
Order by Relevance | Date
Total 151 results found since Jan 2013.
Panax notoginseng saponins administration modulates pro- /anti-inflammatory factor expression and improves neurologic outcome following permanent MCAO in rats
AbstractIschemic stroke, particularly permanent occlusion, accounts for the overwhelming majority of all strokes. In addition to the occlusion of arteries, the inflammatory response plays a pivotal role in the severity of the cerebral injury and its clinical prognosis. Here,panax notoginseng saponins (PNS) extracted from a traditional Chinese herbal medicine was administered following permanent middle cerebral artery occlusion (MCAO) in rats to explore the neuroprotective mechanisms against ischemic injury. The results showed that MCAO surgery was successful in producing an infarct and that PNS and nimodipine could amelior...
Source: Metabolic Brain Disease - September 1, 2016 Category: Neurology Source Type: research
DR α1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury
AbstractTraumatic brain injury (TBI) results in severe neurological impairments without effective treatments. Inflammation appears to be an important contributor to key pathogenic events such as secondary brain injury following TBI and therefore serves as a promising target for novel therapies. We have recently demonstrated the ability of a molecular construct comprised of the human leukocyte antigen (HLA)-DR α1 domain linked covalently to mouse (m)MOG-35-55 peptide (DRα1-MOG-35-55 construct) to reduce CNS inflammation and tissue injury in animal models of multiple sclerosis and ischemic stroke. The aim of the current st...
Source: Metabolic Brain Disease - September 12, 2017 Category: Neurology Source Type: research
Plasma microparticles in Alzheimer ’s disease: The role of vascular dysfunction
We examined the plasma changes of endothelial MPs (EMPs) and platelet MPs (PMPs) in AD patients with vascular risk factors. The plasma Annexin V+ CD 41a− CD144+ EMPs and Annexin V+ CD41a+ CD144− PMPs of 37 patients with AD, with or without vascular risk factors (hypertension, diabetes, dyslipidemia, stroke, coronary artery disease, and smoking), and 10 age-matched controls were quantified by flow cytometry. Pearson correlation analysis used to evaluate the linear relationship between variables. Significantly higher plasma levels of EMPs were observed in AD patients with vascular risk factors as compared to the patients...
Source: Metabolic Brain Disease - December 5, 2017 Category: Neurology Source Type: research
The macroscopic and microscopic effect of low-frequency whole-body vibration after cerebral ischemia in rats
AbstractWhole body vibration (WBV) has been applied in stroke patients with uncertain effects on motor and sensory dysfunction, and its effects on neurogenesis have not been studied yet. Here, we intended to explore the effects of daily WBV on neurological behavior, brain structure, and neurogenesis after cerebral ischemia in rats for 4 weeks. Results showed that improvements in weight or comprehensive neurological deficits were not significantly different under WBV or control treatment, and the degrees of brain damage and the numbers of necrotic neurons in the ischemic cortex were similar in two groups. However, WBV mar...
Source: Metabolic Brain Disease - January 15, 2018 Category: Neurology Source Type: research
Acquired hepatocerebral degeneration (AHD): a peculiar neurological impairment in advanced chronic liver disease
AbstractWe discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyramidal signs, arisen in a period of few days. Brain Magnetic Resonance Imaging (MRI) showed, in T1-weighted images, diffuse bilateral hyper intensities in basal ganglia and biemispheric brain and cerebellar cortices, resembling paramagnetic deposits. No other neurological impairments, like stroke, infe...
Source: Metabolic Brain Disease - January 15, 2018 Category: Neurology Source Type: research
Expression and regulation of miR-449a and AREG in cerebral ischemic injury
AbstractRodent focal ischemia models are widely used to mimic and examine human strokes. To the best of our knowledge, no investigation has systematically examined the expression changes of microRNA (miR)-449a and Amphiregulin (AREG) as well as their biological relationship during middle cerebral artery occlusion (MCAO) and oxygen and glucose deprivation/reperfusion (OGD/R). The present study examined the histological and behavioral outcomes of MCAO and the function of miR-449a and AREG in cerebral ischemic injury. Rats were subjected to 2 h MCAO, which was followed by reperfusion. miR-449a and AREG were examined in the ...
Source: Metabolic Brain Disease - February 18, 2019 Category: Neurology Source Type: research
Combination therapy of the granulocyte colony stimulating factor and intravenous lipid emulsion protect the hippocampus after global ischemia in rat: focusing on CA1 region
This study investigated the combined therapy of the Granulocyte colony stimulating factor (G-CSF) and the Intravenous lipid emulsion (ILE). These neuroprotective agents play a role in the regeneration of neurons. They improve the learning ability and memory in rats induced global ischemia. We divided 35 rats into five groups. The groups were sham group, ischemia group, G-CSF group, ILE group, and G-CSF plus ILE group. Ischemia was induced by occlusion of the bilateral common carotid about 10 min. The drugs applied on days 1, 3 and 7. The treated groups received subcutaneous injection of 20 μg/kg G-CSF and intravenous ...
Source: Metabolic Brain Disease - May 25, 2020 Category: Neurology Source Type: research
Neuroprotective effect of green and roasted coffee bean extracts on cerebral ischemia-induced injury in rats
In conclusion, GCBE and RCBE represent a potential clinical strategy for pre-ischemic conditioning.
Source: Metabolic Brain Disease - July 2, 2021 Category: Neurology Source Type: research
Neonatal seizures as onset of Inborn Errors of Metabolism (IEMs): from diagnosis to treatment. A systematic review
AbstractNeonatal seizures (NS) occur in the first 28 days of life; they represent an important emergency that requires a rapid diagnostic work-up to start a prompt therapy. The most common causes of NS include: intraventricular haemorrhage, hypoxic-ischemic encephalopathy, hypoglycemia, electrolyte imbalance, neonatal stroke or central nervous syste m infection. Nevertheless, an Inborn Error of Metabolism (IEM) should be suspected in case of NS especially if these are resistant to common antiseizure drugs (ASDs) and with metabolic decompensation. Nowadays, Expanded Newborn Screening (ENS) has changed the natural history ...
Source: Metabolic Brain Disease - August 17, 2021 Category: Neurology Source Type: research
Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition
AbstractIschemic stroke (IS) has become a cerebrovascular disease which seriously threatens the elderly people. It has been reported that circRNAs participate in multiple diseases, including IS. However, the role of circHECTD1 in IS remains largely unknown. To mimic IS in vitro, human cerebral microvascular endothelial cells (HCMECs) were treated with oxygen glucose deprivation/reperfusion (OGD/R). Meanwhile, MCAO mouse model was established to detect the expression of circHECTD1 in IS. qRT-PCR and western blot were used to test gene and protein expressions, respectively. CCK-8 assay was used to investigate the cell viabil...
Source: Metabolic Brain Disease - January 20, 2022 Category: Neurology Source Type: research
LncRNA CEBPA-AS1 knockdown prevents neuronal apoptosis against oxygen glucose deprivation/reoxygenation by regulating the miR-455/GPER1 axis
AbstractIschemic stroke (IS) is a common nervous system disease, which is a major cause of disability and death in the world. In present study, we demonstrated a regulatory mechanism of CCAAT/enhancer binding protein-alpha antisense 1 (CEBPA-AS1) in oxygen glucose deprivation/reoxygenation (OGD/R)-induced SH-SY5Y cells, with a focus on neuronal apoptosis. CEBPA-AS1, miR-455, and GPER1 expressions were evaluated by using qRT-PCR and Western blotting. The binding relationship among CEBPA-AS1, miR-455, and GPER1 was determined by a dual luciferase reporter assay. Neuronal viability and apoptosis were examined using MTT and fl...
Source: Metabolic Brain Disease - February 9, 2022 Category: Neurology Source Type: research
NGF/TrkA promotes the vitality, migration and adhesion of bone marrow stromal cells in hypoxia by regulating the Nrf2 pathway
ConclusionsNGF/TrkA promoted the viability, migration and adhesion of BMSCs in IS via activating Nrf2 pathway.
Source: Metabolic Brain Disease - May 17, 2022 Category: Neurology Source Type: research
