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Total 410 results found since Jan 2013.

Stroke Induces a BDNF-Dependent Improvement in Cognitive Flexibility in Aged Mice.
Abstract Stroke remains a leading cause of disability worldwide. Recently, we have established an animal model of stroke that results in delayed impairment in spatial memory, allowing us to better investigate cognitive deficits. Young and aged brains show different recovery profiles after stroke; therefore, we assessed aged-related differences in poststroke cognition. As neurotrophic support diminishes with age, we also investigated the involvement of brain-derived neurotrophic factor (BDNF) in these differences. Young (3-6 months old) and aged (16-21 months old) mice were trained in operant touchscreen chambers t...
Source: Neural Plasticity - June 15, 2019 Category: Neurology Authors: Houlton J, Zhou LYY, Barwick D, Gowing EK, Clarkson AN Tags: Neural Plast Source Type: research

Structural Covariance of the Ipsilesional Primary Motor Cortex in Subcortical Stroke Patients with Motor Deficits
This study is aimed at investigating the structural covariance pattern of the ipsilesional M1 in chronic subcortical stroke patients with motor deficits. High-resolution T1-weighted brain images were acquired from 58 chronic subcortical stroke patients with motor deficits (29 with left-sided lesions and 29 with right-sided lesions) and 50 healthy controls. Structural covariance patterns were identified by a seed-based structural covariance method based on gray matter (GM) volume. Group comparisons between stroke patients (left-sided or right-sided groups) and healthy controls were determined by a permutation test. The asso...
Source: Neural Plasticity - March 21, 2022 Category: Neurology Authors: Xinyuan Chen Mengcheng Li Naping Chen Huimin Lai Ziqiang Huang Yuqing Tu Qunlin Chen Jianping Hu Source Type: research

sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke
In this study, we aimed to explore the relationship between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and the prediction of the functional outcome in patients with recurrent and first-ever stroke. A total of 266 patients with recurrent and first-ever stroke, who underwent follow-up for 3 months, were included in this study. Plasma samples were collected within 24 h after onset. The results showed that biomarkers for the prognosis of patients with recurrent stroke were different from that of those with first-ever stroke. sLOX-1 levels were correlated with modified Rankin Scale scores of...
Source: Neural Plasticity - September 9, 2021 Category: Neurology Authors: Yangmin Zheng Yuyou Huang Lingzhi Li Pingping Wang Rongliang Wang Zhen Tao Junfen Fan Ziping Han Fangfang Li Haiping Zhao Fangfang Zhao Feng Yan Yumei Liu Yumin Luo Source Type: research

Nicotinamide Administration Improves Remyelination after Stroke.
CONCLUSIONS: Nicotinamide administration improves remyelination after stroke via the NAD(+)/BDNF/TrkB pathway. PMID: 28656112 [PubMed - in process]
Source: Neural Plasticity - June 30, 2017 Category: Neurology Authors: Wang C, Zhang Y, Ding J, Zhao Z, Qian C, Luan Y, Teng GJ Tags: Neural Plast Source Type: research

Dynamic Network Analysis Reveals Altered Temporal Variability in Brain Regions after Stroke: A Longitudinal Resting-State fMRI Study.
Abstract Recent fMRI studies have demonstrated that resting-state functional connectivity (FC) is of nonstationarity. Temporal variability of FC reflects the dynamic nature of brain activity. Exploring temporal variability of FC offers a new approach to investigate reorganization and integration of brain networks after stroke. Here, we examined longitudinal alterations of FC temporal variability in brain networks after stroke. Nineteen stroke patients underwent resting fMRI scans across the acute stage (within-one-week after stroke), subacute stage (within-two-weeks after stroke), and early chronic stage (3-4 mont...
Source: Neural Plasticity - June 6, 2018 Category: Neurology Authors: Hu J, Du J, Xu Q, Yang F, Zeng F, Weng Y, Dai XJ, Qi R, Liu X, Lu G, Zhang Z Tags: Neural Plast Source Type: research

Longitudinal Analysis of Stroke Patients' Brain Rhythms during an Intervention with a Brain-Computer Interface.
Abstract Stroke is a leading cause of motor disability worldwide. Upper limb rehabilitation is particularly challenging since approximately 35% of patients recover significant hand function after 6 months of the stroke's onset. Therefore, new therapies, especially those based on brain-computer interfaces (BCI) and robotic assistive devices, are currently under research. Electroencephalography (EEG) acquired brain rhythms in alpha and beta bands, during motor tasks, such as motor imagery/intention (MI), could provide insight of motor-related neural plasticity occurring during a BCI intervention. Hence, a longitudin...
Source: Neural Plasticity - May 22, 2019 Category: Neurology Authors: Carino-Escobar RI, Carrillo-Mora P, Valdés-Cristerna R, Rodriguez-Barragan MA, Hernandez-Arenas C, Quinzaños-Fresnedo J, Galicia-Alvarado MA, Cantillo-Negrete J Tags: Neural Plast Source Type: research

Finding the Intersection of Neuroplasticity, Stroke Recovery, and Learning: Scope and Contributions to Stroke Rehabilitation.
Conclusions: Our novel approach developed for this review allowed the identification of the common themes/topics that intersect the concepts of neuroplasticity, stroke recovery, and learning. These may be synthesised to advance a neuroscience-informed approach to stroke rehabilitation. We also identified gaps in available literature using this approach. These may help guide future targeted research. PMID: 31191637 [PubMed - in process]
Source: Neural Plasticity - June 15, 2019 Category: Neurology Authors: Carey L, Walsh A, Adikari A, Goodin P, Alahakoon D, De Silva D, Ong KL, Nilsson M, Boyd L Tags: Neural Plast Source Type: research

The Effect of Swallowing Action Observation Therapy on Resting fMRI in Stroke Patients with Dysphagia
CONCLUSION: Action observation therapy can affect the excitability of certain brain regions. The changes in brain function brought about by this treatment may help to further understand the potential mechanism of network remodeling of swallowing function.PMID:37124873 | PMC:PMC10147521 | DOI:10.1155/2023/2382980
Source: Neural Plasticity - May 1, 2023 Category: Neurology Authors: Ming Zeng Zhongli Wang Xuting Chen Meifang Shi Meihong Zhu Jingmei Ma Yunhai Yao Yao Cui Hua Wu Jie Shen Lingfu Xie Jianming Fu Xudong Gu Source Type: research