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Source: Neural Plasticity

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Total 410 results found since Jan 2013.

Assessed and Emerging Biomarkers in Stroke and Training-Mediated Stroke Recovery: State of the Art.
Abstract Since the increasing update of the biomolecular scientific literature, biomarkers in stroke have reached an outstanding and remarkable revision in the very recent years. Besides the diagnostic and prognostic role of some inflammatory markers, many further molecules and biological factors have been added to the list, including tissue derived cytokines, growth factor-like molecules, hormones, and microRNAs. The literatures on brain derived growth factor and other neuroimmune mediators, bone-skeletal muscle biomarkers, cellular and immunity biomarkers, and the role of microRNAs in stroke recovery were review...
Source: Neural Plasticity - April 6, 2017 Category: Neurology Authors: Gandolfi M, Smania N, Vella A, Picelli A, Chirumbolo S Tags: Neural Plast Source Type: research

The Activation of the Mirror Neuron System during Action Observation and Action Execution with Mirror Visual Feedback in Stroke: A Systematic Review.
Conclusions: MVF may contribute to stroke recovery by revising the interhemispheric imbalance caused by stroke due to the activation of the MNS. AO may also promote motor relearning in stroke individuals by activating the MNS and motor cortex. PMID: 29853839 [PubMed - in process]
Source: Neural Plasticity - June 6, 2018 Category: Neurology Authors: Zhang JJQ, Fong KNK, Welage N, Liu KPY Tags: Neural Plast Source Type: research

Modulation of Motor Cortical Activities by Action Observation and Execution in Patients with Stroke: An MEG Study.
This study was aimed at investigating the effects of action observation and two types of AOE on motor cortical activations after stroke using magnetoencephalography. Twenty patients with stroke and 20 healthy controls were recruited for the collection of data on the beta oscillatory activity in the primary motor cortex (M1). All participants performed the conditions of resting, observation only, and video observation combined with execution (video AOE). Stroke patients performed one additional condition of affected hand observation combined with execution (affected hand AOE). The relative change index of beta oscillations ...
Source: Neural Plasticity - December 1, 2019 Category: Neurology Authors: Zhu JD, Cheng CH, Tseng YJ, Chou CC, Chen CC, Hsieh YW, Liao YH Tags: Neural Plast Source Type: research

Different Therapeutic Effects of Transcranial Direct Current Stimulation on Upper and Lower Limb Recovery of Stroke Patients with Motor Dysfunction: A Meta-Analysis.
Conclusion: tDCS is effective for the recovery of stroke patients with motor dysfunction. In addition, upper limb and lower limb functions obtain distinct effects from different therapeutic parameters of tDCS at different stages, respectively. PMID: 31827495 [PubMed - in process]
Source: Neural Plasticity - December 14, 2019 Category: Neurology Authors: Bai X, Guo Z, He L, Ren L, McClure MA, Mu Q Tags: Neural Plast Source Type: research

Effect and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Recovery of Upper Limb Motor Function in Subacute Ischemic Stroke Patients: A Randomized Pilot Study.
Conclusions: This study revealed that taVNS appeared to be beneficial to the recovery of upper limb motor function in subacute ischemia stroke patients without obvious adverse effects. Trial registration. This trial is registered with ChiCTR1800019635 on 20 November 2018 (http://www.chictr.org.cn/showproj.aspx?proj=32961). PMID: 32802039 [PubMed - in process]
Source: Neural Plasticity - August 19, 2020 Category: Neurology Authors: Wu D, Ma J, Zhang L, Wang S, Tan B, Jia G Tags: Neural Plast Source Type: research

Altered functional connectivity of cognitive-related cerebellar subregions in well-recovered stroke patients.
Abstract The cerebellum contains several cognitive-related subregions that are involved in different functional networks. The cerebellar crus II is correlated with the frontoparietal network (FPN), whereas the cerebellar IX is associated with the default-mode network (DMN). These two networks are anticorrelated and cooperatively implicated in cognitive control, which may facilitate the motor recovery in stroke patients. In the present study, we aimed to investigate the resting-state functional connectivity (rsFC) changes in 25 subcortical ischemic stroke patients with well-recovered global motor function. Consiste...
Source: Neural Plasticity - July 19, 2013 Category: Neurology Authors: Li W, Han T, Qin W, Zhang J, Liu H, Li Y, Meng L, Ji X, Yu C Tags: Neural Plast Source Type: research

Physical Exercise as a Diagnostic, Rehabilitation, and Preventive Tool: Influence on Neuroplasticity and Motor Recovery after Stroke.
Abstract Stroke remains a leading cause of adult motor disabilities in the world and accounts for the greatest number of hospitalizations for neurological disease. Stroke treatments/therapies need to promote neuroplasticity to improve motor function. Physical exercise is considered as a major candidate for ultimately promoting neural plasticity and could be used for different purposes in human and animal experiments. First, acute exercise could be used as a diagnostic tool to understand new neural mechanisms underlying stroke physiopathology. Indeed, better knowledge of stroke mechanisms that affect movements is c...
Source: Neural Plasticity - December 21, 2015 Category: Neurology Authors: Pin-Barre C, Laurin J Tags: Neural Plast Source Type: research

Effects of a Single Session of High Intensity Interval Treadmill Training on Corticomotor Excitability following Stroke: Implications for Therapy.
Conclusions. HIITT suppresses corticomotor excitability in some people with chronic stroke. When HIITT is preceded by tDCS in combination with a skill acquisition task, the asymmetry of between-hemisphere corticomotor excitability is reduced. Significance. This study provides preliminary data indicating that the cardiovascular benefits of HIITT may be achieved without suppressing motor excitability in some stroke survivors. PMID: 27738524 [PubMed - in process]
Source: Neural Plasticity - October 17, 2016 Category: Neurology Authors: Madhavan S, Stinear JW, Kanekar N Tags: Neural Plast Source Type: research

Recovery of the 20  Hz Rebound to Tactile and Proprioceptive Stimulation after Stroke.
Recovery of the 20 Hz Rebound to Tactile and Proprioceptive Stimulation after Stroke. Neural Plast. 2018;2018:7395798 Authors: Parkkonen E, Laaksonen K, Parkkonen L, Forss N Abstract Sensorimotor integration is closely linked to changes in motor-cortical excitability, observable in the modulation of the 20 Hz rhythm. After somatosensory stimulation, the rhythm transiently increases as a rebound that reflects motor-cortex inhibition. Stroke-induced alterations in afferent input likely affect motor-cortex excitability and motor recovery. To study the role of somatosensory afferents in motor-cortex e...
Source: Neural Plasticity - April 24, 2018 Category: Neurology Authors: Parkkonen E, Laaksonen K, Parkkonen L, Forss N Tags: Neural Plast Source Type: research

Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity.
We examined the performance of candidate structural, functional, and angiogenesis-related MRI biomarkers before and after a 3-week course of standardized robotic therapy in 18 patients with chronic stroke and hypothesized that results vary significantly according to stroke severity. Patients were 4.1 ± 1 months poststroke, with baseline arm Fugl-Meyer scores of 20-60. When all patients were examined together, no imaging measure changed over time in a manner that correlated with treatment-induced motor gains. However, when also considering the interaction with baseline motor status, treatment-induced motor gains were s...
Source: Neural Plasticity - May 4, 2018 Category: Neurology Authors: Quinlan EB, Dodakian L, See J, McKenzie A, Stewart JC, Cramer SC Tags: Neural Plast Source Type: research

State-of-the-Art Techniques to Causally Link Neural Plasticity to Functional Recovery in Experimental Stroke Research.
Abstract Current experimental stroke research faces the same challenge as neuroscience: to transform correlative findings in causative ones. Research of recent years has shown the tremendous potential of the central nervous system to react to noxious stimuli such as a stroke: Increased plastic changes leading to reorganization in form of neuronal rewiring, neurogenesis, and synaptogenesis, accompanied by transcriptional and translational turnover in the affected cells, have been described both clinically and in experimental stroke research. However, only minor attempts have been made to connect distinct plastic re...
Source: Neural Plasticity - July 7, 2018 Category: Neurology Authors: Wahl AS Tags: Neural Plast Source Type: research

Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke.
Abstract Motor capability recovery after ischemic stroke involves dynamic remodeling processes of neural connectomes in the nervous system. Various neuromodulatory strategies combining direct stimulating interventions with behavioral trainings for motor recovery after ischemic stroke have been developed. However, the effectiveness of these interventions varies widely due to unspecific activation or inhibition of undefined neuronal subtypes. Optogenetics is a functional and structural connection-based approach that can selectively activate or inhibit specific subtype neurons with a higher precision, and it has been...
Source: Neural Plasticity - April 24, 2019 Category: Neurology Authors: Lu C, Wu X, Ma H, Wang Q, Wang Y, Luo Y, Li C, Xu H Tags: Neural Plast Source Type: research

Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores.
Conclusions: We provide evidence that fALFF is sensitive to changes in poststroke depressive symptom severity and implicates frontostriatal and cerebellar regions, consistent with previous studies. The use of multiband analysis could be an effective method to examine neural correlates of depression after stroke. The START-PrePARE trial is registered with the Australian New Zealand Clinical Trial Registry, number ACTRN12610000987066. PMID: 31467520 [PubMed - in process]
Source: Neural Plasticity - August 31, 2019 Category: Neurology Authors: Goodin P, Lamp G, Vidyasagar R, Connelly A, Rose S, Campbell BCV, Tse T, Ma H, Howells D, Hankey GJ, Davis S, Donnan G, Carey LM Tags: Neural Plast Source Type: research

Opportunities and Limitations of Vascular Risk Factor Models in Studying Plasticity-Promoting and Restorative Ischemic Stroke Therapies.
Abstract Major efforts are currently made promoting neuronal plasticity and brain remodeling in the postacute stroke phase. Experimental studies evaluating new stroke therapies are mostly performed in rodents, which compared to humans exhibit a short lifespan. These studies widely employ young, otherwise healthy, rodents that lack the vascular risk factors and comorbidities of stroke patients. These risk factors compromise postischemic neurological recovery and brain plasticity and in several contexts reduce the brain responsiveness to recovery-inducing plasticity-promoting treatments. By examining risk factor mod...
Source: Neural Plasticity - December 14, 2019 Category: Neurology Authors: Hermann DM, Doeppner TR, Popa-Wagner A Tags: Neural Plast Source Type: research

Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities.
Abstract With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute phase upon stroke onset, which not only is a difficult way to ameliorate stroke symptoms but also presents a challenge for the patients to receive effective treatment in time. The brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult brain, which possesses a remarkable capability to repair brain damage. Recent promising p...
Source: Neural Plasticity - May 14, 2020 Category: Neurology Authors: Liu W, Wang X, O'Connor M, Wang G, Han F Tags: Neural Plast Source Type: research