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Structure-Based Virtual Screening to Identify Negative Allosteric Modulators of NMDA
CONCLUSION: The product of the study are compounds which have been validated through pharmacophore and score-based screening and MD simulation techniques to be allosterically inhibiting NMDA receptors and with favorable pharmacokinetic profile are likely to be therapeutic agents ready for in-vitro and in-vivo testing.PMID:35249502 | DOI:10.2174/1573406418666220304224150
Source: Medicinal Chemistry - March 7, 2022 Category: Chemistry Authors: Zaid Anis Sherwani Ruqaiya Khalil Mohammad Nur-E-Alam Sarfaraz Ahmed Zaheer Ul-Haq Source Type: research

Molecules, Vol. 27, Pages 7174: Repurposing SGLT2 Inhibitors for Neurological Disorders: A Focus on the Autism Spectrum Disorder
l Akour Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a substantially increasing incidence rate. It is characterized by repetitive behavior, learning difficulties, deficits in social communication, and interactions. Numerous medications, dietary supplements, and behavioral treatments have been recommended for the management of this condition, however, there is no cure yet. Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory effects, such as downregulating the express...
Source: Molecules - October 23, 2022 Category: Chemistry Authors: Mohammed Moutaz Nakhal Salahdein Aburuz Bassem Sadek Amal Akour Tags: Review Source Type: research