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Total 10 results found since Jan 2013.

Integration of ultra-high-pressure liquid chromatography-tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke.
We report for the first time the integration of ultra-high-pressure liquid chromatography-tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke. In particular, we develop an optimal model to discriminate ischemic stroke patients from healthy persons with 100% sensitivity and 93.18% specificity. This research may facilitate understanding the roles of fatty acid metabolites in stroke occurrence, holding great potential in clinical stroke diagnosis. PMID: 32409805 [PubMed - as supplied by publisher]
Source: Chemical Communications - May 14, 2020 Category: Chemistry Authors: Zhang L, Ma F, Qi A, Liu L, Zhang J, Xu S, Zhong Q, Chen Y, Zhang CY, Cai C Tags: Chem Commun (Camb) Source Type: research

Integration of ultra-high-pressure liquid chromatography –tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC02329A, CommunicationLijian Zhang, Fei Ma, Ao Qi, Lulu Liu, Junjie Zhang, Simin Xu, Qisheng Zhong, Yusen Chen, Chun-yang Zhang, Chun Cai We demonstrated the integration of UHPLC –MS/MS with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - May 15, 2020 Category: Chemistry Authors: Lijian Zhang Source Type: research

The role of GFAP and vimentin in learning and memory.
Authors: Wilhelmsson U, Pozo-Rodrigalvarez A, Kalm M, Pablo Y, Widestrand Å, Pekna M, Pekny M Abstract Intermediate filaments (also termed nanofilaments) are involved in many cellular functions and play important roles in cellular responses to stress. The upregulation of glial fibrillary acidic protein (GFAP) and vimentin (Vim), intermediate filament proteins of astrocytes, is the hallmark of astrocyte activation and reactive gliosis in response to injury, ischemia or neurodegeneration. Reactive gliosis is essential for the protective role of astrocytes at acute stages of neurotrauma or ischemic stroke. However, G...
Source: Biological Chemistry - May 9, 2019 Category: Chemistry Tags: Biol Chem Source Type: research

Structure-Based Virtual Screening to Identify Negative Allosteric Modulators of NMDA
CONCLUSION: The product of the study are compounds which have been validated through pharmacophore and score-based screening and MD simulation techniques to be allosterically inhibiting NMDA receptors and with favorable pharmacokinetic profile are likely to be therapeutic agents ready for in-vitro and in-vivo testing.PMID:35249502 | DOI:10.2174/1573406418666220304224150
Source: Medicinal Chemistry - March 7, 2022 Category: Chemistry Authors: Zaid Anis Sherwani Ruqaiya Khalil Mohammad Nur-E-Alam Sarfaraz Ahmed Zaheer Ul-Haq Source Type: research

Molecules, Vol. 27, Pages 7174: Repurposing SGLT2 Inhibitors for Neurological Disorders: A Focus on the Autism Spectrum Disorder
l Akour Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a substantially increasing incidence rate. It is characterized by repetitive behavior, learning difficulties, deficits in social communication, and interactions. Numerous medications, dietary supplements, and behavioral treatments have been recommended for the management of this condition, however, there is no cure yet. Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory effects, such as downregulating the express...
Source: Molecules - October 23, 2022 Category: Chemistry Authors: Mohammed Moutaz Nakhal Salahdein Aburuz Bassem Sadek Amal Akour Tags: Review Source Type: research

Molecules, Vol. 28, Pages 2598: Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia
This study explored the effects of Gas and HBA on cognitive dysfunction in VD and their possible molecular mechanisms. The VD model was established by bilateral common carotid artery ligation (2-vessel occlusion, 2-VO) combined with an intraperitoneal injection of sodium nitroprusside solution. One week after modeling, Gas (25 and 50 mg/kg, i.g.) and HBA (25 and 50 mg/kg, i.g.) were administered orally for four weeks, and the efficacy was evaluated. A Morris water maze test and passive avoidance test were used to observe their cognitive function, and H&amp;E staining and Nissl staining were used to observe the neur...
Source: Molecules - March 13, 2023 Category: Chemistry Authors: Sha Wu Rong Huang Ruiqin Zhang Chuang Xiao Lueli Wang Min Luo Na Song Jie Zhang Fang Yang Xuan Liu Weimin Yang Tags: Article Source Type: research