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Wake-up Stroke and Onset-to-door Duration Delays: Potential Future Indications for Reperfusion Therapy.
Conclusion: The one- third proportion of wake-up stroke in this cohort and low prevalence of relative contraindications suggest this is a promising group for emerging thrombolysis indications. With the majority of patients presenting after 8 hours, widening of the therapeutic window with new potential reperfusion treatments would not appreciably increase treatment utilisation. This study reaffirms the urgent need for public education to improve stroke awareness in Singapore. PMID: 24557460 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - January 1, 2014 Category: Journals (General) Authors: Tan MSh, Ang ES, Ho SS, Ng SC, Talabucon L, Woon FP, De Silva DA Tags: Ann Acad Med Singapore Source Type: research

Intravenous Recombinant Tissue Plasminogen Activator and Ischemic Stroke: Focused Update of 2010 Clinical Practice Advisory From the American Academy of Emergency Medicine
Stroke treatment is a continuum that begins with the rapid identification of symptoms and treatment with transition to successful rehabilitation. Therapies for acute ischemic stroke (AIS) may vary based on anatomic location, interval from symptom onset, and coexisting health conditions. Successful therapy requires a seamless systematic approach with coordination from prehospital environment through acute management at medical facilities to disposition and long-term care of the patient. The emergency physician must balance the benefits and risks of alteplase recombinant tissue plasminogen activator (rtPA) for AIS management.
Source: The Journal of Emergency Medicine - March 12, 2018 Category: Emergency Medicine Authors: William J. Meurer, Bradley Barth, Michael Abraham, Jerome Hoffman, Gary M. Vilke, Gerard DeMers Tags: AAEM Clinical Practice Source Type: research

Tenecteplase and alteplase for thrombolysis of acute ischemic stroke within 4.5 hours: An efficacy and safety study
Conclusions: This study showed a comparable efficacy and safety profile of alteplase and TNK in thrombolysis of AIS throughout the 4.5 hours window period. Moreover, the ease of administration and better pharmacodynamic properties favors tenecteplase.
Source: Annals of Indian Academy of Neurology - October 31, 2022 Category: Neurology Authors: Nikita Dhar Mritunjai Kumar Ashutosh Tiwari Ishita Desai Govind Madhaw Niraj Kumar Source Type: research

Biosimilar tenecteplase versus alteplase in acute ischemic stroke: A real world study
Conclusion: This present study observed no difference in the efficacy and safety between biosimilar TNK and rTPA. Our findings are in concordance with published trials showing equivalence between the two molecules.
Source: Annals of Indian Academy of Neurology - January 25, 2023 Category: Neurology Authors: Ayush Mohan Snigdha Komakula Suhas Murali Pooja Anand Dyuti Shah VY Vishnu Awadh Kishor Pandit Ayush Agarwal Deepti Vibha Mamta Bhushan Singh MV Padma Srivastava Rohit Bhatia Source Type: research

New Guidelines on tPA in Stroke: Putting Out Fires With Gasoline?
When a joint panel representing the American College of Emergency Physicians (ACEP) and the American Academy of Neurology (AAN) issued guidelines on the use of recombinant tissue-type plasminogen activator (rt-PA, alteplase, or tPA) in patients receiving a diagnosis of ischemic stroke, proponents of this treatment may have heaved a sigh of relief.
Source: Annals of Emergency Medicine - June 29, 2013 Category: Emergency Medicine Authors: William B. Millard Tags: News and Perspective Source Type: research

Is tenecteplase a viable alternative to alteplase in the treatment of acute ischemic stroke ?
Anand Girish VaishnavAnnals of Indian Academy of Neurology 2022 25(5):794-795
Source: Annals of Indian Academy of Neurology - October 31, 2022 Category: Neurology Authors: Anand Girish Vaishnav Source Type: research