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Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota
Conclusion Collectively, pharmacokinetic and pharmacodynamic association studies provide evidence that the gut microbiota plays a vital role in the fate of crocin and crocetin in the gastrointestinal tract. In addition, the cross-interaction between gut microbiota and crocin might mediate the activation of the cerebral-protective effect of orally administered crocin. Ethics Statement This study was carried out in accordance with the recommendations of ‘Institutional Animal Research Committee guidelines, Animal Ethics Committee of China Pharmaceutical University.’ The protocol was approved by the ‘An...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Increased ionized calcium-magnesium-ratio in elderly hypertensives - relationship to artheriosclerosis
CONCLUSIONS: As described earlier, a magnesium deficiency can be involved in the pathogenesis of hypertension and in elderly.The increased calcium-magnesium-ratio is also a pathogenetic factor for artheriosclerosis often found in elderly hypertensives with vascular damage, e.g. stroke, renal insufficiency or heart disease.PMID:36026911 | DOI:10.1097/01.hjh.0000836640.98666.86
Source: Atherosclerosis - August 26, 2022 Category: Cardiology Authors: Kisters Kisters Klaus Kisters Lukas Gremmler Bernhard Sprenger Jutta Gr öber Uwe Source Type: research

Increased ionized calcium-magnesium-ratio in elderly hypertensives - relationship to artheriosclerosis
CONCLUSIONS: As described earlier, a magnesium deficiency can be involved in the pathogenesis of hypertension and in elderly.The increased calcium-magnesium-ratio is also a pathogenetic factor for artheriosclerosis often found in elderly hypertensives with vascular damage, e.g. stroke, renal insufficiency or heart disease.PMID:36026911 | DOI:10.1097/01.hjh.0000836640.98666.86
Source: Atherosclerosis - August 26, 2022 Category: Cardiology Authors: Kisters Kisters Klaus Kisters Lukas Gremmler Bernhard Sprenger Jutta Gr öber Uwe Source Type: research