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Prospective study of IL-18 and risk of MI and stroke in men and women aged 60-79years: A nested case-control study.
CONCLUSIONS: Circulating IL-18 levels were strongly associated with a range of established and novel risk factors but were not independently associated with risk of MI or stroke in our study. PMID: 23207179 [PubMed - as supplied by publisher]
Source: Cytokine - November 30, 2012 Category: Molecular Biology Authors: Jefferis BJ, Whincup PH, Welsh P, Wannamethee SG, Rumley A, Ebrahim S, Lawlor DA, Lowe GD Tags: Cytokine Source Type: research

One-Year Risk of Stroke After Transient Ischemic Attack or Minor Stroke in Hunter New England, Australia (INSIST Study)
Conclusion: One-year risk of stroke in TIAMS participants was lower than reported in previous studies. Early implementation of antiplatelet/anticoagulant therapies may have contributed to the low stroke recurrence.
Source: Frontiers in Neurology - December 20, 2021 Category: Neurology Source Type: research

Myocardial infarction and stroke subsequent to urinary tract infection (MISSOURI): protocol for a self-controlled case series using linked electronic health records
Introduction There is increasing interest in the relationship between acute infections and acute cardiovascular events. Most previous research has focused on understanding whether the risk of acute cardiovascular events increases following a respiratory tract infection. The relationship between urinary tract infections (UTIs) and acute cardiovascular events is less well studied. Therefore, the aim of this study is to determine whether there is a causal relationship between UTI and acute myocardial infarction (MI) or stroke. Methods and analysis We will undertake a self-controlled case series study using linked anonymised ...
Source: BMJ Open - September 22, 2022 Category: General Medicine Authors: Reeve, N. F., Best, V., Gillespie, D., Hughes, K., Lugg-Widger, F. V., Cannings-John, R., Torabi, F., Wootton, M., Akbari, A., Ahmed, H. Tags: Open access, Infectious diseases Source Type: research

Rural versus metropolitan comparison of processes of care in the community-based management of TIA and minor stroke in Australia (an analysis from the INSIST study)
CONCLUSIONS: Although TIAMS prognosis in rural settings where solely GP care is common is very good, the processes of care in such areas are inferior to metropolitan. This suggests there is further scope to support rural GPs to optimise care of TIAMS patients.PMID:36382851 | DOI:10.1111/ajr.12950
Source: The Australian Journal of Rural Health - November 16, 2022 Category: Rural Health Authors: Shyam Gangadharan Shinya Tomari Christopher R Levi Natasha Weaver Elizabeth Holliday Beata Bajorek Daniel Lasserson Jose M Valderas Helen M Dewey Peter Alan Barber Neil J Spratt Dominique A Cadilhac Valery L Feigin Peter M Rothwell Hossein Zareie Carlos G Source Type: research

Prescribing of direct oral anticoagulants and warfarin to older people with atrial fibrillation in UK general practice: a cohort study
Anticoagulation for stroke prevention in atrial fibrillation (AF) has, historically, been under-used in older people. The aim of this study was to investigate prescribing of oral anticoagulants (OACs) for peop...
Source: BMC Medicine - August 31, 2021 Category: Internal Medicine Authors: Anneka Mitchell, Julia Snowball, Tomas J. Welsh, Margaret C. Watson and Anita McGrogan Tags: Research article Source Type: research

Unlucky numbers: Fighting murder convictions that rest on shoddy stats
LEIDEN, THE NETHERLANDS— When a Dutch nurse named Lucia de Berk stood trial for serial murder in 2003, statistician Richard Gill was aware of the case. But he saw no reason to stick his nose into it. De Berk was a pediatric nurse at Juliana Children’s Hospital in The Hague. In 2001, after a baby died while she was on duty, a colleague told superiors that De Berk had been present at a suspiciously high number of deaths and resuscitations. Hospital staff immediately informed the police. When investigators reexamined records from De Berk’s shifts, they found 10 suspicious incidents. Three other hospitals where D...
Source: Science of Aging Knowledge Environment - January 19, 2023 Category: Geriatrics Source Type: research