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Condition: Atrial Fibrillation
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Dabigatran for Japanese Patients with Atrial Fibrillation and Prior Stroke: A Subgroup Analysis of the J-Dabigatran Surveillance Program
Background: The study objective was to evaluate long-term safety and effectiveness of dabigatran 110 mg and 150 mg twice daily (bid) in patients with nonvalvular atrial fibrillation (NVAF) with a focus on secondary stroke prevention. Methods: In J-Dabigatran Surveillance, 6772 patients newly initiated on dabigatran to prevent ischemic stroke and systemic embolism were enrolled in Japan (1042 sites, December 2011 to November 2013). This subgroup analysis included patients with (1302) and without (5071) previous stroke/transient ischemic attack (TIA).
Source: Journal of Stroke and Cerebrovascular Diseases - February 25, 2020 Category: Neurology Authors: Masahiro Yasaka, Shinichiro Uchiyama, Hirotsugu Atarashi, Ken Okumura, Yukihiro Koretsune, Takeshi Yamashita, Atsushi Taniguchi, Taku Fukaya, Hiroshi Inoue, for the J-Dabigatran Surveillance Investigators Tags: Original article Source Type: research

Stroke-Related Visual Impairment; is There an Association with Atrial Fibrillation?
This study explores whether presence of visual impairment following stroke is associated with presence of atrial fibrillation (AF).
Source: Journal of Stroke and Cerebrovascular Diseases - August 23, 2020 Category: Neurology Authors: Fiona J Rowe, Lauren R Hepworth, Claire Howard, Claire Cullen, Benjamin Sturgess, Natalie Griffiths, Gregory Y H Lip Source Type: research

Effects of Sodium/Glucose Cotransporter Inhibitors on Atrial Fibrillation and Stroke: A Meta-Analysis
Globally, the number of people estimated to have diabetes mellitus (DM) in 2019 was 463 million, and the estimated number is expected to rise to 578 million people by 2030.1 DM is also associated with an increased risk of atrial fibrillation (AF), 2 and has shown to be an independent risk factor for stroke in patients with AF.3 A meta-analysis of 102 studies further showed that patients with diabetes have a higher risk of all subtypes of stroke (ischemic, hemorrhagic and unclassified stroke).4 This has generated great interest in anti-hyperglycemic agents and their ability to reduce the cardiovascular complications of diabetes.
Source: Journal of Stroke and Cerebrovascular Diseases - October 22, 2021 Category: Neurology Authors: How Ting Ong, Yao Hao Teo, Yao Neng Teo, Nicholas LX Syn, Caitlin Fern Wee, Shariel Leong, Alicia Swee Yan Yip, Ray Meng See, Adriel Zhi Hen Ting, Alys ZQ Chia, Alex Jia Yang Cheong, Benjamin Yong-Qiang Tan, Jamie Sin-Ying Ho, Leonard Leong-Litt Yeo, Aloy Source Type: research

Impact of Arrhythmia in Hospital Mortality in Acute Ischemic Stroke Patients: A Retrospective Cohort Study in Northern Mexico
Stroke remains one of the leading causes of death globally. 1 In Mexico, it represents the 6th cause of death2 and contributes with 688.19 DALYs per 100,000 people,3 constituting a major cause of burden of disease in the country. Heart rhythm dysfunctions following acute ischemic strokes (AIS) have been previously reported,4 –9 and it is expected that 25-30% of patients will be diagnosed with any type of arrhythmia after stroke.6,9 Kallmünze et al. reported the incidence of several post-stroke arrhythmias, such as atrial fibrillation (AF), focal atrial tachycardia, undetermined supraventricular tachycardia, ventricu la...
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2021 Category: Neurology Authors: J. De la Fuente-Mart ínez, A. Infante-Valenzuela, D. Martínez-Roque, M. Cruz-Moreno, F. Góngora-Rivera Source Type: research

Bridging thrombolysis in atrial fibrillation stroke is associated with increased hemorrhagic complications without improved outcomes
Conclusion In this large thrombectomy registry, AF patients exposed to IVT before MT had increased hemorrhagic complications without improved functional outcomes, in contrast with non-AF patients. Prospective trials are warranted to assess whether AF patients represent a subgroup of LVO patients who may benefit from a direct to thrombectomy approach at thrombectomy capable centers.
Source: Journal of NeuroInterventional Surgery - September 14, 2022 Category: Neurosurgery Authors: Akbik, F., Alawieh, A., Dimisko, L., Howard, B. M., Cawley, C. M., Tong, F. C., Nahab, F., Samuels, O. B., Maier, I., Feng, W., Goyal, N., Starke, R. M., Rai, A., Fargen, K. M., Psychogios, M. N., Jabbour, P., De Leacy, R., Keyrouz, S. G., Dumont, T. M., Tags: Ischemic stroke Source Type: research

Enlarged left atrium may be associated with laterality of anterior circulation cardioembolic stroke
In this study, we compared the hemispheric differences among patients with AF-stroke and identified factors associated with lesion laterality.
Source: Journal of Stroke and Cerebrovascular Diseases - January 21, 2023 Category: Neurology Authors: Sang Hee Ha, So Young Yang, Soo Jeong, Jae Young Park, Jun Young Chang, Dong-Wha Kang, Sun U. Kwon, Jong-Sung Kim, Bum Joon Kim Tags: Short Communication Source Type: research

Newly detected paroxysmal atrial fibrillation after tia and ischaemic stroke on cardiac monitoring: systematic review and meta-analysis in relation to duration of recording
Conclusion Cardiac monitoring after TIA or ischaemic stroke detects clinically important rates of pAF in studies of unselected populations, with high rates of subsequent anticoagulation. A monitoring period of 5–7 days appears to be adequate.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Yiin, G. S., Lovett, N. G., Rothwell, P. M. Tags: Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Rivaroxaban versus Warfarin in Japanese Patients with Nonvalvular Atrial Fibrillation for the Secondary Prevention of Stroke: A Subgroup Analysis of J-ROCKET AF
Conclusions: The safety and efficacy profile of rivaroxaban compared with warfarin was consistent among patients in the primary prevention group and those in the secondary prevention group.
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2013 Category: Neurology Authors: Norio Tanahashi, Masatsugu Hori, Masayasu Matsumoto, Shin-ichi Momomura, Shinichiro Uchiyama, Shinya Goto, Tohru Izumi, Yukihiro Koretsune, Mariko Kajikawa, Masaharu Kato, Hitoshi Ueda, Kazuya Iwamoto, Masahiro Tajiri, J-ROCKET AF Study Investigators Tags: Original Articles Source Type: research

Paroxysmal Atrial Fibrillation in Cryptogenic Stroke: A Case–Control Study
Conclusions: Very short episodes of PAF are common in patients with CS and with SKC, but their pathogenic significance is unclear. Predominance of PAF in younger patients with CS and embolic infarct pattern suggests a causative role in these cases. More research is needed before prolonged cardiac rhythm monitoring can be recommended to guide anticoagulation in CS patients.
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2013 Category: Neurology Authors: Alejandro A. Rabinstein, Jennifer E. Fugate, Jay Mandrekar, Joseph D. Burns, Raymond C.S. Seet, Stefan A. Dupont, Timothy J. Kauffman, Samuel J. Asirvatham, Paul A. Friedman Tags: Original Articles Source Type: research

Predictors of In-hospital Mortality and the Risk of Symptomatic Intracerebral Hemorrhage after Thrombolytic Therapy with Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke
This study aimed to determine the independent predictors of in-hospital mortality (IHM) and the risk of sICH after rt-PA therapy. A total of 1007 patients (mean age, 72 ± 12 years; 52% women; mean National Institutes of Health Stroke Scale [NIHSS] score, 11.6 ± 5.6) with AIS treated with rt-PA were enrolled in this study during a 42-month period beginning in November 2007. Univariate and multivariate regression analyses were performed to estimate the predictors of IHM. Eighty-three of the 1007 patients (8.2%) died during hospitalization (mean duration of hospitalization, 10 ± 1.8 days). Logistic regression estimated the...
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2012 Category: Neurology Authors: Mohamed Al-Khaled, Christine Matthis, Jürgen Eggers Tags: Original Articles Source Type: research

Warfarin Versus Aspirin for Prevention of Cognitive Decline in Atrial Fibrillation: Randomized Controlled Trial (Birmingham Atrial Fibrillation Treatment of the Aged Study) Clinical Sciences
Conclusions— We found no evidence that anticoagulation confers clinically important protection over aspirin against cognitive decline as measured by the Mini-Mental State Examination in atrial fibrillation in the first 33 months of treatment other than that provided by preventing clinical stroke. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN89345269.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Mavaddat, N., Roalfe, A., Fletcher, K., Lip, G. Y. H., Hobbs, F. D. R., Fitzmaurice, D., Mant, J. Tags: Arrhythmias, clinical electrophysiology, drugs, Primary and Secondary Stroke Prevention, Anticoagulants Clinical Sciences Source Type: research

Abstract 9: Predictors of Poor Outcome in Patients Not Thrombolysed Due to Mild or Resolving Symptoms ("Too Good To Treat") Session Title: Concurrent I Session B: Oral Abstracts on Stroke Topics
Conclusion: A substantial percentage of patients deemed "too good" for IV tPA were unable to be discharged home. Factors such as advanced age and higher NIHSS should be considered in tPA decision-making to optimize outcomes. Large, multi-center prospective studies are underway to study the predictors of poor outcomes in this group.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: Ali, S. F., Faheem, U., Singhal, A. B., Viswanathan, A., Silverman, S. B., Rost, N. S., Schwamm, L. H. Tags: Session Title: Concurrent I Session B: Oral Abstracts on Stroke Topics Source Type: research

Association of Plasma Brain Natriuretic Peptide Levels in Acute Ischemic Stroke Subtypes and Outcome
Brain natriuretic peptide (BNP) is believed to be a diagnostic marker for cardiovascular diseases, including atrial fibrillation (AF). Recent studies have incriminated BNP as a marker of cardioembolic stroke. We aimed at investigating association of plasma BNP levels in acute ischemic stroke subtypes and their outcome in Indian patients.
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2014 Category: Neurology Authors: Jaydip Ray Chaudhuri, Vijay Kumar Sharma, Kandadai Rukmini Mridula, Banda Balaraju, Venkata Chandra Sekher Srinivasarao Bandaru Source Type: research

Anticoagulant Treatment in Patients with Atrial Fibrillation and Ischemic Stroke
Atrial fibrillation (AF) is the most common cardiac dysrhythmia, with a lifetime risk of 25%, and it is a well-known independent risk factor for ischemic stroke. Over the last 15 years, efforts have been made to initiate relevant treatment in patients with AF. A retrospective study was set up to clarify whether this effort has resulted in a decreased proportion of patients with known AF experiencing an ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2015 Category: Neurology Authors: Nicole Scheldon Brunner Frandsen, Andreas Dammann Andersen, Hamoun Ashournia, Ivan Brandslund, Jens Ole Kjærsgaard, Ole Jakob Vilholm Source Type: research

Early Stroke Risk after Transient Ischemic Attack in Patients Without Large-Artery Disease or Atrial Fibrillation
Patients with transient ischemic attack (TIA) without large-artery disease (LAD) or atrial fibrillation (AF) on admission may be at higher risk of stroke than previously thought. The aim of this study was to investigate early stroke risk and its predictors in such patients.
Source: Journal of Stroke and Cerebrovascular Diseases - April 23, 2015 Category: Neurology Authors: Tomoyuki Ohara, Toshiyuki Uehara, Kazunori Toyoda, Rieko Suzuki, Shoichiro Sato, Kazuyuki Nagatsuka, Kazuo Minematsu Source Type: research