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Has the difference in mortality between percutaneous coronary intervention and coronary artery bypass grafting in people with heart disease and diabetes changed over the years? A systematic review and meta-regression
Conclusions The difference in outcome between PCI and CABG in diabetics has not narrowed from the beginning—with balloon angioplasty to current PCI—with the second generation of drug eluting stents. In contrast to the non-diabetics, there is a persistent 30% benefit in all cause mortality favouring CABG in diabetics, and this should be a major factor in treatment recommendation.
Source: BMJ Open - December 30, 2015 Category: Journals (General) Authors: Herbison, P., Wong, C.-K. Tags: Open access, Cardiovascular medicine, Diabetes and Endocrinology Research Source Type: research

Multifactorial intervention to prevent cardiovascular disease in patients with early rheumatoid arthritis: protocol for a multicentre randomised controlled trial
In this study, we compare the effect of a targeted, intensified, multifactorial intervention with that of conventional treatment of modifiable risk factors for cardiovascular disease (CVD) in patients with early RA fulfilling the 2010 American College of Rheumatology European League Against Rheumatism (ACR/EULAR) criteria. Methods and analysis The study is a prospective, randomised, open label trial with blinded end point assessment and balanced randomisation (1:1) conducted in 10 outpatient clinics in Denmark. The primary end point after 5 years of follow-up is a composite of death from cardiovascular causes, non-fa...
Source: BMJ Open - April 19, 2016 Category: Journals (General) Authors: Svensson, A. L., Christensen, R., Persson, F., Logstrup, B. B., Giraldi, A., Graugaard, C., Fredberg, U., Blegvad, J., Thygesen, T., Hansen, I. M. J., Colic, A., Bagdat, D., Ahlquist, P., Jensen, H. S., Horslev-Petersen, K., Sheetal, E., Christensen, T. G Tags: Open access, Cardiovascular medicine, Rheumatology Protocol Source Type: research

Glycosylated haemoglobin as a predictor of cardiovascular events and mortality: a protocol for a systematic review and meta-analysis
Introduction Glycosylated haemoglobin level (HbA1c) is an indicator of the average blood glucose concentrations over the preceding 2–3 months and is used as a convenient and well-known biomarker in clinical practice. Currently, epidemiological evidence suggests that HbA1c level is an independent risk factor for cardiovascular events such as myocardial infarction, stroke, coronary heart disease and heart failure. This protocol aim is to conduct a systematic review and meta-analysis to determine relationships of HbA1c levels with cardiovascular outcomes and cause of death, and to analyse the range of HbA1c levels ...
Source: BMJ Open - July 10, 2016 Category: Journals (General) Authors: Cavero-Redondo, I., Peleteiro, B., Alvarez-Bueno, C., Rodriguez-Artalejo, F., Martinez-Vizcaino, V. Tags: Open access, Cardiovascular medicine, Epidemiology, Public health, Diabetes and Endocrinology Protocol Source Type: research

Regional trends in avoidable hospitalisations due to complications among population with diabetes in Finland in 1996-2011: a register-based cohort study
Conclusions Our study suggests that the prevention of complications among persons with diabetes has improved in Finland between 1996 and 2011. The results further suggest that the prevention of complications has become more uniform throughout the country.
Source: BMJ Open - August 21, 2016 Category: Journals (General) Authors: Manderbacka, K., Arffman, M., Lumme, S., Lehikoinen, M., Winell, K., Keskimäki, I. Tags: Open access, Health services research, Diabetes and Endocrinology Source Type: research

Cross-sectional study on the relationship between the level of serum cystatin C and blood pressure reverse dipping in hypertensive patients
Conclusions The s-CC level was significantly higher in the reverse-dipper group than the dipper group and that s-CC was associated with the reverse-dipper pattern of BP examined with 24 hour ABPM.
Source: BMJ Open - September 1, 2016 Category: Journals (General) Authors: Han, J., Gao, Y., Guo, Q., Su, D., Yan, B., Peng, L., Du, Y., Li, K., Wang, G. Tags: Open access, Cardiovascular medicine, Renal medicine Research Source Type: research

Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details
Conclusions Despite widespread multimorbidity, more than three-quarters of ongoing trials assessing interventions for patients with chronic conditions excluded patients with concomitant chronic conditions.
Source: BMJ Open - September 26, 2016 Category: Journals (General) Authors: Buffel du Vaure, C., Dechartres, A., Battin, C., Ravaud, P., Boutron, I. Tags: Open access, Evidence based practice, General practice / Family practice, Research methods Source Type: research

Hospital-diagnosed atopic dermatitis and long-term risk of myocardial infarction: a population-based follow-up study
Conclusions Hospital-diagnosed AD was associated with increased risk of MI compared with the general population.
Source: BMJ Open - November 10, 2016 Category: Journals (General) Authors: Riis, J. L., Vestergaard, C., Hjuler, K. F., Iversen, L., Jakobsen, L., Deleuran, M. S., Olsen, M. Tags: Open access, Cardiovascular medicine, Dermatology Research Source Type: research

Pioglitazone and cardiovascular outcomes in patients with insulin resistance, pre-diabetes and type 2 diabetes: a systematic review and meta-analysis
Conclusions Pioglitazone was associated with reduced risk of MACE in people with insulin resistance, pre-diabetes and diabetes mellitus. However, the risks of heart failure, bone fracture, oedema and weight gain were increased.
Source: BMJ Open - January 4, 2017 Category: Journals (General) Authors: Liao, H.-W., Saver, J. L., Wu, Y.-L., Chen, T.-H., Lee, M., Ovbiagele, B. Tags: Open access, Cardiovascular medicine, Diabetes and Endocrinology Research Source Type: research

Comparison of self-perceived cardiovascular disease risk among smokers with Framingham and PROCAM scores: a cross-sectional analysis of baseline data from a randomised controlled trial
Conclusions Among smokers, misperception of their 10-year cardiovascular risk is common, with one-fifth underestimating it. These findings may help physicians target patients with such characteristics to help them change their health behaviour and adherence to risk-reduction therapy. Trial registration number NCT00548665; Post-results.
Source: BMJ Open - January 5, 2017 Category: Journals (General) Authors: Desgraz, B., Collet, T.-H., Rodondi, N., Cornuz, J., Clair, C. Tags: Open access, Cardiovascular medicine, Epidemiology, General practice / Family practice, Smoking and tobacco Research Source Type: research

Healthcare organisation and delivery for people with dementia and comorbidity: a qualitative study exploring the views of patients, carers and professionals
Conclusions This study suggests that, in order to improve access and continuity for PLWD and comorbidity, a significant change in the organisation of care is required which involves: coproduction of care where professionals, PLWD and family carers work in partnership; recognition of the way a patient's diagnosis of dementia affects the management of other long-term conditions; flexibility in services to ensure they are sensitive to the changing needs of PLWD and their family carers over time; and improved collaboration across specialities and organisations. Research is needed to develop interventions that support partnersh...
Source: BMJ Open - January 17, 2017 Category: Journals (General) Authors: Bunn, F., Burn, A.-M., Robinson, L., Poole, M., Rait, G., Brayne, C., Schoeman, J., Norton, S., Goodman, C. Tags: Open access, Health services research, Neurology, Qualitative research Source Type: research

Factors related to receipt of non-cancer-related transurethral prostatectomy: findings from a large prospective study of 106 769 middle-aged and older Australian men
Conclusions TURP rates were most strongly related to baseline LUTS and age, consistent with appropriate health services targeting. Lower TURP rates in men experiencing socioeconomic disadvantage and with poor health/disability, after accounting for baseline LUTS, suggest inequity and factors such as frailty and risks related to surgery.
Source: BMJ Open - February 7, 2017 Category: Journals (General) Authors: Joshy, G., Soga, K., Korda, R. J., Patel, M. I., Banks, E. Tags: Open access, Epidemiology, Health services research, Surgery, Urology Source Type: research

94: online management of metabolic syndrome and cardiovascular risk factors: a simple method for awareness and actions
Conclusion: Effective and affordable strategies to control the syndrome could benefit the at risk population. The integration of interactive e-health programs to primary health care practices such as prevention of cardiovascular risk factors offers possibilities for on- time interaction with the target group. The use of web-based approaches is a great interest in the management of patients at high cardiovascular risk, especially in a scenario where the prevalence of obesity, metabolic syndrome and diabetes is increasing.
Source: BMJ Open - February 7, 2017 Category: Journals (General) Authors: Jahangiry, L., Farhangi, A., Najafi, M. Tags: Open access Poster Source Type: research

Translating the WHO 25x25 goals into a UK context: the PROMISE modelling study
Conclusions The global premature mortality targets are a potentially achievable goal for countries such as the UK that can capitalise on many decades of effort in prevention and treatment. High morbidity diseases and diseases in later life are not addressed in the Global NCD Action Plan and targets, but must also be considered a priority for prevention in the UK where the population is ageing and the costs of health and social care are rising.
Source: BMJ Open - April 4, 2017 Category: Journals (General) Authors: Cobiac, L. J., Scarborough, P. Tags: Open access, Epidemiology, Health policy, Public health Research Source Type: research

Efficacy of a glucagon-like peptide-1 agonist and restrictive versus liberal oxygen supply in patients undergoing coronary artery bypass grafting or aortic valve replacement: study protocol for a 2-by-2 factorial designed, randomised clinical trial
The objective of this study is to determine the efficacy of the GLP-1-analogue exenatide versus placebo and restrictive oxygenation (50% fractional inspired oxygen, FiO2) versus liberal oxygenation (100% FiO2) in patients undergoing open heart surgery. Methods and analysis A randomised, placebo-controlled, double blind (for the exenatide intervention)/single blind (for the oxygenation strategy), 2x2 factorial designed single-centre trial on adult patients undergoing elective or subacute CABG and/or surgical AVR. Patients will be randomised in a 1:1 and 1:1 ratio to a 6-hour and 15 min infusion of 17.4 µg of exenatid...
Source: BMJ Open - November 5, 2021 Category: General Medicine Authors: Wiberg, S., Kjaergaard, J., Mogelvang, R., Moller, C. H., Kandler, K., Ravn, H., Hassager, C., Kober, L., Nilsson, J. C. Tags: Open access, Surgery Source Type: research

wEight chanGes, caRdio-mEtabolic risks and morTality in patients with hyperthyroidism (EGRET): a protocol for a CPRD-HES linked cohort study
Introduction Hyperthyroidism is a common condition affecting up to 3% of the UK population. Treatment improves symptoms and reduces the risk of atrial fibrillation and stroke that contribute to increased mortality. The most common symptom is weight loss, which is reversed during treatment. However, the weight regain may be excessive, contributing to increased risk of obesity. Current treatment options include antithyroid drugs, radioiodine and thyroidectomy. Whether there are differences in either weight change or the long-term cardiometabolic risk between the three treatments is unclear. Methods and analysis The study wi...
Source: BMJ Open - October 1, 2021 Category: General Medicine Authors: Torlinska, B., Hazlehurst, J. M., Nirantharakumar, K., Thomas, G. N., Priestley, J. R., Finnikin, S. J., Saunders, P., Abrams, K. R., Boelaert, K. Tags: Open access, Diabetes and Endocrinology Source Type: research

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