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Source: BMJ Open
Condition: Diabetes

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Total 89 results found since Jan 2013.

Intensive versus standard blood pressure control in type 2 diabetes: a restricted mean survival time analysis of a randomised controlled trial
Conclusions Intensive BP treatment may reduce death and cardiovascular events among patients with type 2 diabetes receiving standard glycaemic treatment and without cognitive impairment. Trial registration number NCT00000620; Post-results.
Source: BMJ Open - September 13, 2021 Category: General Medicine Authors: Shi, S., Gouskova, N., Najafzadeh, M., Wei, L.-J., Kim, D. H. Tags: Open access, Cardiovascular medicine Source Type: research

Factors influencing the readiness to tackle the burden of ischaemic heart disease in India: a systematic review protocol
This study, being a systematic review, does not involve any clinical trial, primary data collection or empirical study involving humans or animals. Therefore, no ethical permissions were sought by reviewers. PROSPERO registration number CRD42020219490.
Source: BMJ Open - August 19, 2021 Category: General Medicine Authors: Bhattacharjee, S., Yaghmaei, N., Phuong, C. T. L., Neupane, D. Tags: Open access, Public health Source Type: research

Association of depressive symptoms with the progression of carotid intima-media thickness in a community-based cohort in Beijing, China
Conclusion Depressive symptoms were independently associated with progression of mean cIMT in a community-based cohort in Beijing, China. Furthermore, this relationship was modified by drinking status.
Source: BMJ Open - August 17, 2021 Category: General Medicine Authors: Liu, M., Jia, J., Fan, F., Sun, P., Wu, Z., Jiang, Y., He, D., Liu, B., Yang, Y., Zhang, Y. Tags: Open access, Cardiovascular medicine Source Type: research

Pentoxifylline in diabetic kidney disease (VA PTXRx): protocol for a pragmatic randomised controlled trial
This study was approved by the VA Central Institutional Review Board (cIRB/18-36) and will be conducted in compliance with the Declaration of Helsinki and the Guidelines for Good Clinical Practice. The Hines Cooperative Studies Programme will finalise the study results, which will be published in accordance with the Consolidated Standards of Reporting Trials statement in a peer-reviewed scientific journal. Trial registration number NCT03625648.
Source: BMJ Open - August 16, 2021 Category: General Medicine Authors: Leehey, D. J., Carlson, K., Reda, D. J., Craig, I., Clise, C., Conner, T. A., Agarwal, R., Kaufman, J. S., Anderson, R. J., Lammie, D., Huminik, J., Polzin, L., McBurney, C., Huang, G. D., Emanuele, N. V. Tags: Open access, Renal medicine Source Type: research

Danish validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ) and findings from a population health survey: a mixed-methods study
Conclusion The Danish MTBQ is a valid measure of treatment burden with good construct validity and high internal reliability. This is the first study to explore treatment burden at a population level and provides important evidence to policy makers and clinicians about sociodemographic groups at risk of higher treatment burden.
Source: BMJ Open - January 3, 2022 Category: General Medicine Authors: Pedersen, M. H., Duncan, P., Lasgaard, M., Friis, K., Salisbury, C., Breinholt Larsen, F. Tags: Open access, Research methods Source Type: research

Comparison of the effects on cardiovascular events between use of metformin and dipeptidyl peptidase-4 inhibitors as the first-line hypoglycaemic agents in Japanese patients with type 2 diabetes mellitus: a claims database analysis
Conclusions Patients who received metformin as first-line therapy may have reduced cardiovascular events than those receiving DPP-4i. This study conforms to previous Japanese database studies, despite the consideration of its limitation being an observational design.
Source: BMJ Open - March 11, 2022 Category: General Medicine Authors: Nishimura, R., Takeshima, T., Iwasaki, K., Aoi, S. Tags: Open access, Diabetes and Endocrinology Source Type: research

Cohort profile: Outcomes & Multi-morbidity In Type 2 diabetes (OMIT) - a national registry-based observational cohort with focus on care and treatment of key high-risk groups in Norway
Purpose The ‘Outcomes & Multi-morbidity in Type 2 Diabetes’ (OMIT) is an observational registry-based cohort of Norwegian patients with type 2 diabetes (T2D) established to study high-risk groups often omitted from randomised clinical trials. Participants The OMIT cohort includes 57 572 patients with T2D identified via linkage of Norwegian Diabetes Register for Adults and the Rogaland-Oslo-Salten-Akershus-Hordaland study, both offering data on clinical patient characteristics and drug prescriptions. Subsequently these data are further linked to the Norwegian Prescription Database for dispensed medications,...
Source: BMJ Open - May 11, 2022 Category: General Medicine Authors: Forster, R. B., Strandberg, R. B., Bo Tibballs, K. L., Nokleby, K., Berg, T. J., Iversen, T., Hagen, T. P., Richardsen, K. R., Cooper, J., Sandberg, S., Lovaas, K. F., Nilsen, R. M., Iversen, M. M., Jenum, A. K., Buhl, E. S. S. Tags: Open access, Diabetes and Endocrinology Source Type: research

Decreasing rates of cost-related medication non-adherence by age advancement among American generational cohorts 2004-2014: a longitudinal study
Conclusion The paradox of decreasing CRN rates, independent of disease burden, income and insurance status, suggests populations’ CRN behaviours change as Americans age, bearing implications to social policy.
Source: BMJ Open - May 6, 2022 Category: General Medicine Authors: Zhang, J., Bhaumik, D., Meltzer, D. Tags: Open access, Health economics Source Type: research

Public perceptions of brain health: an international, online cross-sectional survey
Conclusions Differences in perceptions of brain health were noted among specific segments of the population. Policies providing information about brain-friendly health behaviours and targeting people less likely to have relevant experience may be needed.
Source: BMJ Open - April 18, 2022 Category: General Medicine Authors: Budin-Ljosne, I., Mowinckel, A. M., Friedman, B. B., Ebmeier, K. P., Drevon, C. A., Carver, R. B., Zsoldos, E., Fredheim, N. A. G., Sorensen, O., Baare, W. F. C., Madsen, K. S., Fjell, A. M., Kievit, R. A., Ghisletta, P., Bartres-Faz, D., Nawijn, L., Sole Tags: Open access, Public health Source Type: research

Prevalence and associated relating factors in patients with hereditary retinal dystrophy: a nationwide population-based study in Taiwan
Conclusions 74% of the diagnosed HRD are retinitis pigmentosa. Population-based data suggested an increased incidence of cataract in younger patients, whereas older HRD patients are more susceptible to develop CME. Further work is needed to elucidate the mechanism between these ophthalmological disorders and HRD.
Source: BMJ Open - April 8, 2022 Category: General Medicine Authors: Woon, P. Y., Chien, J.-Y., Wang, J.-H., Chou, Y.-Y., Lin, M.-C., Huang, S.-P. Tags: Open access, Ophthalmology Source Type: research

Experiences and actions related to living with type 1 diabetes during the COVID-19 pandemic in Norway: a qualitative study conducted during July to December 2020
Conclusions Patients experienced an increased psychosocial burden of T1DM and difficulties from a disrupted daily life affecting T1DM self-management routines. Uncertainty-reducing behaviours and actions to adapt to the situation provided a general sense of coping despite these difficulties. Tailored information and follow-up by telephone or video call was emphasised to reduce uncertainly distress and support adequate diabetes T1DM self-management.
Source: BMJ Open - April 7, 2022 Category: General Medicine Authors: Pleym, K., Iversen, M. M., Broström, A. Tags: Open access, Diabetes and Endocrinology, COVID-19 Source Type: research

249 The association of comorbidities and survival after out-of-hospital cardiac arrest in Denmark
ConclusionComorbidities significantly influence survival of OHCA patients. Cardiovascular comorbidities constitute the major part of the disease burden. The influence of comorbidity should be included in future treatment guidelines of OHCA patients.Conflict of interestNone.FundingNone.
Source: BMJ Open - May 1, 2022 Category: General Medicine Authors: Sodergren, S., Moller, S., Pedersen, C., Folke, F., Ersboll, A. Tags: Open access Cardiac arrest Source Type: research

Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years
Conclusions This is an under-reported research area and the findings suggest the codes’ usage diversity for most conditions remained overall stable throughout the study period. Generated mental health code lists can last for a long time unlike cardiometabolic conditions and cancer. Adopting more consistent and less diverse coding would help improve data quality in primary care. Future research is needed following the transfer to the Systematised Nomenclature of Medicine Clinical Terms (SNOMED CT) coding.
Source: BMJ Open - July 25, 2022 Category: General Medicine Authors: Zghebi, S. S., Reeves, D., Grigoroglou, C., McMillan, B., Ashcroft, D. M., Parisi, R., Kontopantelis, E. Tags: Open access, General practice / Family practice Source Type: research

Impact of multimorbidity and complex multimorbidity on mortality among older Australians aged 45 years and over: a large population-based record linkage study
Conclusion MM and CMM were common in older Australian adults; and MM was a better predictor of all-cause mortality risk than CMM. Higher mortality risk in those aged 45–59 years indicates tailored, person-centred integrated care interventions and better access to holistic healthcare are needed for this age group.
Source: BMJ Open - July 26, 2022 Category: General Medicine Authors: Kabir, A., Tran, A., Ansari, S., Conway, D. P., Barr, M. Tags: Open access, Geriatric medicine Source Type: research

Reporting dose in complex self-management support interventions for long-term conditions: is it defined by researchers and received by participants? A systematic review
Conclusions Interpreting results and implementing effective complex self-management interventions is difficult when researchers’ reporting of dose is not in line with guidelines. If trial findings indicate benefit from the intervention, clear reporting of dose ensures reliable implementation to standard care. If the results are non-significant, detailed reporting enables better interpretation of results, that is, differentiating between poor implementation and lack of effectiveness. This ensures quality of interventions and validity and generalisability of trial findings. Therefore, wider adoption of reporting the TI...
Source: BMJ Open - August 17, 2022 Category: General Medicine Authors: Rookes, T. A., Barat, A., Turner, R., Taylor, S. Tags: Open access, Evidence based practice Source Type: research