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The short- and long-term efficacy of intravascular stenting in the treatment of intracranial artery stenosis
CONCLUSION: The short- and long-term efficacy of intravascular stenting in the treatment of intracranial artery stenosis is significant. What's more, a history of coronary heart disease and advanced age (≥70 years) are independent risk factors contributing to postoperative restenosis.PMID:34306471 | PMC:PMC8290700
Source: American Journal of Translational Research - July 26, 2021 Category: Research Authors: Qiang Jia Shixin Yan Source Type: research

DPP-4 inhibitor saxagliptin ameliorates oxygen deprivation/reoxygenation-induced brain endothelial injury.
In this study, we reveal that saxagliptin, one of the most widely used DPP-4 inhibitors, exhibits vascular protective effects against oxygen and glucose depletion/reoxygenation (OGD/R) in human brain vascular endothelial cells. Our data show that DPP-4 is fairly expressed in brain endothelial cells and its expression is induced by OGD/R. The results of MTT assay show that inhibition of DPP-4 by saxagliptin ameliorates OGD/R-induced reduced cell viability, and LDH assay demonstrated that saxagliptin reduces cellular toxicity. Furthermore, we show that saxagliptin mitigates OGD/R-induced collapse of mitochondrial membrane po...
Source: American Journal of Translational Research - November 20, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Predicting venous thromboembolism in non-surgical hospitalized patients with type 2 diabetes mellitus: development and validation of a nomogram
CONCLUSIONS: A predictive nomogram for VTE in non-surgical inpatients with T2DM was developed and validated in this study. The nomogram is highly predictive and easy to operate, but external data verification is required before it can be further used.PMID:36915788 | PMC:PMC10006801
Source: American Journal of Translational Research - March 14, 2023 Category: Research Authors: Xiaoyi Dun Qinfen Wu Yiming Ma Wenjiang Hu Xiaojing Zuo Source Type: research

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