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Exploring the Recent Trends in Management of Dementia and Frailty: Focus on Diagnosis and Treatment
Curr Med Chem. 2022 Apr 8. doi: 10.2174/0929867329666220408102051. Online ahead of print.ABSTRACTDementia and frailty increase health adversities in older adults, which are topics of growing research interest. Frailty is considered to correspond to a biological syndrome associated with age. Frail patients may ultimately develop multiple dysfunctions across several systems, including stroke, transient ischemic attack, vascular dementia, Parkinson's disease, Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, cortico-basal degeneration, multiple system atrophy, amyotrophic lateral sclerosis, and Creutzfe...
Source: Current Medicinal Chemistry - April 11, 2022 Category: Chemistry Authors: Md Mominur Rahman Sadia Afsana Mim Md Rezaul Islam Anwar Parvez Fahadul Islam Mohammad Borhan Uddin Md Saidur Rahaman Pollob Ahmed Shuvo Muniruddin Ahmed Nigel H Greig Mohammad Amjad Kamal Source Type: research

Guhong Injection Prevents Ischemic Stroke-Induced Neuro-Inflammation and Neuron Loss Through Regulation of C5ar1
In this study, the neuroprotective effect of Guhong injection (GHI) on middle cerebral artery occlusion (MCAO)-induced reperfusion injury was assessed and the mechanism was explored by RNA-seq technology. GHI administered for 6 consecutive days significantly decreased body weight loss, infarction rate, neurological deficient scores, and neuron loss but improved rat survival percentage and regional cerebral blood flow after MCAO surgery. Furthermore, we identified inflammation as a vital process and C5AR1 as a vital target in GHI-mediated protection by using RNA-seq analysis. Further experiments confirmed that GHI decreased...
Source: Frontiers in Pharmacology - March 21, 2022 Category: Drugs & Pharmacology Source Type: research

Weight Change Since Age 20 and the Risk of Cardiovascular Disease Mortality: A Prospective Cohort Study
CONCLUSION: Weight loss, especially when moving from normal to underweight, was associated with the increased risk of CVD mortality.PMID:34803086 | DOI:10.5551/jat.63191
Source: Journal of Atherosclerosis and Thrombosis - November 22, 2021 Category: Cardiology Authors: Ahmed Arafa Yoshihiro Kokubo Haytham A Sheerah Yukie Sakai Emi Watanabe Jiaqi Li Kyoko Honda-Kohmo Masayuki Teramoto Rena Kashima Masatoshi Koga Source Type: research

Potential impact of gradual reduction of fat content in manufactured and out-of-home food on obesity in the United Kingdom: a modeling study
ConclusionsA modest fat reduction (particularly in SFA) in widely consumed foods would prevent obesity, type 2 diabetes, and cardiovascular disease.
Source: American Journal of Clinical Nutrition - May 8, 2021 Category: Nutrition Source Type: research

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