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Associations of Serum 25(OH)D with Risk of Recurrent Cardiovascular Events in Individuals with Coronary Heart Disease
This study aimed to investigate the associations of serum 25-hydroxyvitamin D [25(OH)D] concentration and the vitamin D receptor (VDR) polymorphisms with the risk of recurrent cardiovascular events in individuals with established CHD.METHODS: A total of 22,571 participants with CHD were included from the UK Biobank. Recurrent cardiovascular events, including myocardial infarction (MI), heart failure (HF), stroke, and CVD mortality, were identified from electronic health records. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS: The median (interquartile ra...
Source: The Journal of Clinical Endocrinology and Metabolism - June 6, 2023 Category: Endocrinology Authors: Xiaoyu Lin Xue Chen Sen Liu Yulei Deng Yuexuan Wang Qi Lu Rui Li Yunjing Ou Qingying Tian Yunfei Liao Guanglin Cui Kun Yang An Pan Gang Liu Source Type: research

Vitamin D status, genetic factors, and risk of cardiovascular disease among individuals with type 2 diabetes: a prospective study
CONCLUSIONS: Higher serum 25(OH)D concentrations were significantly associated with lower risks of total CVD and IHD among patients with T2D, regardless of genetic susceptibility and genetic variants in VDR. Risk reductions tended to plateau at serum 25(OH)D levels around 50 nmol/L. These findings suggest that maintaining adequate vitamin D status and avoiding deficiency may help to prevent CVD complications among patients with T2D.PMID:35771998 | DOI:10.1093/ajcn/nqac183
Source: The American Journal of Clinical Nutrition - June 30, 2022 Category: Nutrition Authors: Zhenzhen Wan Tingting Geng Rui Li Xue Chen Qi Lu Xiaoyu Lin Liangkai Chen Yanjun Guo Liegang Liu Zhilei Shan An Pan JoAnn E Manson Gang Liu Source Type: research