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Genetics of hyperhomocysteinemia and 1-carbon metabolism: implications for retinal structure and eye functions.
Abstract Homocysteine (Hcy); a sulfur-containing non-proteinogenic amino acid is generated as a metabolic intermediate. Hcy constitutes an important part of the "1-carbon metabolism" during methionine turnover. Elevated levels of Hcy known as hyperhomocysteinemia (HHcy) results from vitamin B deficiency, lack of exercise, smoking, excessive alcohol intake, high fat and methionine rich diet, and the underlying genetic defects. These factors directly affect the "1-carbon metabolism (methionine-Hcy-folate)" of a given cell. In fact, the Hcy levels are determined primarily by dietary intake, vitamin status, and the ge...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2019 Category: Drugs & Pharmacology Authors: George AK, Majumder A, Ice H, Homme RP, Eyob W, Tyagi SC, Singh M Tags: Can J Physiol Pharmacol Source Type: research

Clinical study on anti-epileptic drug with B vitamins for the treatment of epilepsy after stroke.
CONCLUSIONS: Anti-epilepsy drugs combined with B vitamins can improve epilepsy control after stroke and reduce new stroke occurrence. This effect may be associated with stability of plasma ADMA levels. Vitamin B12 may be better than vitamin B complex in the treatment of epilepsy after stroke. PMID: 28770947 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - August 6, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research