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Genetics of hyperhomocysteinemia and 1-carbon metabolism: implications for retinal structure and eye functions.
Abstract Homocysteine (Hcy); a sulfur-containing non-proteinogenic amino acid is generated as a metabolic intermediate. Hcy constitutes an important part of the "1-carbon metabolism" during methionine turnover. Elevated levels of Hcy known as hyperhomocysteinemia (HHcy) results from vitamin B deficiency, lack of exercise, smoking, excessive alcohol intake, high fat and methionine rich diet, and the underlying genetic defects. These factors directly affect the "1-carbon metabolism (methionine-Hcy-folate)" of a given cell. In fact, the Hcy levels are determined primarily by dietary intake, vitamin status, and the ge...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2019 Category: Drugs & Pharmacology Authors: George AK, Majumder A, Ice H, Homme RP, Eyob W, Tyagi SC, Singh M Tags: Can J Physiol Pharmacol Source Type: research

Effects of differences in serum total homocysteine, folate, and vitamin B 12 on cognitive impairment in stroke patients
Conclusion: The tHcy levels were significantly higher and the vitamin B12 and folate levels were significantly lower in the patients with VCIND than those in the other groups. The high tHcy levels in the VCIND patients may be correlated with impaired cognitive function.
Source: BMC Neurology - November 30, 2014 Category: Neurology Authors: Bo JiangYumei ChenGuoen YaoCunshan YaoHongmei ZhaoXiangdong JiaYunyan ZhangJunling GeEnchao QiuChengyun Ding Source Type: research

Vitamin B may reduce risk of stroke
Researchers have uncovered evidence that suggests vitamin B supplements could help to reduce the risk of stroke, according to a study published in the journal Neurology. Vitamin B supplements are said to be beneficial for many health issues, including stress, anxiety, depression, dementia, Alzheimer's disease and heart disease. However, according to Xu Yuming of Zhengzhou University in Zhengzhou, China, previous studies have conflicting findings regarding the use of vitamin B supplements and stroke or heart attack...
Source: Health News from Medical News Today - September 19, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Peering into genetic defects, CU scientists discover a new metabolic disease called cobalimin X, or cblX
An international team of scientists, including University of Colorado School of Medicine and Children's Hospital Colorado researchers, has discovered a new disease related to an inability to process Vitamin B12. The disorder is rare but can be devastating. "Some people with rare inherited conditions cannot process vitamin B 12 properly," says CU researcher Tamim Shaikh, PhD, a geneticist and senior author of a paper about the new disease. "These individuals can end up having serious health problems, including developmental delay, epilepsy, anemia, stroke, psychosis and dementia...
Source: Health News from Medical News Today - September 9, 2013 Category: Consumer Health News Tags: Endocrinology Source Type: news