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Triglyceride-lowering and Anti-inflammatory Mechanisms of Omega-3 Polyunsaturated Fatty Acids for Atherosclerotic Cardiovascular Risk Reduction
Atherosclerotic cardiovascular disease (ASCVD) is defined as acute coronary syndrome, stable angina, history of myocardial infarction, coronary or other arterial revascularization, ischemic stroke, transient ischemic attack, or peripheral arterial disease presumed to be of atherosclerotic origin.1 Despite continuous advances in medical intervention and surgical therapy for the treatment of ASCVD, the latter remains the leading cause of morbidity and mortality globally. In the United States, nearly 808,000 people died of ASCVD in 2014, translating to about 1 of every 3 deaths,2 and the death rate from ASCVD rose in 2015 by ...
Source: Journal of Clinical Lipidology - June 5, 2021 Category: Lipidology Authors: Qiyuan Keith Liu Tags: Review Article Source Type: research

Survey of the Erythrocyte EPA+DHA Levels in the Heart Attack/Stroke Belt
ConclusionsIndividuals in the CVD “belt” had relatively low O3I levels. Since in other settings, a low O3I is associated with increased risk for CVD, this may be one factor contributing to the higher risk for CVD in this region of the US.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 14, 2019 Category: Lipidology Source Type: research

Effects of fatty and lean fish intake on stroke risk: a meta-analysis of prospective cohort studies
Fish intake has been postulated to reduce the risk of stroke. However, whether the beneficial effect of fish are mainly linked to fat content, as a source of omega-3 polyunsaturated fatty acids, remains unclea...
Source: Lipids in Health and Disease - November 23, 2018 Category: Lipidology Authors: Zhi-Zhen Qin, Jia-Ying Xu, Guo-Chong Chen, Yu-Xia Ma and Li-Qiang Qin Tags: Research Source Type: research

Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids
Publication date: November 2018Source: Prostaglandins & Other Lipid Mediators, Volume 139Author(s): Reheman Adili, Megan Hawley, Michael HolinstatAbstractThrombosis is the most common underlying pathology responsible for morbidity and mortality in cardiovascular disease (CVD). Platelet adhesion, activation, and aggregation play central roles in hemostasis; however, the same process may also cause thrombosis and vessel occlusion at the site of ruptured atherosclerotic lesions leading to heart attack and stroke. ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) are an essential component of the platelet phospholipid membrane...
Source: Prostaglandins and Other Lipid Mediators - October 4, 2018 Category: Lipidology Source Type: research

Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: possible interaction with genes involved in 20-HETE and EETs metabolism
Conclusions Our data do not support a major role of ω-6 or ω-3 PUFA intakes on BP change over time, but suggest a possible interaction of ω-3 PUFA with the CYP4F2 V433M.
Source: Prostaglandins and Other Lipid Mediators - May 17, 2015 Category: Lipidology Source Type: research