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Nutrition: Iron
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Total 14 results found since Jan 2013.
Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research
TUK9Ferrostatin-1 alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3 β signaling pathway
In conclusion, Fer-1 has protective effects on cerebral I/R injury by activating the AKT/GSK3β pathway, indicating that ferroptosis may become a novel target in the treatment of ischemic stroke.PMID:36596364 | DOI:10.1016/j.brainresbull.2022.12.009
Source: Cell Research - January 3, 2023 Category: Cytology Authors: Xinyao Liu Yue Du Jian Liu Linggang Cheng Wen He Wei Zhang Source Type: research
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury
Neurochem Res. 2022 Nov 19. doi: 10.1007/s11064-022-03822-7. Online ahead of print.ABSTRACTFerroptosis is characterized by excessive accumulation of iron and lipid peroxides, which are involved in ischemia, reperfusion-induced organ injury, and stroke. Propofol, an anesthetic agent, has neuroprotective effects due to its potent antioxidant, anti-ischemic, and anti-inflammatory properties. However, the relationship between propofol and ferroptosis is still unclear. In the current study, we elucidated the role of ferroptosis in the neuroprotective effect of propofol in mouse brains subjected to cerebral ischemia reperfusion ...
Source: Cell Research - November 19, 2022 Category: Cytology Authors: Gui-Bo Fan Yan Li Gao-Shuo Xu A-Yang Zhao Hong-Jiang Jin Si-Qi Sun Si-Hua Qi Source Type: research
cPKC γ ameliorates ischemic injury in cultured neurons exposed to oxygen glucose deprivation/reoxygenation by inhibiting ferroptosis
In this study, primary cultured cortical neurons were used to establish 1h oxygen-glucose deprivation (OGD) and reoxygenation (R) 0-12h (i.e., 1h OGD/R 0-12h) as in vitro models of cell ischemia. After 1h OGD/R 0-12h, cyclooxygenase 2 (COX2) and acyl-CoA synthetase long-chain family member 4 (ACSL4) levels increased, and glutathione peroxidase 4 (GPx4) levels decreased significantly. Concurrently, GPx4 activity decreases, and iron levels increased. The inhibition of ferroptosis by Liproxstatin-1 ameliorated OGD-induced neuronal injury. Liproxstatin-1 administration prominently induced GPx4 expression and suppressed COX2 ex...
Source: Cell Research - April 14, 2022 Category: Cytology Authors: Haiping Wei Zhifeng Peng Yahong Chen Jia Guo Lixia Chen Kangmei Shao Source Type: research
Extended Ischemic Recovery After Implantation of Human Mesenchymal Stem Cell Aggregates Indicated by Sodium MRI at 21.1 T
Transl Stroke Res. 2022 Feb 7. doi: 10.1007/s12975-021-00976-4. Online ahead of print.ABSTRACTExtended therapeutic application remains a significant issue in the use of stem cell therapies to treat ischemic stroke. Along these lines, neurological recovery in a rodent model of ischemic stroke was evaluated following implantation of human mesenchymal stem cell aggregates (hMSC-agg), labeled with micron-sized particles of iron oxide, directly into the lateral ventricle contralateral to the ischemic lesion hemisphere. Longitudinally, disease progression and response to hMSC-agg therapy were assessed by 1H and 23Na magnetic res...
Source: Cell Research - February 8, 2022 Category: Cytology Authors: Shannon Helsper F Andrew Bagdasarian Xuegang Yuan Kaya Xu Jea-Young Lee Jens T Rosenberg Cesario V Borlongan Teng Ma Samuel C Grant Source Type: research
Role of Ferroptosis in Stroke
Cell Mol Neurobiol. 2022 Jan 31. doi: 10.1007/s10571-022-01196-6. Online ahead of print.ABSTRACTStroke is a common and serious nervous system disease caused by the rupture or blockage of the cardiovascular system. It causes millions of deaths and disabilities every year, which is a huge burden on humanity. It may be induced by thrombosis, hypertension, hyperlipidemia, hyperglycemia, smoking, advanced age and so on. According to different causes, stroke can be generally divided into hemorrhagic stroke and ischemic stroke, whose pathogenesis and treatment are quite different. Ferroptosis is a new type of cell death first def...
Source: Cellular and Molecular Neurobiology - February 1, 2022 Category: Cytology Authors: Yunfei Xu Kexin Li Yao Zhao Lin Zhou Ying Liu Jie Zhao Source Type: research
Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke
Pharmacol Res. 2021 Oct 8:105933. doi: 10.1016/j.phrs.2021.105933. Online ahead of print.ABSTRACTIschemic stroke poses a significant health risk due to its high rate of disability and mortality. To address this problem, several therapeutic approaches have been proposed, including interruption targeting programmed cell death (PCD). Ferroptosis is a newly defined PCD characterized by iron-dependent accumulation of lipid peroxidation, and is becoming a promising target for treating numerous diseases. To explore the underlying mechanisms of the initiation and execution of ferroptosis in ischemic stroke, we established stroke m...
Source: Cell Research - October 11, 2021 Category: Cytology Authors: Chong Li Guangchi Sun Binglin Chen Lei Xu Yangfan Ye Jinyan He Zhongyuan Bao Pengzhan Zhao Zong Miao Lin Zhao Jingming Hu Yongping You Ning Liu Honglu Chao Jing Ji Source Type: research
Pyridoxal Isonicotinoyl Hydrazone Improves Neurological Recovery by Attenuating Ferroptosis and Inflammation in Cerebral Hemorrhagic Mice
Biomed Res Int. 2021 Sep 8;2021:9916328. doi: 10.1155/2021/9916328. eCollection 2021.ABSTRACTFerroptosis and inflammation induced by cerebral hemorrhage result in an excessive inflammatory response and irreversible neuronal injury. Alleviating ferroptosis might be an effective way to prevent neuroinflammatory injury and promote neural functional recovery. Pyridoxal isonicotinoyl hydrazine (PIH), a lipophilic iron-chelating agent, has been reported to reduce excess iron-induced cytotoxicity. However, whether PIH could ameliorate the effects of hemorrhagic stroke is not completely understood. In the present study, the preven...
Source: Cell Research - September 20, 2021 Category: Cytology Authors: Hengli Zhang Min Wen Jiayu Chen Chaojie Yao Xiao Lin Zhongxiao Lin Junnan Ru Qichuan Zhuge Su Yang Source Type: research
Inhibition of Ferroptosis Alleviates Early Brain Injury After Subarachnoid Hemorrhage In Vitro and In Vivo via Reduction of Lipid Peroxidation.
Abstract
Subarachnoid hemorrhage (SAH) is a serious cerebrovascular disease with high mortality, and the mean age at morbidity is younger than in other types of stroke. Early brain injury (EBI) plays a key role in the poor prognoses of SAH. In EBI, multiple forms of cell death have been identified and well studied; however, the role of ferroptosis has not been elucidated. Hence, in this study, we developed an in vivo (SAH rat model) and in vitro model (SH-SY5Y oxyhemoglobin injury model) to understand the role of ferroptosis in EBI, then explored the protective mechanism of ferrostatin-1 (Fer-1). Firstly, we found...
Source: Cellular and Molecular Neurobiology - April 19, 2020 Category: Cytology Authors: Li Y, Liu Y, Wu P, Tian Y, Liu B, Wang J, Bihl J, Shi H Tags: Cell Mol Neurobiol Source Type: research
Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke.
This study reports isolation of viable human amniotic fluid-derived stem cells, labeled with multimodal iron oxide nanoparticles, and its effect on focal cerebral ischemia-reperfusion injury in Wistar rats. Middle cerebral artery occlusion of 60 min followed by reperfusion for 1 h, 6 h, and 24 h was employed in the present study to produce ischemia and reperfusion-induced cerebral injury in rats. Tests were employed to assess the functional outcome of the sensorimotor center activity in the brain, through a set of modified neurological severity scores used to assess motor and exploratory capacity 24 h, 14, and 28 days afte...
Source: Cell Transplantation - June 3, 2019 Category: Cytology Authors: Sibov TT, Pavon LF, Cabral FR, Cunha IF, de Oliveira DM, de Souza JG, Marti LC, da Cruz EF, Malheiros JM, Paiva FF, Tannús A, de Oliveira SM, da Costa MDS, Dastoli PA, Mendonça JN, de Toledo SRC, Malheiros SMF, de Paiva Neto MA, Rego NBB, Moron AF, Cava Tags: Cell Transplant Source Type: research
MRI Tracking of iPS Cells-Induced Neural Stem Cells in Traumatic Brain Injury Rats.
In conclusion, using an in vivo MRI tracking technique to trace the fate of iPS cells-induced NSCs in host brain is feasible.
PMID: 30574806 [PubMed - as supplied by publisher]
Source: Cell Transplantation - December 21, 2018 Category: Cytology Authors: Jiang L, Li R, Tang H, Zhong J, Sun H, Tang W, Wang H, Zhu J Tags: Cell Transplant Source Type: research
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Publication date: 5 October 2017 Source:Cell, Volume 171, Issue 2 Author(s): Brent R. Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I. Bush, Marcus Conrad, Scott J. Dixon, Simone Fulda, Sergio Gascón, Stavroula K. Hatzios, Valerian E. Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E. Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C. Pagnussat, Jason Park, Qitao Ran, Craig S. Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M. Torti, Suzy V. Torti, Shinya Toyokuni, K.A. Woerpel, Donna D. Zhang Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation...
Source: Cell - October 29, 2017 Category: Cytology Source Type: research
