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Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion
Sci Adv. 2022 Feb 4;8(5):eabl8920. doi: 10.1126/sciadv.abl8920. Epub 2022 Feb 2.ABSTRACTDexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction, and stroke, all of which are triggered by glutathione (GSH) depletion. GSH levels were significantly decreased by dexamethasone. Mechanistically, we identified that dexamethasone up-regulated the GSH metabolism regulating protein dipeptidase-1 ...
Source: Adv Data - February 2, 2022 Category: Epidemiology Authors: Anne von M ässenhausen Nadia Zamora Gonzalez Francesca Maremonti Alexia Belavgeni Wulf Tonnus Claudia Meyer Kristina Beer Monica T Hannani Arthur Lau Mirko Peitzsch Paul Hoppenz Sophie Locke Triantafyllos Chavakis Rafael Kramann Daniel A Muruve Christian Source Type: research

Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment.
Authors: Lu X, Zhang Y, Wang L, Li G, Gao J, Wang Y Abstract The development of suitable drug delivery carriers is significant in biomedical applications to improve the therapeutic efficiency. Recent progress in nanotechnological fields, paved the way for the formulation of variety of drug carriers. The brain disorders such as ischemic stroke, brain cancer, and CNS disorders were poorly treated due to the presence of blood brain barrier that hinders the passage of drugs to the brain. Hence, the formulated drugs should have the ability to cross the blood-brain barrier (BBB) for ischemic stroke treatment. In the pres...
Source: Drug Delivery - February 17, 2021 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Molecules, Vol. 23, Pages 1406: Dexamethasone-Loaded, PEGylated, Vertically Aligned, Multiwalled Carbon Nanotubes for Potential Ischemic Stroke Intervention
Viness Pillay The complete synthesis, optimization, purification, functionalization and evaluation of vertically aligned multiwalled carbon nanotubes (VA-MWCNTs) was reported for potential application in dexamethasone delivery to the ischemic brain tissue. The conditions for high yield were optimized and carbon nanotubes functionalized and PEGylated prior to dexamethasone loading. Morphological changes were confirmed by SEM and TEM. Addition of functional groups to MWCNTs was demonstrated by FTIR. Thermal stability reduced following MWCNTs functionalization as demonstrated in TGA. The presence of carbon at 2&th...
Source: Molecules - June 10, 2018 Category: Chemistry Authors: Patrick P. Komane Pradeep Kumar Thashree Marimuthu Lisa C. du Toit Pierre P. D. Kondiah Yahya E. Choonara Viness Pillay Tags: Article Source Type: research