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Endothelial Cell CD36 Reduces Atherosclerosis and Controls Systemic Metabolism
Front Cardiovasc Med. 2021 Nov 23;8:768481. doi: 10.3389/fcvm.2021.768481. eCollection 2021.ABSTRACTHigh-fat Western diets contribute to tissue dysregulation of fatty acid and glucose intake, resulting in obesity and insulin resistance and their sequelae, including atherosclerosis. New therapies are desperately needed to interrupt this epidemic. The significant idea driving this research is that the understudied regulation of fatty acid entry into tissues at the endothelial cell (EC) interface can provide novel therapeutic targets that will greatly modify health outcomes and advance health-related knowledge. Dysfunctional ...
Source: Atherosclerosis - December 10, 2021 Category: Cardiology Authors: Umar R Rekhi Mohamed Omar Maria Alexiou Cole Delyea Linnet Immaraj Shokrollah Elahi Maria Febbraio Source Type: research

Probiotics improve gut microbiota dysbiosis in obese mice fed a high-fat or high-sucrose diet
The prevalence of obesity has been dramatically increasing globally over decades [1]. Obesity is caused by a complex interaction of genetic and environmental factors, and is also suggested to be the result of a long-term imbalance between energy intake and expenditure [2]. Calorie-rich foods that are high in fat or carbohydrates combining with sedentary lifestyles are the most common factors underlying the global obesity epidemic [3]. High-fat diets (HFD) increase adipose tissue and induce metabolic and cardiovascular disorders (such as atherosclerosis, type 2 diabetes, stroke, and hypertension [4, 5]), especially in those...
Source: Nutrition - October 10, 2018 Category: Nutrition Authors: Cheng Kong, Renyuan Gao, Xuebing Yan, Linsheng Huang, Huanlong Qin Source Type: research

GSE72278 A novel lineage of adipose tissue regulatory T cells controls obesity and insulin resistance
Contributors : Emilie Stolarczyk ; Charlotte Bailey ; Natividad Garrido-Mesa ; Paul Lavender ; Richard Jenner ; Graham Lord ; Jane HowardSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe epidemic of obesity and its associated systemic metabolic complications continues to increase. Adipose tissue (AT)-associated T cells have been proposed to play an important role in the regulation of bodyweight and insulin sensitivity with a link to Th1 or Th2 lineage specification. A specific subset of regulatory T cells (TREGS) plays a critical and non-redundant role in controlling s...
Source: GEO: Gene Expression Omnibus - December 1, 2017 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research