• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Genes, Vol. 14, Pages 1171: Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis
Olga Y. Bushueva HSPA8 is involved in many stroke-associated cellular processes, playing a pivotal role in the protein quality control system. Here we report the results of the pilot study aimed at determining whether HSPA8 SNPs are linked to the risk of ischemic stroke (IS). DNA samples from 2139 Russians (888 IS patients and 1251 healthy controls) were genotyped for tagSNPs (rs1461496, rs10892958, and rs1136141) in the HSPA8 gene using probe-based PCR. SNP rs10892958 of HSPA8 was associated with an increased risk (risk allele G) of IS in smokers (OR = 1.37; 95% CI = 1.07–1.77; p = 0.01) and patients ...
Source: Genes - May 27, 2023 Category: Genetics & Stem Cells Authors: Ksenia A. Kobzeva Maria O. Soldatova Tatiana A. Stetskaya Vladislav O. Soldatov Alexey V. Deykin Maxim B. Freidin Marina A. Bykanova Mikhail I. Churnosov Alexey V. Polonikov Olga Y. Bushueva Tags: Article Source Type: research

Investigating the in vivo effect of Tribulus terrestris extract in MCAO rats by using LC-MS-based metabolomics combined with the molecular docking
This study aimed to investigate the protective effect of TT extract, named TT15, on middle cerebral artery occlusion (MCAO) rats by metabolomics and molecular docking, and find the targets of action and the material basis of TT15 against IS. The results of the infarct volume and neurological defect scores confirmed the efficacy of TT15. The serum metabolomics analysis using LC-MS revealed that Model group animals experienced a variety of metabolic disturbances when compared to the Sham group. TT15 can restore the MCAO-induced serum metabolite changes by modulating multiple metabolic pathways. Six enzymes were highlighted b...
Source: Biomedical Chromatography : BMC - March 8, 2023 Category: Biomedical Science Authors: Xingxing Li Wenjun Guo Liang Zhao Dandan Xu Xiaohang Xu Yuqing Han Chengyan Wang Yingzi Jiang Yang Wang Yajuan Xu Source Type: research

Bioactive Compounds (BACs): A Novel Approach to Treat and Prevent Cardiovascular Diseases
Curr Probl Cardiol. 2023 Feb 23:101664. doi: 10.1016/j.cpcardiol.2023.101664. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are one of the leading disorders of serious death and cause huge economic loss to patients and society. It is estimated that about 18 million people have a high death ratio due to the incidence of CVDs such as (stroke, coronary heart disease, and non-ischemic heart failure). Bioactive compounds (BACs) are healthy nutritional ingredients providing beneficial effects and nutritional value to the human body. Epidemiological studies strongly shed light on several bioactive compounds that ar...
Source: Atherosclerosis - February 25, 2023 Category: Cardiology Authors: Syed Riaz Ud Din Sumbul Saeed Shahid Ullah Khan Mintao Zhong Source Type: research

Stroke risk with vegetarian, low-animal and high-animal diets: A systematic review and meta-analysis
CONCLUSIONS: Stroke risk is lower with more use of a vegetarian or low-animal diet but relatively higher with more use of a high-animal diet.PMID:36173214 | DOI:10.6133/apjcn.202209_31(3).0010
Source: Asia Pacific Journal of Clinical Nutrition - September 29, 2022 Category: Nutrition Authors: Yang Liu Linlin Zhu Dong Li Liankun Wang Han Tang Chunyuan Zhang Source Type: research

Pages: 1  2  3  4  5  6