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Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF- κB signaling pathway
CONCLUSIONS: These findings indicate that ICT plays roles in inhibiting the inflammatory response and achieving neuroprotection by regulating GPER-ERK-NF-κB signaling and then inhibiting microglial activation and M1 polarization while promoting M2 polarization, which provides a new therapeutic for against cerebral ischemic stroke.PMID:36447154 | DOI:10.1186/s10020-022-00573-7
Source: Molecular Medicine - November 29, 2022 Category: Molecular Biology Authors: Zining Yu Guangjun Su Limei Zhang Gaigai Liu Yonggang Zhou Shicai Fang Qian Zhang Tianyun Wang Cheng Huang Zhihua Huang Liangdong Li Source Type: research

PAC proton-activated chloride channel contributes to acid-induced cell death in primary rat cortical neurons.
Authors: Osei-Owusu J, Yang J, Del Carmen Vitery M, Tian M, Qiu Z Abstract Severe local acidosis causes tissue damage and pain, and is associated with many diseases, including cerebral and cardiac ischemia, cancer, infection, and inflammation. However, the molecular mechanisms of the cellular response to extracellular acidic environment are not fully understood. We recently identified a novel and evolutionarily conserved membrane protein, PAC (also known as PACC1 or TMEM206), encoding the proton-activated chloride (Cl-) channel, whose activity is widely observed in human cell lines. We demonstrated that genetic del...
Source: Channels - February 26, 2020 Category: Molecular Biology Tags: Channels (Austin) Source Type: research