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A Single-Center Clinical Study to Evaluate Shenxiong Glucose Injection Combined with Edaravone in the Treatment of Acute Large-Area Cerebral Infarction
CONCLUSIONS: In addition to the routine basic treatment of acute large-area cerebral infarction, the addition of Shenxiong glucose injection combined with edaravone injection can improve platelet aggregation and reduce inflammation by affecting P-selectin, D-dimer, and FIB. This treatment approach promotes the recovery of nerve defect function without obvious adverse reactions in patients with acute large-area cerebral infarction.PMID:34307676 | PMC:PMC8263277 | DOI:10.1155/2021/9935752
Source: Biomed Res - July 26, 2021 Category: Research Authors: Zongqin Li Xiaoxia Rong Jun Luo Tao Zeng Pan Huang Xuejie Xu Source Type: research

Aggravation of Cerebral Ischemia/Reperfusion Injury by Peroxisome Proliferator-Activated Receptor-Gamma Deficiency via Endoplasmic Reticulum Stress.
CONCLUSIONS This research proved that PPAR-γ protected the brain from cerebral I/R injury by repressing ER stress and indicated that PPAR-γ is a potential target in the treatment of ischemia. PMID: 31588926 [PubMed - in process]
Source: Medical Science Monitor - October 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice
SummaryIschemic stroke leads to high potentiality of mortality and disability. The current treatment for ischemic stroke is mainly focused on intravenous thrombolytic therapy. However, ischemia/ reperfusion induces neuronal damage, which significantly influences the outcome of patients with ischemic stroke, and the exact mechanism implicated in ischemia/reperfusion injury remains unclear, although evidence shows that oxidative stress is likely to be involved. Betulinic acid is mainly known for its anti-tumor and anti-inflammatory activities. Our previous study showed that betulinic acid could decrease the reactive oxygen s...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 1, 2017 Category: Research Source Type: research