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Ketamine improves neuronal recovery following spreading depolarization in peri ‐infarct tissues
We examined spreading depolarization (SD) waves in a mouse stroke model. SDs were initiated by focal potassium chloride application and propagated through a region of graded perfusion deficit created by distal middle cerebral artery (dMCA) occlusion. Longer lasting depolarizations (DC shifts measured from local field potential (LFP) electrodes) and neuronal Ca2+ transients (epifluorescence GCaMP imaging) occurred at locations with larger perfusion deficits (proximal to occlusion), as compared with remote recording sites (laser speckle contrast imaging (LSCI) of cerebral perfusion). Ketamine, at concentrations that did not ...
Source: Journal of Neurochemistry - August 19, 2023 Category: Neuroscience Authors: Katelyn M. Reinhart, Russell A. Morton, K. C. Brennan, Andrew P. Carlson, C. William Shuttleworth Tags: ORIGINAL ARTICLE Source Type: research

Rapid, label-free detection of cerebral ischemia in rats using hyperspectral imaging
ConclusionsThese results demonstrate the practical utility of HSI for the real-time detection of cerebral ischemia in rats. By providing rapid assessment of brain tissue perfusion, HSI may help doctors recognize ischemic regions quickly and precisely during surgery as well as have great utility in the experimental process.
Source: Journal of Neuroscience Methods - October 19, 2019 Category: Neuroscience Source Type: research