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MiR-130a exerts neuroprotective effects against ischemic stroke through PTEN/PI3K/AKT pathway.
CONCLUSIONS: Our data demonstrated that miR-130a prevented cerebral I/R damage by mediating the PTEN/PI3K/AKT axis. These preliminarily findings furthered our understanding of this mechanism and identified new potential therapeutic targets for ischemic stroke. PMID: 31226635 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 17, 2019 Category: Drugs & Pharmacology Authors: Zheng T, Shi Y, Zhang J, Peng J, Zhang X, Chen K, Chen Y, Liu L Tags: Biomed Pharmacother Source Type: research

Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury.
In this study, we investigated the effects of IL-11 on cerebral ischemia-reperfusion injury in a model of focal cerebral ischemia. METHODS: Mice were randomly divided into five groups the vehicle group, the middle cerebral artery occlusion (MCAO) group, the MCAO plus adenosine monophosphate-activated protein kinase (AMPK) inhibitor compound C group, the MCAO plus IL-11 treatment group, and the MCAO plus IL-11 treatment and compound C group. Focal cerebral ischemia was induced by occluding the left middle cerebral artery, and reperfusion was achieved by withdrawing the suture 2 h after ischemia. The protein expressio...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 12, 2019 Category: Drugs & Pharmacology Authors: Zhang B, Zhang HX, Shi ST, Bai YL, Zhe X, Zhang SJ, Li YJ Tags: Biomed Pharmacother Source Type: research