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Uncoupling Protein 2 as a pathogenic determinant and therapeutic target in cardiovascular and metabolic diseases
Curr Neuropharmacol. 2021 Apr 20. doi: 10.2174/1570159X19666210421094204. Online ahead of print.ABSTRACTUncoupling protein 2 (UCP2) is a mitochondrial protein that acts as an anion carrier. It is involved in the regulation of several processes including mitochondrial membrane potential, generation of reactive oxygen species within the inner mitochondrial membrane and calcium homeostasis. UCP2 expression can be regulated at different levels: genetic (gene variants), transcriptional [by peroxisome proliferator-activated receptors (PPARs) and microRNAs], and post-translational. Experimental evidence indicates that activation ...
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: Rosita Stanzione Maurizio Forte Maria Cotugno Franca Bianchi Simona Marchitti Carla Letizia Busceti Francesco Fornai Speranza Rubattu Source Type: research

Better Treatments To Reverse Congestive Heart Failure
Take it easy… stay in bed. That’s what most doctors tell patients with congestive heart failure. I can’t think of worse advice. What’s Congestive Heart Failure? Congestive heart failure (CHF) means your heart can’t pump enough blood for your body’s needs. Blood builds up behind the heart. Fluids accumulate in the lungs and make you weak, tired and short of breath. Less blood flowing to your brain makes you dizzy and confused. Vital organs like your lungs, brain and kidneys begin to shut down. What Happens When You Have CHF? A heart with CHF is severely deconditioned. When your heart pu...
Source: Al Sears, MD Natural Remedies - June 13, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Health Source Type: news

Life is Simple: Eat, Sleep, Swim, Repeat
A glass of crisp white and a rocket salad. And the potato mash, please. I haven't met a potato I didn't like. Famished each afternoon of my recent magical mermaid holiday, I sat down with wet salty hair, ordered and devoured. Swimming burns so much energy. I watched the beach full of swimmers and surfers. This is one wave of heaven, for me I thought, as I scribed notes on my pile of 4 X 6 cards. Noting and documenting my time in Oz waters, while watching it. I am lifted up this day. I met Mark and I get it. The magnificent pull of the sea. The perfect simple elegant solution to all that troubles us. Move in the water. Per ...
Source: Healthy Living - The Huffington Post - May 28, 2016 Category: Consumer Health News Source Type: news

Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis
Conclusion: B. oleracea administration prevented renal damage in salt-loaded SHRSP, independently from SBP, with parallel stimulation of AMPK/SIRT1/PGC1α/PPARα/UCP2 axis. Stimulation of the latter mechanism may provide relevant renal protective effect and play a therapeutic role in target organ damage progression in hypertension.
Source: Journal of Hypertension - June 5, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research