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Antithrombotic activity of flavonoids and polyphenols rich plant species.
Abstract Cardiovascular diseases represent one of the most notable health problems of the modern civilization. Stroke and heart attack often lead to lethal outcome; essential problem underneath being thrombus formation. Prophylactic approaches include acetylsalicylic acid and clopidogrel therapy on the level of primary hemostasis, i.e., primary clot formation. In the last five years, in the USA, health care expenses related to cardiovascular diseases have increased 50 %, to over 350 billion dollars. Thus, application of plant species and medicinal plants rich in polyphenols in prevention of thrombus formation are ...
Source: Acta Pharmaceutica - October 23, 2019 Category: Drugs & Pharmacology Authors: Bojić M, Maleš Ž, Antolić A, Babić I, Tomičić M Tags: Acta Pharm Source Type: research

Improvement of memory and neurological deficit with Ocimum basilicum L. extract after ischemia reperfusion induced cerebral injury in mice
AbstractOxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention.Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory has reported protective effects of pre-treatment withO. basilicum in experimental stroke, but its curative (post-treatment) effects in ischemic stroke have not been documented. Hence, the present study was aimed to evaluate the effect ofO. basilicum leaf extract (OBLE) on functional outcomes following cer...
Source: Metabolic Brain Disease - March 15, 2018 Category: Neurology Source Type: research

Evaluating the anticoagulant effect of medicinal plants in vitro by cheminformatics methods
Conclusion In this study, the anticoagulant effect was identified as a significant property of five medicinal plants. These plants can be regarded as likely candidates for prevention and treatment of complications in individuals with high risk of stroke or ischemia. Also, we suggest that these plants should be cautiously consumed with anticoagulant drugs (e.g. heparin) due to a risk of hemorrhage and increase in the effect of anticoagulant drugs.
Source: Journal of Herbal Medicine - May 17, 2016 Category: Complementary Medicine Source Type: research