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In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure
In conclusion, cardiac-specific AC4 gene expression protects against Klotho deficiency-induced heart failure through increasing cardiomyocytic cAMP levels, which alleviates cAMP-dependent mitochondrial dysfunction, superoxide accumulation and apoptotic cell death. AC4 regulates superoxide levels via the cAMP-PKA pathway. AC4 could be a potential therapeutic target for heart failure associated with Klotho deficiency. BACKGROUND: Heart failure is the major cause of mortality in patients with chronic kidney disease (CKD). A decrease in Klotho levels is linked to CKD. TRANSLATIONAL SIGNIFICANCE: We expect that treatment with K...
Source: Translational Research : the journal of laboratory and clinical medicine - February 3, 2022 Category: Laboratory Medicine Authors: Kai Chen Shirley Wang Zhongjie Sun Source Type: research

Hypertension Management in Primary Care in the Capital Area of Iceland
CONCLUSION: As has recently been shown in epidemiologic studies hypertension in Iceland is both underdiagnosed and undertreated although the country ranks high on both counts in international comparison. Furthermore, the fact that under half of hypertensive patients in general practice in the capital area reach the targeted treatment goals, cannot be considered an acceptable. Thus, it is of immense importance to improve both the diagnosis and the treatment of HT.PMID:35103619 | DOI:10.17992/lbl.2022.02.675
Source: Atherosclerosis - February 1, 2022 Category: Cardiology Authors: Stefan Julius Adalsteinsson Jon Steinar Jonsson Hannes Hrafnkelsson Gudmundur Thorgeirsson Emil Larus Sigurdsson Source Type: research

Calcium channel blockers versus other classes of drugs for hypertension
CONCLUSIONS: For the treatment of hypertension, there is moderate certainty evidence that diuretics reduce major cardiovascular events and congestive heart failure more than CCBs. There is low to moderate certainty evidence that CCBs probably reduce major cardiovascular events more than beta-blockers. There is low to moderate certainty evidence that CCBs reduced stroke when compared to angiotensin-converting enzyme (ACE) inhibitors and reduced myocardial infarction when compared to angiotensin receptor blockers (ARBs), but increased congestive heart failure when compared to ACE inhibitors and ARBs. Many of the differences ...
Source: Cochrane Database of Systematic Reviews - January 9, 2022 Category: General Medicine Authors: Jiaying Zhu Ning Chen Muke Zhou Jian Guo Cairong Zhu Jie Zhou Mengmeng Ma Li He Source Type: research

Current prescription status of antihypertensive drugs in Chinese patients with hypertension: analysis by type of comorbidities
Clin Exp Hypertens. 2022 Jan 3:1-9. doi: 10.1080/10641963.2021.2022688. Online ahead of print.ABSTRACTIn 2020, the National Center for Cardiovascular Diseases with National Committee on Hypertension Management in Primary Health Care in China issued revised national clinical practice guidelines on the management of hypertension in primary health care based on the 2018 Chinese guidelines for the management of hypertension. To evaluate adherence to the guidelines, this retrospective study assessed the real-world status of antihypertensive drug prescribing for Chinese patients with hypertension, classified by comorbidity: coro...
Source: Clinical and Experimental Hypertension - January 3, 2022 Category: Cardiology Authors: Renren Yang Jia Tang Yunping Zhuo Ming Kuang Hongying Liu Source Type: research

Utility of S100A12 as an Early Biomarker in Patients With ST-Segment Elevation Myocardial Infarction
Conclusions and Relevance: S100A12 rapidly identified patients with STEMI, more accurately than other cardiac biomarkers, especially within the first 2 h after symptom onset. The peak plasma S100A12 level was a strong predictor of 1-year prognosis after STEMI.PMID:34977174 | PMC:PMC8718434 | DOI:10.3389/fcvm.2021.747511
Source: Atherosclerosis - January 3, 2022 Category: Cardiology Authors: Xiaolin Zhang Minghui Cheng Naijing Gao Yi Li Chenghui Yan Xiaoxiang Tian Dan Liu Miaohan Qiu Xiaozeng Wang Bo Luan Jie Deng Shouli Wang Hongyan Tian Geng Wang Xinliang Ma Gregg W Stone Yaling Han Source Type: research

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