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Fighting brain damage from stroke using substance naturally found in humans
A molecular substance that occurs naturally in humans and rats was found to "substantially reduce" brain damage after an acute stroke and contribute to a better recovery, according to a newly released animal study by researchers at Henry Ford Hospital.The study, published online before print in Stroke, the journal of the American Heart Association, was the first ever to show that the peptide AcSDKP provides neurological protection when administered one to four hours after the onset of an ischemic stroke.
Source: Health News from Medical News Today - March 14, 2014 Category: Consumer Health News Tags: Stroke Source Type: news

Massive Interventricular Septal Aneurysm and Stroke in a Healthy Young Patient: Guilt by Association?
We describe here the case of an otherwise healthy, 41-year-old man who presented to the hospital with acute-onset confusion and left-sided body weakness attributed to a right middle cerebral artery ischemic stroke. He experienced a nearly complete resolution of deficits following systemic thrombolytic therapy. After an extensive workup, the presumed mechanism of stroke was a thromboembolus that originated in a massive aneurysm of the patient's membranous interventricular septum. Due to a perceived risk of surgical morbidity, the patient was managed conservatively with anticoagulation. He denied further events and reported ...
Source: Journal of Stroke and Cerebrovascular Diseases - June 10, 2013 Category: Neurology Authors: John C. Stendahl, Amatul S. Hasan, Mengistu A. Simegn Tags: Case Reports Source Type: research

Deleterious Effect of Smoking on Ischemic Stroke Outcomes: Implications for the Role of Chronic Inflammation on Atherosclerotic Plaque Pathogenesis
I have read, with great interest, a recently published article in the Journal of Stroke and Cerebrovascular Diseases by Edjoc et al titled “The prognostic effect of cigarette smoking on stroke severity, disability, length of stay in hospital, and mortality in a cohort with cerebrovascular disease.” The authors performed a retrospective analysis of the Registry of the Canadian Stroke Network to identify the effect of smoking on cerebrovascular disease outcomes. More than 20,000 patients from the registry, spanning an approximately 5-year time interval, were included in the study. Multivariate logistic regression analys...
Source: Journal of Stroke and Cerebrovascular Diseases - March 1, 2014 Category: Neurology Authors: Dale Ding Tags: Letters to the Editor Source Type: research

Hospitalized Hemorrhagic Stroke Patients with Renal Insufficiency: Clinical Characteristics, Care Patterns, and Outcomes
Background: There is a paucity of information on clinical characteristics, care patterns, and clinical outcomes for hospitalized intracerebral hemorrhage (ICH) patients with chronic kidney disease (CKD). We assessed characteristics, care processes, and in-hospital outcome among ICH patients with CKD in the Get With the Guidelines–Stroke (GWTG-Stroke) program.Methods: We analyzed 113,059 ICH patients hospitalized at 1472 US centers participating in the GWTG-Stroke program between January 2009 and December 2012. In-hospital mortality and use of 2 predefined ICH performance measures were examined based on glomerular filtrat...
Source: Journal of Stroke and Cerebrovascular Diseases - August 25, 2014 Category: Neurology Authors: Bruce Ovbiagele, Lee H. Schwamm, Eric E. Smith, Maria V. Grau-Sepulveda, Jeffrey L. Saver, Deepak L. Bhatt, Adrian F. Hernandez, Eric D. Peterson, Gregg C. Fonarow Tags: Original Articles Source Type: research

Acute Stroke Reperfusion Therapy Trends in the Expanded Treatment Window Era
Background: The American Heart Association/American Stroke Association (AHA/ASA) recommended an expansion of the time window for acute ischemic stroke (AIS) reperfusion with intravenous (IV) recombinant tissue plasminogen activator (rt-PA) from 3 to 4.5 hours after symptom onset. We examine rates of IV and intra-arterial (IA) reperfusion before and after the recommendations to track guideline adoption in community practice.Methods: Patients with AIS in the Paul Coverdell National Acute Stroke Registry spanning years 2007-2012 were identified. Trends in rates of IV rt-PA versus IA therapy were examined. Outcomes included s...
Source: Journal of Stroke and Cerebrovascular Diseases - August 25, 2014 Category: Neurology Authors: Ganesh Asaithambi, Xin Tong, Mary G. George, Albert W. Tsai, James M. Peacock, Russell V. Luepker, Kamakshi Lakshminarayan Tags: Original Articles Source Type: research

Cost Burden of Stroke Mimics and Transient Ischemic Attack after Intravenous Tissue Plasminogen Activator Treatment
Treatment decisions for patients with acute stroke symptoms are based on pertinent history, neurologic examination, laboratory studies, and head computed tomography. In this setting, patients with stroke mimic (SM) may mistakenly receive intravenous tissue plasminogen activator (IV-rtPA). The goal of this study was to investigate the excess direct/indirect hospital costs among patients who received IV-rtPA when final diagnosis was not ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - February 23, 2015 Category: Neurology Authors: Nitin Goyal, Shailesh Male, Ameer Al Wafai, Sushma Bellamkonda, Ramin Zand Source Type: research

The Hospital Costs of Stroke Patients in Chinese Island Populations: An 11-Year Tendency Analysis
The impact of stroke is devastating the life of patients, families, and even the communities. The cost of treatment; however, has the tendency of increasing nowadays, which has brought a heavy burden to patients and their families. Our study aims to collect the data of the hospital cost among stroke patients in Chinese island populations over the past decade and provide the scientific improvement for stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - March 24, 2015 Category: Neurology Authors: Xiaomei Wu, Safeng Zou, Bo Zhu, Jingpu Shi Source Type: research

Hospital Differences in Motor Activity Early after Stroke. A Comparison of 11 Norwegian Stroke Units
Activity levels in patients early after stroke vary across the world. The primary aim of this study was to assess the variation in motor activity in patients admitted to multiple Norwegian stroke units and to identify factors which explained the variation between hospitals.
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2015 Category: Neurology Authors: Anne Hokstad, Bent Indredavik, Julie Bernhardt, Hege Ihle-Hansen, Øyvind Salvesen, Yngve Müller Seljeseth, Stephan Schüler, Torgeir Engstad, Torunn Askim Source Type: research

A SMARTer approach to stroke care
Time is critical when it comes to stroke: early treatment is associated with better outcomes. According to the Screening with MRI for Accurate and Rapid stroke Treatment (SMART) study, small changes in quality improvement procedures enabled clinicians to use MRI scans to diagnose stroke patients before giving acute treatment, within 60 minutes of hospital arrival. MRI scans provide detailed images but take longer to complete than CT scans, which are commonly used in most centers.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - May 13, 2015 Category: Neurology Source Type: news

Hospital Differences in Motor Activity Early after Stroke: A Comparison of 11 Norwegian Stroke Units
Activity levels in patients early after stroke vary across the world. The primary aim of this study was to assess the variation in motor activity in patients admitted to multiple Norwegian stroke units and to identify factors which explained the variation between hospitals.
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2015 Category: Neurology Authors: Anne Hokstad, Bent Indredavik, Julie Bernhardt, Hege Ihle-Hansen, Øyvind Salvesen, Yngve Müller Seljeseth, Stephan Schüler, Torgeir Engstad, Torunn Askim Tags: Original Article Source Type: research

Effect of β-Adrenergic Antagonists on In-Hospital Mortality after Ischemic Stroke
Ischemic stroke accounts for 85%-90% of all strokes and currently has very limited therapeutic options. Recent studies of β-adrenergic antagonists suggest they may have neuroprotective effects that lead to improved functional outcomes in rodent models of ischemic stroke; however, there are limited data in patients. We aimed to determine whether there was an improvement in mortality rates among patients who were taking β-blockers during the acute phase of their ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2015 Category: Neurology Authors: Christopher Phelan, Vivek Alaigh, Gil Fortunato, Ilene Staff, Lauren Sansing Source Type: research

The CHADS2 Components Are Associated with Stroke-Related In-hospital Mortality in Patients with Atrial Fibrillation
The CHADS2 score predicts stroke risk in patients with atrial fibrillation. Although strokes caused by atrial fibrillation carry the highest mortality when compared with other etiologies, it is not known whether the CHADS2 score predicts stroke-related mortality in patients with atrial fibrillation. We hypothesized that higher CHADS2 scores would be associated with higher stroke-related in-hospital mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2015 Category: Neurology Authors: Shadi Yaghi, Ayesha Sherzai, Markeith Pilot, Dean Sherzai, Mitchell S.V. Elkind Source Type: research

Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation Combined with Intensive Speech Therapy on Cerebral Blood Flow in Post-Stroke Aphasia
Abstract We provided an intervention to chronic post-stroke aphasic patients using low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) guided by a functional magnetic resonance imaging (fMRI) evaluation of language laterality, combined with intensive speech therapy (ST). We performed a single photon emission-computed tomography (SPECT) scan pre- and post-intervention and investigated the relationship between cerebral blood flow (CBF) and language function. Fifty right-handed chronic post-stroke aphasic patients were enrolled in the study. During their 11-day hospital admission, the patients receiv...
Source: Translational Stroke Research - August 7, 2015 Category: Neurology Source Type: research

Hemorrhagic stroke following use of the synthetic marijuana "spice"
The association between the street drug spice (K-2 or herbal incense), a synthetic marijuana, and intracranial hemorrhage (ICH) has not yet been described, but it has with acute ischemic stroke (AIS),1 seizure, and myocardial infarction.2 Two young patients (31 and 25 years old) independently presented to our hospital with subarachnoid hemorrhage (SAH) after spice inhalation. The first also had 2 large intraparenchymal hemorrhages (IPH); the other also had AIS. Both were previously healthy without hypertension, coagulopathy, bleeding diathesis, thrombocytopenia, intracranial aneurysm, arteriovenous malformation, connective...
Source: Neurology - September 28, 2015 Category: Neurology Authors: Rose, D. Z., Guerrero, W. R., Mokin, M. V., Gooch, C. L., Bozeman, A. C., Pearson, J. M., Burgin, W. S. Tags: Stroke in young adults, Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Other toxicology, Intracerebral hemorrhage CLINICAL/SCIENTIFIC NOTES Source Type: research

Risk of Malnutrition Is an Independent Predictor of Mortality, Length of Hospital Stay, and Hospitalization Costs in Stroke Patients
This study aimed to determine the ability of the Malnutrition Universal Screening Tool (MUST) to predict poor outcomes in stroke patients, including mortality, cumulative length of hospital stay (LOS), and hospitalization costs.
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2016 Category: Neurology Authors: Filomena Gomes, Peter W. Emery, C. Elizabeth Weekes Source Type: research