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PCSK9 inhibition in patients with acute stroke and symptomatic intracranial atherosclerosis: protocol for a prospective, randomised, open-label, blinded end-point trial with vessel-wall MR imaging
BMJ Open. 2022 Apr 29;12(4):e060068. doi: 10.1136/bmjopen-2021-060068.ABSTRACTINTRODUCTION: Dual antiplatelet therapy and high-intensity statins are the mainstay treatment in patients with acute stage, symptomatic intracranial atherosclerotic stenosis (ICAS). Alirocumab is a monoclonal antibody that can inhibit proprotein convertase subtilisin-kexin type 9 and effectively lower low-density lipoprotein cholesterol levels with less side effects than statins. We hypothesise that alirocumab treatment in addition to statin therapy could stabilise intracranial plaque and reduce arterial stenosis.METHODS AND ANALYSIS: In this pro...
Source: Atherosclerosis - April 29, 2022 Category: Cardiology Authors: Yen-Chu Huang Chia-Hao Chang Yuan-Hsiung Tsai Hsu-Huei Weng Leng-Chieh Lin Jiann-Der Lee Source Type: research

IJERPH, Vol. 19, Pages 2278: The Impacts of COVID-19 on Healthcare Quality in Tertiary Medical Centers & mdash;A Retrospective Study on Data from Taiwan Clinical Performance Indicators System
IJERPH, Vol. 19, Pages 2278: The Impacts of COVID-19 on Healthcare Quality in Tertiary Medical Centers—A Retrospective Study on Data from Taiwan Clinical Performance Indicators System International Journal of Environmental Research and Public Health doi: 10.3390/ijerph19042278 Authors: Shih-An Liu Chieh-Liang Wu I-Ju Chou Pa-Chun Wang Chia-Ling Hsu Chia-Pei Chen To date, COVID-19 is by far the most impactful contagious disease of the 21st century and it has had a devastating effect on public health in countries around the globe. Elective medical services have declined markedly since the outbreak...
Source: International Journal of Environmental Research and Public Health - February 17, 2022 Category: Environmental Health Authors: Shih-An Liu Chieh-Liang Wu I-Ju Chou Pa-Chun Wang Chia-Ling Hsu Chia-Pei Chen Tags: Article Source Type: research

Association of traditional complementary and alternate medicine usage with quality of life of diabetic patients in a Malaysian tertiary hospital
This study aims to design to assess the traditional, complementary and alternate medicine (TCAM) usage and its association with the quality of life (QOL) of Type 2 diabetic patients in a tertiary hospital (Hospital Universiti Sains Malaysia) in Malaysia. A total of 300 respondents included in this study were divided into the following two major categories: TCAM (34.33% of respondents) and non-TCAM users (65.67% of the respondents), respectively. The mean ages of the respondents were 59.3 ± 10.2 for the TCAM users and 57.7 ± 12.0 for the non-TCAM users. A greater percentage of non-TCAM users reported poor co...
Source: Nutrition and Food Science - June 26, 2021 Category: Nutrition Authors: Chinedum Ogbonnaya Eleazu Aniza Abd Aziz Tay Chuu Suen Lam Chun-Hau Chin Elynn Chia Yi Hen Ivan Ho Khor Ee Lau Li Ren Sabarisah Hashim Mahaneem Mohamed Source Type: research

IJERPH, Vol. 17, Pages 618: Risk Factors Associated with Outcomes of Recombinant Tissue Plasminogen Activator Therapy in Patients with Acute Ischemic Stroke
eng Tsong-Hai Lee Ischemic stroke is the most common type of stroke, and early interventional treatment is associated with favorable outcomes. In the guidelines, thrombolytic therapy using recombinant tissue-type plasminogen activator (rt-PA) is recommended for eligible patients with acute ischemic stroke. However, the risk of hemorrhagic complications limits the use of rt-PA, and the risk factors for poor treatment outcomes need to be identified. To identify the risk factors associated with in-hospital poor outcomes in patients treated with rt-PA, we analyzed the electronic medical records of patients who were diagn...
Source: International Journal of Environmental Research and Public Health - January 17, 2020 Category: Environmental Health Authors: Yi-Ju Tseng Ru-Fang Hu Shin-Tyng Lee Yu-Li Lin Chien-Lung Hsu Shih-Wei Lin Chia-Wei Liou Jiann-Der Lee Tsung-I Peng Tsong-Hai Lee Tags: Article Source Type: research

The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans
This study aims to determine the prevalence of hyperuricemia and its association with the outcome of patients with acute ischemic stroke in a tertiary care hospital.
Source: Journal of Stroke and Cerebrovascular Diseases - November 15, 2017 Category: Neurology Authors: Yacouba Njankouo Mapoure, Chia Mark Ayeah, Hamadou Ba, Romuald Hentchoya, Henry Namme Luma Source Type: research

Nuts, seeds, beans are good steps toward a plant-based diet
A plant-based diet rich in fruits, vegetables, whole grains, and healthy plant oils can help men stay healthy and ward off heart disease, stroke, diabetes, cancer, and other chronic conditions. Adding fresh fruits and vegetables is a no-brainer for adopting a plant-based diet, but don't neglect nuts and seeds along with beans and other legumes, recommends the December 2014 Harvard Men's Health Watch. Choosing the right portions is important, too. Nuts and seeds are rich in vegetable oils, which pack nine calories per gram. That means eating too many nuts and seeds in a day can deliver an overload of calories. But it doesn'...
Source: New Harvard Health Information - November 24, 2014 Category: Consumer Health News Source Type: news

Effects of Noxious Versus Innocuous Thermal Stimulation on Lower Extremity Motor Recovery 3 Months After Stroke
Abstract: Objective: To examine the effects of thermal stimulation (TS) on the lower extremity (LE) movement and function in patients with stroke.Design: A double-blinded randomized controlled trial.Setting: A university hospital.Participants: Patients (N=34) at least 3 months after stroke were randomly assigned into the experimental and the control groups.Interventions: In addition to regular rehabilitation, the experimental group received a 30-minute noxious TS protocol (heat pain 46–47°C/cold pain 2–3°C) 3days/wk for 8 weeks, and the control group received a 30-minute innocuous TS protocol (heat 40–41°C/cold 23...
Source: Archives of Physical Medicine and Rehabilitation - November 26, 2012 Category: Rehabilitation Authors: Hsin-Wen Hsu, Chia-Ling Lee, Miao-Ju Hsu, Hung-Chia Wu, Roxane Lin, Ching-Lin Hsieh, Jau-Hong Lin Tags: Original Articles Source Type: research