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The role of hippocampal pathology in post-stroke cognitive impairment
Background Cognitive impairment is common following cerebrovascular disease. Recently it has been associated with hippocampal ultra-structural damage in stroke survivors. We aim to study the long-term cognitive profile of patients after ischaemic stroke and characterise the cognitive behaviours associated with any dynamic changes in the structure, function and metabolism of the hippocampi, using multimodal MRI at 3Tesla. Methods We are conducting a dual-centre study to investigate the predictive value of diagnostic MRI and resting-state fMRI based on observing natural history of cognitive function following stroke (at bas...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Hosseini, A. A., Ispoglou, S., Hayton, T., Evans, R., Wilson, M., Sawlani, V., Rotshtein, P., Auer, D. P. Tags: Stroke, Memory disorders (psychiatry), Radiology, Radiology (diagnostics) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Continuing or Temporarily Stopping Prestroke Antihypertensive Medication in Acute StrokeNovelty and Significance Stroke
Over 50% of patients are already taking blood pressure–lowering therapy on hospital admission for acute stroke. An individual patient data meta-analysis from randomized controlled trials was undertaken to determine the effect of continuation versus temporarily stopping preexisting antihypertensive medication in acute stroke. Key databases were searched for trials against the following inclusion criteria: randomized design; stroke onset ≤48 hours; investigating the effect of continuation versus stopping prestroke antihypertensive medication; and follow-up of ≥2 weeks. Two randomized controlled trials were identified a...
Source: Hypertension - April 12, 2017 Category: Cardiology Authors: Lisa J. Woodhouse, Lisa Manning, John F. Potter, Eivind Berge, Nikola Sprigg, Joanna Wardlaw, Kennedy R. Lees, Philip M. Bath, Thompson G. Robinson Tags: High Blood Pressure, Hypertension, Intracranial Hemorrhage, Ischemic Stroke Original Articles Source Type: research

Cerebral collateral circulation in experimental ischemic stroke
AbstractCerebral collateral circulation is a subsidiary vascular network, which is dynamically recruited after arterial occlusion, and represents a powerful determinant of ischemic stroke outcome. Although several methods may be used for assessing cerebral collaterals in the acute phase of ischemic stroke in humans and rodents, they are generally underutilized. Experimental stroke models may play a unique role in understanding the adaptive response of cerebral collaterals during ischemia and their potential for therapeutic modulation. The systematic assessment of collateral perfusion in experimental stroke models may be us...
Source: Experimental and Translational Stroke Medicine - March 1, 2016 Category: Neurology Source Type: research

Self-perceived and Actual Risk of Further Stroke in Patients with Recurrent Stroke or Recurrent Transient Ischemic Attack in Thailand
Background: The correct perception in patients of their future risk of recurrent stroke may lead to changes in behavior and to successful secondary prevention of stroke. The primary aim was to compare patients ’ perceived risk with the actual risk of further stroke. Methods: This cross-sectional study was carried out in 2 tertiary hospitals in northeast Thailand. Self-perceived risk of further stroke was assessed by validated questionnaire and categorized as low, medium, or high. Actual risk was calcula ted using Stroke Prognosis Instrument II which classified patients into 3 risk groups: low, medium, and high.
Source: Journal of Stroke and Cerebrovascular Diseases - November 29, 2018 Category: Neurology Authors: Jittima Saengsuwan, Pathitta Suangpho Source Type: research

Warm Front Passage on the Previous Day Increased Ischemic Stroke Events
Background and Purpose: The influence of a weather front passage is rarely evaluated on stroke events. We hypothesized that a weather front passage on the stroke onset day or during the previous days may play an important role in the incidence of stroke. Methods: A multicenter retrospective study was conducted to evaluate the frequency of stroke events and their interaction with weather front passages. Consecutive acute stroke patients (n  = 3935, 73.5 ± 12.4 years, 1610 females) who were admitted to 7 stroke hospitals in 3 cities from January 2012 to December 2013 were enrolled in this study.
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2019 Category: Neurology Authors: Ryo Shimomura, Naohisa Hosomi, Miwako Tsunematsu, Tomoya Mukai, Yoshimasa Sueda, Yutaka Shimoe, Tomohiko Ohshita, Tsuyoshi Torii, Tomohisa Nezu, Shiro Aoki, Masayuki Kakehashi, Masayasu Matsumoto, Hirofumi Maruyama, Hiroshima ‘Emergency and Weather’ S Source Type: research

Lateralization of Insular Ischemic Stroke is Not Associated With Any Stroke Clinical Outcomes: The Athens Stroke Registry
Background: Controversial evidence suggests that right insular stroke may be associated with worse outcomes compared to the left insular ischemic lesion. Objectives: We investigated whether lateralization of insular stroke is associated with early and late outcome in terms of in-hospital complications, stroke recurrence, cardiovascular events, and death. Methods: Data were prospectively collected from the Athens Stroke Registry. Insular cortex involvement was identified based on brain CT scans or MRI images.
Source: Journal of Stroke and Cerebrovascular Diseases - December 2, 2019 Category: Neurology Authors: Sophia Vassilopoulou, Eleni Korompoki, Argyro Tountopoulou, Dimos D. Mitsikostas, Efstathios Manios, Georgios Georgiopoulos, George Ntaios, Haralampos Milionis, Sophia Fontara, Konstantinos Vemmos Source Type: research

Risk factors and pathogenic microorganism characteristics for pneumonia in convalescent patients with stroke: A retrospective study of 380 patients from a rehabilitation hospital
Stroke significantly impacts public health and ranks among the leading causes of death and disabilities, resulting in enormous costs measured in both health care resources and lost productivity. It results primarily from embolus or thrombosis for ischemic stroke and hypertension for hemorrhagic stroke, respectively [1]. In 2016, there were 5.5 million deaths and 116.4 million disability-adjusted life-years (DALYs) owed to stroke [2]. As reported, the impact of stroke on the Chinese population is more severe compared to average global levels, and the prevalence of stroke continues to surpass that of ischemic heart disease [3 –4].
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Jia Xu, Zhiling Yang Source Type: research

Knowledge of Acute Stroke Management Among Healthcare Professionals: Development and Validation of Acute Stroke Management Questionnaire (ASMaQ)
Around 15.0% of all strokes occurred in hospitalised patients and studies showed significant delay in the stroke recognition and lack of awareness on thrombolytic therapy for acute ischaemic stroke (AIS) which lead to higher mortality for in-hospital stroke. We aimed to develop and validate a new instrument known as acute stroke management questionnaire (ASMaQ) to evaluate the awareness of healthcare professionals in managing acute ischaemic stroke cases.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2020 Category: Neurology Authors: Chun yang Sim, Wan Asyraf Wan Zaidi, Shamsul Azhar Shah, Wan Nur Nafisah Wan Yahya, Hui jan Tan Source Type: research

Hospital Revisits for Post-Ischemic Stroke Epilepsy after Acute Stroke Interventions
Improvements in acute stroke care, namely the use of intravenous alteplase (IV-tPA) and mechanical thrombectomy (MT), have led to a considerable increase in the proportion of patients who survive a first-time ischemic stroke.1 Despite demonstrated benefits of acute stroke interventions, their impact on long term complications is not yet clear. One such complication is post-ischemic stroke epilepsy (PISE). PISE is estimated to occur in 2 –6% of stroke survivors,2–4 and is associated with poor-quality of life and high mortality in young patients.
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2021 Category: Neurology Authors: Lindsey R. Kuohn, Alison L. Herman, Alexandria L. Soto, Stacy C. Brown, Emily J. Gilmore, Lawrence J. Hirsch, Charles C. Matouk, Kevin N. Sheth, Jennifer A. Kim Source Type: research

Transition in Incidence Rate of Hospitalised Stroke and Case Fatality Rate in the Hunter Region, Australia, 2001-2019: A Prospective Hospital-Based Study
Introduction: Continuous surveillance of stroke admissions has been conducted in the Hunter region, Australia, over the past two decades. We aimed to describe the trends in incidence rates of hospitalised stroke and case-fatality rates in this region, 2001-2019. Methods: From a hospital-based stroke registry, data for admitted adult stroke patients residing in the Hunter region were collected using ICD-10 codes for ischemic and haemorrhagic stroke. Negative binomial regression and logistic regression analysis were used to analyse trends for age-standardised and age-specific incidence rates of hospitalised stroke and 28-day...
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2022 Category: Neurology Authors: Yumi Tomari Kashida, Thomas Lillicrap, Rhonda Walker, Elizabeth Holliday, Md Golam Hasnain, Shinya Tomari, Carlos Garcia-Esperon, Jennifer J. Majersik, Neil J. Spratt, Christopher Levi Source Type: research

Is the outpatient management of acute minor stroke feasible and safe?
Paul et al1 have assessed the clinical outcomes, early hospital admission rates and hospital care costs in clinic referred and hospital referred minor stroke patients in a prospective population based study. They did not find significant differences in the 30 day admission rate in clinic patients compared with the 30 day readmission rate after discharge in hospital treated patients (16/237 vs 9/150). The 30 day recurrent stroke risk in patients with minor ischaemic stroke was also similar in those discharged from clinic compared with hospital patients (3.8% vs 5.3%; p=0.61). The recurrent stroke risk remained similar in pa...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Csiba, L. Tags: Epilepsy and seizures, Stroke, Hypertension Editorial commentaries Source Type: research

Short-term Bleeding Events Observed with Clopidogrel Loading in Acute Ischemic Stroke Patients
Discussion: Contrary to our original hypothesis, patients with AIS receiving clopidogrel loading doses within 24 hours of symptom onset did not appear to experience a higher rate of new serious bleeding events during acute hospitalization when compared with patients who did not receive loading doses. The Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke trial is expected to provide insight into the safety of clopidogrel loading as an acute intervention after cerebral ischemia.
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2013 Category: Neurology Authors: Lester Y. Leung, Karen C. Albright, Amelia K. Boehme, Joseph Tarsia, Kamal R. Shah, James E. Siegler, Erica M. Jones, Gayle R. Pletsch, Timothy M. Beasley, Sheryl Martin-Schild Tags: Original Articles Source Type: research

Racial and Gender Differences in Stroke Severity, Outcomes, and Treatment in Patients with Acute Ischemic Stroke
Background: Previous research has indicated that women and blacks have worse outcomes after acute ischemic stroke (AIS). Little research has been done to investigate the combined influence of race and gender in the presentation, treatment, and outcome of patients with AIS. We sought to determine the association of race and gender on initial stroke severity, thrombolysis, and functional outcome after AIS.Methods: AIS patients who presented to 2 academic medical centers in the United States (2004-2011) were identified through prospective registries. In-hospital strokes were excluded. Stroke severity, measured by admission Na...
Source: Journal of Stroke and Cerebrovascular Diseases - January 27, 2014 Category: Neurology Authors: Amelia K. Boehme, James E. Siegler, Michael T. Mullen, Karen C. Albright, Michael J. Lyerly, Dominique J. Monlezun, Erica M. Jones, Rikki Tanner, Nicole R. Gonzales, T. Mark Beasley, James C. Grotta, Sean I. Savitz, Sheryl Martin-Schild Tags: Original Articles Source Type: research

Does Modern Ischemic Stroke Therapy in a Large Community-based Dedicated Stroke Center Improve Clinical Outcomes? A Two-Year Retrospective Study
Background: To compare modern endovascular therapies in the acute ischemic stroke patients leading to more comprehensive acute stroke algorithm.Methods: A 2-year retrospective nonrandomized study on 76 patients who were placed into 5 different treatment groups for acute ischemic stroke. These groups included: group 1 (no treatment) (n = 24), group 2 (intravenous tissue plasminogen activator [tPA] only) (n = 18), group 3 (intra-arterial [IA] tPA) (n = 9), group 4 (Mechanical Embolus Removal in Cerebral Ischemia [MERCI]; retrieval only) (n = 17), and group 5 (combined IA/MERCI) (n = 8). Age range for all groups was 29-92 yea...
Source: Journal of Stroke and Cerebrovascular Diseases - September 9, 2013 Category: Neurology Authors: Matthew H. Berlet, Glenn W. Stambo, Merle Kelley, Kelly Van Epps, Troy Woeste, Diana Steffen Tags: Original Articles Source Type: research

The Quality of Prehospital Ischemic Stroke Care: Compliance with Guidelines and Impact on In-hospital Stroke Response
This study examined performance measure compliance among EMS-transported stroke patients and the relationship between compliance and in-hospital stroke response.
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2014 Category: Neurology Authors: John Adam Oostema, Mojdeh Nasiri, Todd Chassee, Mathew J. Reeves Source Type: research

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