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Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Sarah T Pendlebury, Peter M Rothwell, Oxford Vascular StudySummaryBackgroundRisk of dementia after stroke is a major concern for patients and carers. Reliable data for risk of dementia, particularly after transient ischaemic attack or minor stroke, are scarce. We studied the risks of, and risk factors for, dementia before and after transient ischaemic attack and stroke.MethodsThe Oxford Vascular Study is a prospective incidence study of all vascular events in a population of 92 728 people residing in Oxfordshire, UK. Patients with tran...
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Next generation sequencing in familial cerebral small vessel disease - an ongoing study
Cerebral small vessel disease (SVD) is the most common form of stroke and vascular dementia. CADASIL (notch3 mutations) is most frequent but other monogenic causes more recently identified include CARASIL (HTRA1 gene), RVCL (TREX1 gene) and COL4A1 and 2. Diagnostic tests for these are often inaccessible and expensive and there are families with clinical monogenic SVD in whom no known variants are detected. Next generation sequencing offers the potential to screen for these diseases, which present with similar phenotypes, more cost-effectively and rapidly in a single test. It could also identify novel genes underlying SVD. ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Tan, R., Markus, H. Tags: Dementia, Stroke, Memory disorders (psychiatry) Thur 21, Parallel session 5: Therapeutics Source Type: research

Occupational therapy intervention for residents with stroke living in UK care-homes.
Funded by the NIHR Health Technology Assessment (HTA) Programme, a study looking at the effects of occupational therapy delivered in care homes following a stroke has been published in the British Medical Journal. (BMJ)After dementia, a stroke is the most common health issue for people living in care homes. Stroke survivors admitted to care...
Source: NIHR Evaluation, Trials and Studies News - March 4, 2015 Category: American Health Source Type: news

Lack of vitamin D may 'raise dementia risk'
Conclusion This cohort study of more than 1,650 elderly people has found that over 5.6 years, severe vitamin D deficiency is associated with approximately twice the risk of developing dementia or Alzheimer's disease. It also found moderate deficiency is associated with a 50% increase in risk compared with healthy levels of vitamin D. With this being a cohort study, it was not able to show that low levels of vitamin D caused dementia or Alzheimer's disease – it was simply able to show an association. Other factors that can increase the risk of developing dementia, such as a poor diet, lack of activity and general poor h...
Source: NHS News Feed - August 7, 2014 Category: Consumer Health News Tags: Lifestyle/exercise Older people Neurology Mental health Source Type: news

Dementia rates dropping
Conclusion This study suggests that the prevalence of dementia in over 65s in 2011 is lower than would have been expected.  The study had many strengths, including the large number of people it interviewed from different areas and the consistent research methods adopted in 1991 and again in 2011, particularly using the same criteria to diagnose dementia at both time points. This means we can be relatively sure that its conclusions are reliable. That said, it does have some limitations to consider. The response rate in 2011 (56%) was much lower than in 1991 (80%). The study authors offer a number of explanations for this...
Source: NHS News Feed - July 17, 2013 Category: Consumer Health News Tags: Neurology Older people Medical practice Source Type: news

Care commissioning process is too laborious, report concludes
Source: BMJ, Nuffield Trust Area: News BMJ News features a story on a report by the Nuffield Trust which highlights the findings of an in-depth study of commissioning for people with long-term conditions. The study was funded by the National Institute for Health Research Health Services and Delivery Research (NIHR HS&DR) Programme. The Nuffield Trust carried out a 15 month (November 2010 to January 2012) study of commissioning practice in three high-performing primary care trust (PCT) areas (Calderdale, Somerset and the Wirral). The authors carried out detailed observation around what the trusts actually did around co...
Source: NeLM - News - March 1, 2013 Category: Drugs & Pharmacology Source Type: news