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Intracranial calcifications in childhood: Part 2
This article is the second of a two-part series on intracranial calcification in childhood. In Part 1, the authors discussed the main differences between physiological and pathological intracranial calcification. They also outlined histological intracranial calcification characteristics and how these can be detected across different neuroimaging modalities. Part 1 emphasized the importance of age at presentation and intracranial calcification location and proposed a comprehensive neuroimaging approach toward the differential diagnosis of the causes of intracranial calcification. Pathological intracranial calcification can ...
Source: Pediatric Radiology - July 7, 2020 Category: Radiology Source Type: research

Transcutaneous Electrical Nerve Stimulation in Relieving Neuropathic Pain: Basic Mechanisms and Clinical Applications
AbstractPurpose of ReviewTranscutaneous electrical nerve stimulation (TENS) is widely used as a non-pharmacological approach for pain relief in a variety of clinical conditions. This manuscript aimed to review the basic mechanisms and clinical applications regarding the use of TENS for alleviating the peripheral (PNP) and central neuropathic pain (CNP).Recent FindingsBasic studies on animal models showed that TENS could alleviate pain by modulating neurotransmitters and receptors in the stimulation site and its upper levels, including the spinal cord, brainstem, and brain. Besides, many clinical studies have investigated t...
Source: Current Pain and Headache Reports - February 17, 2020 Category: Neurology Source Type: research

The immunocompromised district in dermatology: A unifying pathogenic view of the regional immune dysregulation.
Abstract Besides the systemic immune deficiency, a sectorial default in immune control may occur in immunocompetent subjects. This regional immune defect can appear and remain confined to differently damaged skin areas, lately labeled immunocompromised districts (ICDs). An ICD is a skin area more vulnerable than the rest of the body for genetic or acquired reasons. Its vulnerability mainly consists in a local dysregulation of the immune control, which often facilitates (but sometimes hinders) the local onset of immunity-related eruptions or skin disorders. The factors responsible for localized immune dysregulation...
Source: Herpes - August 30, 2014 Category: Infectious Diseases Authors: Ruocco V, Ruocco E, Piccolo V, Brunetti G, Guerrera LP, Wolf R Tags: Clin Dermatol Source Type: research

The immunocompromised district in dermatology: A unifying pathogenic view of the regional immune dysregulation
Abstract: Besides the systemic immune deficiency, a sectorial default in immune control may occur in immunocompetent subjects. This regional immune defect can appear and remain confined to differently damaged skin areas, lately labeled immunocompromised districts (ICDs).An ICD is a skin area more vulnerable than the rest of the body for genetic or acquired reasons. Its vulnerability mainly consists in a local dysregulation of the immune control, which often facilitates (but sometimes hinders) the local onset of immunity-related eruptions or skin disorders.The factors responsible for localized immune dysregulation are multi...
Source: Clinics in Dermatology - August 25, 2014 Category: Dermatology Authors: Vincenzo Ruocco, Eleonora Ruocco, Vincenzo Piccolo, Giampiero Brunetti, Luigi Pio Guerrera, Ronni Wolf Source Type: research

Potential Misdiagnoses of Bell's Palsy in the Emergency Department
Conclusion: Emergency providers have a very low rate of misdiagnosing Bell's palsy. The association between imaging use and misdiagnosis is likely confounded by patient acuity. Increasing age and diabetes are modest risk factors for misdiagnosis.
Source: Annals of Emergency Medicine - July 29, 2013 Category: Emergency Medicine Authors: Jahan Fahimi, Babak B. Navi, Hooman Kamel Tags: Neurology Source Type: research