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Increased risk of ischaemic stroke amongst patients with chronic osteomyelitis: a population‐based cohort study in Taiwan
ConclusionsThis is the first report linking COM to an increased risk of developing stroke. Results suggest that COM is a significant stroke risk factor and call for closer attention to this group of patients for more rigorous stroke prevention, especially in the younger age group.
Source: European Journal of Neurology - March 1, 2014 Category: Neurology Authors: C.‐H. Tseng, J.‐H. Chen, C.‐H. Muo, Y.‐J. Chang, F.‐C. Sung, C. Y. Hsu Tags: Original Article Source Type: research

Outcomes of Chopart Amputation in a Tertiary Referral Diabetic Foot Clinic: Data From a Consecutive Series of 83 Hospitalized Patients
Publication date: Available online 24 November 2015 Source:The Journal of Foot and Ankle Surgery Author(s): Ezio Faglia, Giacomo Clerici, Robert Frykberg, Maurizio Caminiti, Vincenzo Curci, Francesco Cetta, Vincenzo Prisco, Rosaria Greco, Marco Prisco, Alberto Morabito The purpose of the present retrospective study was to evaluate the outcomes (ie, ulcer recurrence, major amputation, death) in diabetic patients undergoing Chopart amputation because of deep infection or gangrene extending to the midfoot. From 2009 to 2011, 83 patients, aged 71.4 ± 9.3 years, underwent a midtarsal amputation and were followed...
Source: The Journal of Foot and Ankle Surgery - November 26, 2015 Category: Orthopaedics Source Type: research

Increased risk of coronary heart disease in patients with chronic osteomyelitis: a population-based study in a cohort of 23 million
Conclusions This study demonstrates that COM is an independent risk factor for CHD, particularly in the younger population. Further studies are necessary to explore the underlying mechanisms linking COM and CHD.
Source: Heart - August 21, 2014 Category: Cardiology Authors: Hsiao, L.-C., Muo, C.-H., Chen, Y.-C., Chou, C.-Y., Tseng, C.-H., Chang, K.-C. Tags: Health policy, Drugs: cardiovascular system, Hypertension, Epidemiology, Metabolic disorders Coronary artery disease Source Type: research

Increased depression risk among patients with chronic osteomyelitis
Inflammatory processes, which provoke alternations of neurotransmitter metabolism, neuroendocrine function, and neuroplasticity in the brain, might promote depression. In depression patients who do not exhibit risk factors, including hypertension, diabetes, coronary heart disease, stroke, Parkinson's disease and dementia, particularly in young people, inflammation is a likely risk factor for depression. We explored whether chronic osteomyelitis (COM), a chronic inflammatory disease, increases depression risk.
Source: Journal of Psychosomatic Research - September 14, 2014 Category: Psychiatry & Psychology Authors: Chun-Hung Tseng, Wei-Shih Huang, Chih-Hsin Muo, Yen-Jung Chang, Chia-Hung Kao Source Type: research

Increased risk of dementia among chronic osteomyelitis patients
This study investigates whether COM increases the risk of dementia. Taiwanese National Health Insurance (NHI) inpatient claims were used to identify 17,238 patients newly diagnosed with COM from 2000 to 2008, and 68,944 age- and gender-matched patients without COM were randomly selected for comparison. Risks of dementia associated with COM and comorbidities, including hypertension, diabetes, stroke, hyperlipidemia, and depression, were evaluated using data from the end of 2011. Dementia risk was 1.6-fold higher (95 % confidence interval [CI]: 1.4–1.83) in the COM cohort than in the control group, calculated using the mu...
Source: European Journal of Clinical Microbiology and Infectious Diseases - January 1, 2015 Category: Microbiology Source Type: research

Variations and characteristics of the various clinical phenotypes in a cohort of Nigerian sickle cell patients
CONCLUSION: The prevalence of SLU, AVN, priapism, nephropathy and the other complications of SCD show some variations from other studies. This variation in the clinical parameters across different clinical phenotypes indicates an interplay between age, genetic and environmental factors.PMID:34493173 | DOI:10.1080/16078454.2021.1972242
Source: Hematology - September 8, 2021 Category: Hematology Authors: Augustine Duru Anazoeze Jude Madu Helen Okoye Charles Nonyelu Onochie Obodo Kelechi Okereke Kenechi Madu Source Type: research