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Cerebral infarction due to Zika virus
We read with great interest the letter by Anne Landais and colleagues entitled, “ZIKA vasculitis: A new cause of stroke in children.” [1] The article presents a case of an acute left middle cerebral artery infarct in an eight-month old boy within a few days of symptomatic Zika infection. He had positive Zika PCR in serum followed a few months later by positive Zika IgG and negative Zika IgM. The authors report this as the first case of cerebral infarction associated with Zika infection, broadening the clinical neurologic spectrum of Zika infection.
Source: Journal of the Neurological Sciences - February 3, 2018 Category: Neurology Authors: Sarah B. Mulkey, Roberta L. DeBiasi, Adre J. du Plessis Tags: Letter to the Editor Source Type: research

New spectrum of the neurologic consequences of Zika
Zika virus infection represents a new neuropathological agent with association to a wide spectrum of neurological complications: a) Congenital Zika Syndrome by affecting the neural stem cells of the human fetal brain; b) Guillain-Barr é Syndrome by an autoimmune response against peripheral myelin and/or axonal components or probable direct inflammatory reaction; c) Encephalitis/meningoencephalitis and myelitis by a direct viral inflammatory process on the central nervous system; d) Sensory neuropathy by infecting directly the pe ripheral neurons and causing substantial cell death and pathogenic transcriptional dysregulati...
Source: Journal of the Neurological Sciences - October 31, 2017 Category: Neurology Authors: Marco T. Medina, Marco Medina-Montoya Tags: Editorial Source Type: research

ZIKA vasculitis: A new cause of stroke in children?
Viral infectious vasculitis is a cause of stroke in children. Zika virus infection is often asymptomatic. Neurological complications have however been reported: Guillain-Barr é, ADEM, meningoencephalitis, myelitis, microcephaly in the fetus of infected mothers. We discuss the case of a child presenting acute infection with ZIKV that was associated with a stroke. A 10-months-old boy without medical history presented after 2days of fever and cutaneous rash, conjunctivitis on day 5, a right hemiparesis on day 6.
Source: Journal of the Neurological Sciences - October 27, 2017 Category: Neurology Authors: Anne Landais, Audrey C ésaire, Manuel Fernandez, Sébastien Breurec, Cécile Herrmann, Fréderique Delion, Philippe Desprez Tags: Letter to the Editor Source Type: research