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Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Medical Complications After Adult Spinal Deformity Surgery: Incidence, Risk Factors, and Clinical Impact
Conclusion. Risk factors for the development of postoperative medical complications after correction of ASD include smoking, hypertension, and duration of symptoms. Patients who have one or more of these risk factors should be identified and informed during informed consent of their increased risks. They should be optimized preoperatively, and followed closely during the postoperative period. Level of Evidence: 3
Source: Spine - November 12, 2016 Category: Orthopaedics Tags: Deformity Source Type: research

Length of hospital stay is shorter in south Asian patients with transient ischaemic attack
Every year, 46 000 people in the United Kingdom (UK) suffer a de novo transient ischaemic attack (TIA) [1]. In 2012, 1 in 20 individuals who experienced a TIA progressed to suffering a stroke within seven days of the index TIA [2]. According to the literature, factors influencing the length of hospital stay (LOS) in TIA include age, female sex, known comorbidities (based on Charlson Comorbidities Index), patients that were transferred to another hospital, occurrence of an adverse event (urinary tract infection, Clostridium difficile), diagnosis of pneumonia, hemiplegia and paraplegia [3] and availability of urgent referral...
Source: International Journal of Cardiology - November 3, 2015 Category: Cardiology Authors: Ignatius Liew, Paul Carter, Jennifer Reynolds, Nicholas D. Gollop, Hardeep Uppal, Suresh Chandran, Rahul Potluri Source Type: research

Length of hospital stay is shorter in South Asian patients with transient ischemic attack
Every year, 46,000 people in the United Kingdom (UK) suffer a de novo transient ischemic attack (TIA) [1]. In 2012, 1 in 20 individuals who experienced a TIA progressed to suffering a stroke within seven days of the index TIA [2]. According to the literature, factors influencing the length of hospital stay (LOS) in TIA include age, female sex, known comorbidities (based on Charlson Comorbidities Index), patients that were transferred to another hospital, occurrence of an adverse event (urinary tract infection, Clostridium difficile), diagnosis of pneumonia, hemiplegia and paraplegia [3] and availability of urgent referral ...
Source: International Journal of Cardiology - November 3, 2015 Category: Cardiology Authors: Ignatius Liew, Paul Carter, Jennifer Reynolds, Nicholas D. Gollop, Hardeep Uppal, Suresh Chandran, Rahul Potluri Tags: Correspondence Source Type: research

Prophylactic antibiotics after acute stroke for reducing pneumonia in patients with dysphagia (STROKE-INF): a prospective, cluster-randomised, open-label, masked endpoint, controlled clinical trial
This study assessed the effectiveness of antibiotic prophylaxis for reducing pneumonia in patients with dysphagia after acute stroke. Methods We did a prospective, multicentre, cluster-randomised, open-label controlled trial with masked endpoint assessment of patients older than 18 years with dysphagia after new stroke recruited from 48 stroke units in the UK, accredited and included in the UK National Stroke Audit. We excluded patients with contraindications to antibiotics, pre-existing dysphagia, or known infections, or who were not expected to survive beyond 14 days. We randomly assigned the units (1:1) by computer to ...
Source: The Lancet - September 5, 2015 Category: Journals (General) Source Type: research