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Increased Plasma Matrix Metalloproteinase-9 Levels Contribute to Intracerebral Hemorrhage during Thrombolysis after Concomitant Stroke and Influenza Infection
Conclusion: Preexisting influenza A virus infection led to increased plasma MMP-9 and TIMP-1 levels in mice undergoing thrombolysis after induced stroke. MMP-9 levels closely correlated with intracerebral bleeding after thrombolysis during concomitant infection and stroke. Thus, our data indicate that thrombolysis may be dangerous during influenza infection. MMP-9 inhibitors might be considered to reduce the side effects of thrombolysis during concomitant infection and stroke.Cerebrovasc Dis Extra 2016;6:50-59
Source: Cerebrovascular Diseases Extra - August 24, 2016 Category: Neurology Source Type: research

Neurological injuries and extracorporeal membrane oxygenation: the challenge of the new ECMO era
We present a case series of six neurological injuries that occurred in 1 year during the ECMO run or after the ECMO weaning. In each case the neurological complication had a dramatic effect: ranging from brain death to prolonged ICU stay and long term disability. This case series has an informative impact for the multidisciplinary teams treating ECMO patients because of its heterogeneity in pathogenesis and clinical manifestation: cerebral hemorrhage, ischemic stroke due to cerebral fat embolism, acute disseminated encephalomyelitis due to H1N1 Influenza. In our ECMO hub we started strict neurological monitoring involving...
Source: Neurological Sciences - February 19, 2016 Category: Neurology Source Type: research

Ictogenesis of viral pneumonia: A comparison between SARS-CoV-2 and H1N1/H3N2
Epilepsy Behav. 2021 Dec 10;126:108470. doi: 10.1016/j.yebeh.2021.108470. Online ahead of print.ABSTRACTSeveral studies reported acute symptomatic seizures as a possible neurological complication of COVID-19 pneumonia. Apart from metabolic imbalances, hypoxia, and fever, other ictogenic mechanisms are likely related to an immune-mediated damage. The same mechanisms are shared by other respiratory viruses. Since neurotropic properties of SARS-CoV-2 have been questioned, we investigated whether SARS-CoV-2 has a similar ictogenic potential to other respiratory non-neurotropic viruses. We conducted a retrospective study identi...
Source: Epilepsy and Behaviour - December 13, 2021 Category: Neurology Authors: Chiara Milano Francesco Turco Chiara Pizzanelli Alessia Pascazio Enrico Tagliaferri Lorenzo Nesti Mauro Pistello Anna Lisa Capria Francesco Menichetti Francesco Forfori Enrica Bonanni Gabriele Siciliano Source Type: research