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Predicting the response to methylprednisolone pulses in patients with SARS-COV-2 infection
CONCLUSIONS: In patients with methylprednisolone pulses, the capacity of the predictive model for hospital discharge including variables collected at 5 days was (area under the curve) 0.816.PMID:35718548 | DOI:10.1016/j.medcli.2022.02.025
Source: Medicina Clinica - June 19, 2022 Category: General Medicine Authors: Antonio J Sarri á-Landete Jos é A Crespo-Matas Inmaculada Dom ínguez-Quesada Jes ús J Castellanos-Monedero Din és Marte-Acosta Ángel J Arias-Arias Source Type: research

Neurologic Symptoms Are Very Common Among U.S. Coronavirus Patients, Study Says
As the COVID-19 pandemic stretches on, so too does the disease’s list of known symptoms. At first, cough, fever and shortness of breath were thought to be its primary symptoms. Nine months in, that list now includes organ damage, skin conditions, gastrointestinal problems and issues of the brain and nervous system. A paper published Oct. 5 in the Annals of Clinical and Translational Neurology is thought to be the first to examine the prevalence of neurologic symptoms in U.S. COVID-19 patients. Out of 509 people admitted to Chicago hospitals for coronavirus care this spring, 82% had a neurologic symptom at some point,...
Source: TIME: Health - October 5, 2020 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 Source Type: news

Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway
Conclusion In summary, we demonstrated that geniposide alleviated GC-induced osteogenic suppression in MC3T3-E1 cells. The effects of geniposide were at least partially associated with activating ERK signaling pathway via GLP-1 receptor. Geniposide might be a potential therapeutic agent for protection against GC-induced osteoporosis. Author Contributions BX, DX, CZ, and LW participated in research design. BX, JW, YL, XW, and ZZ conducted the experiments. BX, DX, and LW contributed new reagents or analytic tools and wrote or contributed to the writing of the manuscript. BX, JW, CZ, and DX performed the data analysis. Fu...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research