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Source: European Respiratory Journal
Condition: Pulmonary Hypertension
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Total 34 results found since Jan 2013.
Acute beat blockade improves right ventricular diastolic filling in pulmonary arterial hypertension: a rodent CMR and clinical human pressure-volume study
Conclusions: Esmolol improves RV diastolic filling in PAH at rest and during low-grade exercise, preserving SV and CO, with energetically favourable effects on contractile efficiency.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Samaranayake, C., Niglas, M., Kempny, A., Baxan, N., Ashek, A., Pinguel, J., Dimopoulos, K., Price, L. C., Wort, S. J., Zhao, L., Mccabe, C. Tags: 13.01 - Pulmonary hypertension Source Type: research
A fully automated cardiac magnetic resonance (CMR) assessment improves the evaluation of patients with pulmonary arterial hypertension (PAH)
Conclusion: In a prospective PAH cohort, fully automatic CMR assessments were reliable and corresponded accurately to invasive hemodynamics
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Alabed, S., Karunasaagarar, K., Alandejani, F., Salehi, M., Aldabbagh, Z., Garg, P., Uthoff, J., Lu, H., Wild, J., Kiely, D., Van Der Geest, R., Swift, A. Tags: Imaging Source Type: research
Controversies over the impact of the COVID-19 pandemic on patients with Pulmonary Arterial Hypertension
This study is a retrospective analysis of our PAH patients treated in 2020 compared to the dynamics of the last 12 years. We had 48 PAH patients, 51.72±16.64 years, 72.91% female. All patients had chronic anticoagulant therapy(58.33%) and/or antiplatelet; 33.33% had long term oxygen therapy. Three patients with secondary forms were confirmed with COVID-19, all hospitalized (6.25% infection rate versus 3.29% in general). One patient died(75 years with scleroderma, stroke), two patients were cured (mild forms). In total only three patients died in 2020. Surprisingly, compared with 2008-2019 (101 patients/ 41 deaths, 3...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Bertici, N. S., Dobrescu, L., Pislaru, L., Marincu, I. Tags: Pulmonary hypertension Source Type: research
REPAIR: long-term effects of macitentan on the right ventricle (RV) in pulmonary arterial hypertension (PAH)
Conclusions: Improvements in RV mass, volume and function observed with macitentan at Week 26 were maintained at Week 52. BL*Mean (SD)nBL to Week 26 change(95% CL)nBL to Week 52 change(95% CL)RVSV (mL)#52.2 (17.2)7112.0 (8.4, 15.6)||6312.0 (8.4, 15.6)||RV end diastolic vol (mL)149.8 (49.1)70–6.2 (–12.8, 0.4)§63–5.3 (–12.0, 1.4)§RV end systolic vol (mL)90.2 (40.6)70–16.1(–20.0, –12.2)63–17.0(–22.1, –12.0)RV ejection fraction (%)#37.7 (14.3)7010.6 (7.9, 13.3)629.5 (7.0, 12.0)RV mass (g)110.4 (47.5)70–10.5(–14.0, –7.1)63–9.2(–1...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kiely, D., Cottreel, E., Galie, N., Marcus, J. T., Peacock, A., Rosenkranz, S., Swift, A. J., Tawakol, A., Torbicki, A., Vonk Noordegraaf, A., Wetherill, G., Channick, R. Tags: Pulmonary hypertension Source Type: research
Cardiac function and pulmonary hypertension in Central Asian highlanders at 3250 m
The question addressed by the study
Chronic exposure to hypoxia increases pulmonary artery pressure (PAP) in highlanders, but the criteria for diagnosis of high-altitude pulmonary hypertension (HAPH) are debated. We assessed cardiac function and PAP in highlanders at 3250 m and explored HAPH prevalence using different definitions.
Patients and methods
Central Asian highlanders free of overt cardiorespiratory disease, permanently living at 2500–3500 m compared to age-matched lowlanders living <800 m. Participants underwent echocardiography close to their altitude of residence (at 3250 m versus ...
Source: European Respiratory Journal - August 19, 2020 Category: Respiratory Medicine Authors: Lichtblau, M., Saxer, S., Furian, M., Mayer, L., Bader, P. R., Scheiwiller, P. M., Mademilov, M., Sheraliev, U., Tanner, F. C., Sooronbaev, T. M., Bloch, K. E., Ulrich, S. Tags: Pulmonary vascular disease Original Articles: Pulmonary hypertension Source Type: research
When it all comes down to pressure: right ventricular ejection fraction at cardiac catheterisation
In the present issue of the European Respiratory Journal, Heerdt et al. [1] report on the validation of right ventricularejection fraction (RVEF) calculated from a pressure curve at cardiac catheterisation. This is of great interest as right ventricular (RV) function is the main determinant of symptomatology and outcome in pulmonary hypertension [2], and RVEF accordingly adds significantly to risk stratification in these patients [3]. However, ejection fraction (EF) is a ratio of stroke volume (SV) to end-diastolic volume (EDV), with no pressure in the equation. So, how is it possible to calculate a volume ratio from pressure measurements?
Source: European Respiratory Journal - March 11, 2020 Category: Respiratory Medicine Authors: Naeije, R., Richter, M. J., Vanderpool, R., Tello, K. Tags: Editorials Source Type: research
Rest and exercise pulmonary arterial compliance in patients with pulmonary fibrosis
Conclusion: C correlates with markers of pulmonary vasculopathy. The drop of C from rest to exercise may represent an important factor of functional limitation in PF patients.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Panagiotidou, E., Stanopoulos, I., Papakosta, D., Fouka, E., Akritidou, S., Bagalas, V., Boutou, A., Pitsiou, G. Tags: Pulmonary hypertension Source Type: research
MnTBAP reduces pulmonary vascular remodeling in experimental pulmonary arterial hypertension
Conclusion: MnTBAP treatment can partly reverse RV afterload and pulmonary vascular remodeling in established experimental PAH. Together with the improved cardiac function, MnTBAP may be a promising intervention for PAH.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Sun, X.-Q., Gomez-Puerto, M. C., Schalij, I., Vonk-Noordegraaf, A., De Man, F. S., Ten Dijke, P., Bogaard, H.-J. Tags: Pulmonary hypertension Source Type: research
Late Breaking Abstract - The effect of exercise rehabilitation on cardiac function, measured by cardiac MRI, in patients with pre-capillary pulmonary hypertension
Conclusion: Exercise rehabilitation in pre-capillary PH led to significant improvements in cardiac output, stroke volume and right ventricular ejection fraction (EF). Small numbers limited results. Further work is required to assess long term benefits.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: McGettrick, M., Jayasekera, G., Brewis, M., Church, C., Johnson, M., Mackenzie, A. Tags: Right ventricle Source Type: research
Predictors of physical activity in pulmonary arterial and chronic thromboembolic pulmonary hypertension
Conclusions: Daily physical activity as steps/day assessed in patients newly diagnosed with PAH/CTEPH did not well correlate with invasive hemodynamics at rest nor during exercise, but very well with the 6MWD. Whether daily activity assessments provide additional information to simple walk distance on risk factor profiles during follow-up in patients with PAH/CTEPH remains to be clarified.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Saxer, S., Lichtblau, M., Berlier, C., Hasler, E., Schwarz, E., Ulrich, S. Tags: Pulmonary hypertension Source Type: research
Vena cava backflow and right ventricular stiffness in pulmonary arterial hypertension
Vena cava backflow is a well-recognised clinical hallmark of right ventricular failure in pulmonary arterial hypertension (PAH). Backflow may result from tricuspid regurgitation during right ventricular systole or from impaired right ventricular diastolic filling during atrial contraction. Our aim was to quantify the forward and backward flow in the vena cava and to establish the main cause in PAH.
In 62 PAH patients, cardiac magnetic resonance measurements provided volumetric flows (mL·s–1) in the superior and inferior vena cava; time integration of flow gave volume. The "backward fraction" was defined as the...
Source: European Respiratory Journal - October 16, 2019 Category: Respiratory Medicine Authors: Marcus, J. T., Westerhof, B. E., Groeneveldt, J. A., Bogaard, H. J., de Man, F. S., Vonk Noordegraaf, A. Tags: Pulmonary vascular disease Original Articles: Pulmonary hypertension Source Type: research
Reappraising the effects of pulmonary artery wedge pressure on right ventricular pulsatile loading
Conclusion: Unexpectedly, PAWP decreased RV pulsatile loading (as reflected in PA stiffness) when potential confounding factors, including the prevailing mPAP, were taken into account. Our results deserve further independent confirmation.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Chemla, D., Berthelot, E., Weatherald, J., Savale, L., Attal, P., Montani, D., Sitbon, O., Humbert, M., Herve, P., Assayag, P. Tags: Pulmonary hypertension Source Type: research
Right ventricular size and contractile reserve significantly correlate in patients with pulmonary hypertension
Conclusion: RV and RA area represent valuable and easily accessible indicators of RV pump function during exercise and might therefore be used for non-invasive estimation of right ventricular contractile reserve. CIPeak should be considered as an important clinical parameter. Prospective studies are needed for further evaluation.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Fischer, L., Benjamin, N., Egenlauf, B., Harutyunova, S., Lorenz, H.-M., Blank, N., Marra, A. M., Nagel, C., Fischer, C., Gruenig, E. Tags: Pulmonary hypertension Source Type: research
Echocardiographic assessment in lowlanders vs. highlanders living above 2500m
Conclusion: Chronic exposure to hypoxia in HL promotes a rise in pulmonary artery pressure and a decreased right heart function compared to LL.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lichtblau, M., Saxer, S., Bader, P., Furian, M., Scheiwiller, P., Mademilov, M., Estebesova, B., Osmonov, B., Marazhapov, N., Sheraliev, U., Sooronbaev, T., Bloch, K., Ulrich, S. Tags: Pulmonary hypertension Source Type: research
Lower than expected pulsatile pulmonary arterial load in a thromboembolic pulmonary hypertension model
Conclusions: To our knowledge, this is the first documentation of a PH state where the mPAP-corrected indices of pulsatile arterial load (sPAP, PAPp) were lower than expected. The young age of the animals, the short-term nature of our analysis, or some specific features of the thromboembolic PH model may be involved.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Boulate, D., Chemla, D., Loisel, F., Coblence, M., Provost, B., Decante, B., Herve, P., Fadel, E., Mercier, O. Tags: Pulmonary hypertension Source Type: research
