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Association of Black Race With Early Recurrence After Minor Ischemic Stroke or Transient Ischemic Attack
This secondary analysis of the POINT randomized clinical trial examines the association between race and risk of early ischemic stroke recurrence after a minor ischemic stroke or transient ischemic attack among US participants.
Source: JAMA Neurology - February 24, 2020 Category: Neurology Source Type: research

Characteristics of Recurrent Ischemic Stroke After ESUS
This secondary analysis of a randomized clinical trial assesses the subtype of recurrent ischemic stroke after embolic stroke of underdetermined source, the interaction with treatment assignment, and the consistency of cerebral location of the qualifying and recurrent strokes in the study population of the NAVIGATE-ESUS trial.
Source: JAMA Neurology - July 6, 2020 Category: Neurology Source Type: research

Questions on Predicting Early Neurological Deterioration in Patients With Minor Stroke and Large-Vessel Occlusion
To the Editor We read with great interest the article by Seners and colleagues in which they investigated predictors of early neurological deterioration of presumed ischemic origin (ENDi) in large-vessel occlusion stroke with minor clinical deficits and developed a 4-point risk prediction score of ENDi. This is a common and probably underrecognized problem in large-vessel occlusion stroke, and characterizing patients at risk of ENDi is highly relevant for patient management.
Source: JAMA Neurology - July 6, 2021 Category: Neurology Source Type: research

Efficacy and Safety of Ticagrelor and Aspirin in Patients With Moderate Ischemic Stroke
This exploratory analysis of the THALES trial evaluates the efficacy and safety of ticagrelor plus aspirin in patients with moderate ischemic stroke (National Institutes of Health Stroke Scale score of 4 to 5).
Source: JAMA Neurology - July 9, 2021 Category: Neurology Source Type: research

Infarct on Brain Imaging, Subsequent Ischemic Stroke, and Clopidogrel-Aspirin Efficacy
This post hoc analysis of a randomized clinical trial investigates whether the association of clopidogrel-aspirin treatment with stroke recurrence in patients with minor stroke or high-risk transient ischemic attack is modified by the presence of infarct on imaging attributed to the index event.
Source: JAMA Neurology - January 18, 2022 Category: Neurology Source Type: research

Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the ARIC Cohort Study
This cohort study evaluates the association between risk of dementia and incident ischemic stroke by stroke severity and recurrence.
Source: JAMA Neurology - January 24, 2022 Category: Neurology Source Type: research

Data Do Not Support Selection of Patients for Stroke Treatment Within the 16- to 24-Hour Interval —Reply
In Reply We thank Powers for his comments regarding our article. He raises the question if the positive result for patients with target perfusion-imaging mismatch in the 12.8- to 24-hour tercile in the Analysis of Pooled Data From Randomized Studies of Thrombectomy More Than 6 Hours After Last Well Known (AURORA) study could solely be due to a benefit from 12.8 to 16 hours since last known well subgroup, with neutral or negative effects in the 16- to 24-hour time period. This was not the case. Data for patients in the 16- to 24-hour group with the target mismatch profile demonstrated an odds ratio of 3.82 (95% CI, 1.07-13....
Source: JAMA Neurology - February 14, 2022 Category: Neurology Source Type: research

Evaluating Rates of Recurrent Ischemic Stroke Among Young Adults With Embolic Stroke of Undetermined Source
This cohort study evaluates rates of and factors associated with recurrent ischemic stroke and death as well as new-onset atrial fibrillation among younger adults.
Source: JAMA Neurology - March 14, 2022 Category: Neurology Source Type: research

Association Between ASPECTS and Efficacy and Safety Outcomes With EVT in Patients With Stroke
This secondary analysis of the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism —Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT) evaluates the safety and efficacy of endovascular therapy in patients with acute large ischemic stroke by Alberta Stroke Program Early Computed Tomography Score.
Source: JAMA Neurology - October 10, 2022 Category: Neurology Source Type: research

Quantification of Penumbral Volume in Association With Time From Stroke Onset in Acute Ischemic Stroke
This cross-sectional study examines changes in the penumbral and core volumes over time to imaging in patients with acute ischemic stroke.
Source: JAMA Neurology - March 20, 2023 Category: Neurology Source Type: research

Association Between Magnitude of Differential Blood Pressure Reduction and Secondary Stroke Prevention
This meta-analysis and meta-regression of randomized clinical trials evaluates the association of magnitude of differential blood pressure reduction and recurrent stroke in patients with stroke or transient ischemic attack.
Source: JAMA Neurology - March 20, 2023 Category: Neurology Source Type: research

Genetic Variants Associated With Risk of Ischemic Stroke
This genome-wide association study identifies 2 novel genes, PDE4DIP and ACOT4, that are associated with an increased risk for ischemic stroke.
Source: JAMA Neurology - May 11, 2015 Category: Neurology Source Type: research

Selection Criteria for Stroke Patients Likely to Benefit From Thrombectomy
This cohort study of patients with anterior circulation ischemic stroke compared outcomes after thrombectomy of patients classified as likely vs unlikely to benefit from the procedure based on clinical criteria and MRI findings.
Source: JAMA Neurology - November 2, 2015 Category: Neurology Source Type: research

Recurrent Ischemic Stroke Factors in the SAMMPRIS Medical Group
This post hoc analysis of a randomized clinical trial aims to determine baseline features that were associated with a high rate of the primary end point in the medical arm of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial.
Source: JAMA Neurology - January 4, 2016 Category: Neurology Source Type: research

Stent Retrievers for Acute Ischemic Stroke
This meta-analysis of randomized clinical trials aims to quantify the benefits and risks of using stent retrievers in addition to recombinant tissue plasminogen activator for the treatment of acute ischemic stroke.
Source: JAMA Neurology - January 25, 2016 Category: Neurology Source Type: research

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