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Source: JAMA Neurology
Condition: Ischemic Stroke
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Total 201 results found since Jan 2013.
Coexistent Small Vessel Disease and Intracranial Arterial Stenosis
This post hoc analysis of a clinical trial evaluated the risk of ischemic stroke in patients with large artery atherosclerosis and coexistent small vessel disease.
Source: JAMA Neurology - November 30, 2015 Category: Neurology Source Type: research
Affiliation Error in Group Information Listing
This article was corrected online and in print.
Source: JAMA Neurology - February 8, 2016 Category: Neurology Source Type: research
Omitted Author Affiliation
This article was corrected online.
Source: JAMA Neurology - February 22, 2016 Category: Neurology Source Type: research
Prediction of Early Recurrence After Acute Ischemic Stroke
This study tests the validity of a prognostic score that was exclusively developed to predict early risk of recurrence in a multicenter setting.
Source: JAMA Neurology - February 29, 2016 Category: Neurology Source Type: research
Hemodynamics in Atherosclerotic Vertebrobasilar Occlusive Disease
In Reply We read with interest the letter by Walcott et al and thank them for their insightful comments. They note that whereas in carotid stenosis, artery-to-artery embolism is a common culprit, hypoperfusion as determined by the Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke protocol is the main pathological mechanism in patients with vertebrobasilar disease and low-flow status. In their experience, a number of patients with medically refractory vertebrobasilar disease symptoms were successfully treated with surgical revascularization in the form of a microsurgical bypass and they make t...
Source: JAMA Neurology - April 18, 2016 Category: Neurology Source Type: research
Cerebral Microbleeds, Cognition and Therapeutic Implications
A recent major clinical advance in magnetic resonance imaging (MRI) of the brain is the development of paramagnetic-sensitive sequences such as T2-weighted gradient-recalled echo and susceptibility-weighted images for the detection of cerebral microbleeds (CMBs). On brain MRI, CMBs are small (≤5 to 10 mm in diameter), round, dark-signaled lesions that consist of extravasation of blood components through fragile microvascular walls that neuropathologically represent hemosiderin-laden macrophages. Magnetic resonance imaging–detected CMBs are common in elderly individuals, coexist with ischemic stroke and intracerebral he...
Source: JAMA Neurology - June 6, 2016 Category: Neurology Source Type: research
Dementia After Intracerebral Hemorrhage
As acute management of intracerebral hemorrhage (ICH) has improved, more patients survive ICH but are left with significant deficits. In the past, primary evaluations of outcomes after ICH have focused on mortality and levels of functional dependence, with a relatively modest number of patients experiencing true functional independence after ICH or returning to their previous level of functioning. Cognitive outcomes after ICH have thus not been a primary focus of either treatment or natural history studies of ICH, despite their known importance after ischemic stroke and their importance in predicting return to previous functioning.
Source: JAMA Neurology - June 13, 2016 Category: Neurology Source Type: research
Proton Pump Inhibitors and Dementia Incidence
To the Editor I read with interest the article by Gomm and colleagues, which examined the association between the use of proton pump inhibitors (PPIs) and incident dementia in elderly individuals in a prospective study. The authors adopted time-dependent Cox regression analysis, and the time-dependent covariates were polypharmacy and the comorbidities of depression, diabetes, ischemic heart disease, and stroke. Age and sex were also used as confounding factors. The hazard ratio of PPIs for incident dementia was 1.44 (95% CI, 1.36-1.52), and the authors recommended randomized clinical trials to confirm the causal associatio...
Source: JAMA Neurology - June 20, 2016 Category: Neurology Source Type: research
The Dark Matter of Cerebral Microbleeds
In Reply We thank Charidimou for reading our recently published article in JAMA Neurology on the risk for symptomatic intracerebral hemorrhage after intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) and high cerebral microbleed (CMB) burden on pre-IVT magnetic resonance imaging (MRI) screening, and for his timely discussion on the topic.
Source: JAMA Neurology - August 15, 2016 Category: Neurology Source Type: research
Thrombolysis and Thrombectomy vs Thrombectomy Alone for Ischemic Stroke
This study examines whether treatment with intravenous thrombolysis before mechanical thrombectomy with a stent retriever is beneficial in patients undergoing mechanical thrombectomy.
Source: JAMA Neurology - January 9, 2017 Category: Neurology Source Type: research
Not All Middle Cerebral Artery M2 Segments Are the Same
To the Editor In the research article “Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the Middle Cerebral Artery M2 Segment,” Sarraj and colleagues describe the advantage of endovascular therapy in addition to best medical therapy for patients with acute M2 occlusions. The article does not describe the distribution of the left- and right-sided lesions. It would be of interest to know whether the overall benefits hold true regardless of lesion lateralization or whether the results are primarily driven by benefits on one side.
Source: JAMA Neurology - February 27, 2017 Category: Neurology Source Type: research
Response to Endovascular Therapy for Acute Ischemic Stroke —Reply
In Reply We thank Silver and Morelli for their interest in our article. We agree that is it always of interest to look into the side of the lesion, specifically into dominance more than right vs left. Although this was not addressed in the recent randomized clinical trials, we looked into this aspect in our initial analyses. When performing our univariate analysis, we looked at factors that independently correlated with good outcomes with endovascular therapy (EVT) as detailed in the Results section of our article and further discussed in eTable 2 in our Supplement. The side of the lesion was tested in the univariate analy...
Source: JAMA Neurology - February 27, 2017 Category: Neurology Source Type: research
Evidence-Based Management of Patent Foramen Ovale in Patients With Ischemic Stroke
This Viewpoint describes the results of 5 randomized clinical trials of devices that occlude patent foramen ovale, discusses the cerebrovascular outcomes associated with treatment, and outlines judicious use of closure procedures.
Source: JAMA Neurology - December 26, 2017 Category: Neurology Source Type: research
Safety and Efficacy of a 3-D Stent Retriever With Aspiration-Based Thrombectomy
This randomized clinical noninferiority trial assesses a novel 3-dimensional stent retriever when used in conjunction with aspiration-based mechanical thrombectomy compared with aspiration-based mechanical thrombectomy alone in patients with acute ischemic stroke.
Source: JAMA Neurology - January 2, 2018 Category: Neurology Source Type: research
Error in Table
The Research Letter titled, “Medical Specialties of Clinicians Providing Mechanical Thrombectomy to Patients with Acute Ischemic Stroke in the United States,” published in the April 2018 print issue included an error in the Table that presented the data for neurosurgeons in the row labeled “Neurology,” and the data for neurologists in the row labeled “Neurosurgery.” This included indicating that 110 thrombectomies were performed by neurosurgeons and 91 by neurologists. The Table has been corrected and now matches the data present in the main text of the article: 91 thrombectomies performed by neurosurgeons an d...
Source: JAMA Neurology - May 21, 2018 Category: Neurology Source Type: research
