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Feasibility trial of metformin XR in people with pre-diabetes and stroke (MIPPS)-randomised open blinded endpoint controlled trial
Publication date: April 2021Source: Journal of Clinical Neuroscience, Volume 86Author(s): Marjan Tabesh, Mariam Hachem, Lik-Hui Lau, Karen Borschmann, Leonid Churilov, Sarah A.L. Price, Priya Sumithran, Geoffrey Donnan, Jeffrey Zajac, Vincent Thijs, Elif I. Ekinci
Source: Journal of Clinical Neuroscience - February 3, 2021 Category: Neuroscience Source Type: research

The role of ASPECTs in patient selection for endovascular therapy – CTA source images versus noncontrast CT
In conclusion, CTA-SI ASPECTs in patient selection for ET seems to be more useful than NCCT ASPECTs. However, both scoring modalities were not found to be independent predictors of good outcome. Outcomes are changeable for the younger population who could continue their lives with mild or no deficits despite having a relatively low initial ASPECTs.
Source: Journal of Clinical Neuroscience - November 5, 2019 Category: Neuroscience Source Type: research

Carotid artery plaque detected on ultrasound is associated with impaired cognitive state in the elderly: A population-based study in Wakiso district, Uganda
This study set out to determine the prevalence of abnormal carotid ultrasound findings and their association with cognitive function among the adults ≥60 years in Wakiso district, Uganda in 2018. A total of 210 participants were included. Carotid artery stenosis, presence of plaque, stenosis and intima-media thickness were assessed by ultrasound. Cognitive status was assessed using a Mini Mental State Exam (MMSE) test. The prevalence of plaque was 21.4%. Variables which included; presence of plaque, age, education, gender, marital status, whether participant stayed alone or with someone else, care for self, occupation ...
Source: Journal of Clinical Neuroscience - July 12, 2019 Category: Neuroscience Source Type: research

Association between gender and stoke recurrence in ischemic stroke patients with high-grade carotid artery stenosis
In conclusion, male gender is associated with increased risk of recurrent ischemic stroke in patients with high-grade ICA stenosis during 5-year follow-up. Further prospective trial to assess whether male gender may benefit from more aggressive vascular risk factors control and treatment strategies for stroke prevention is warranted.
Source: Journal of Clinical Neuroscience - June 17, 2019 Category: Neuroscience Source Type: research

Mechanical thrombectomy for recurrent large vessel occlusion
Publication date: Available online 18 May 2019Source: Journal of Clinical NeuroscienceAuthor(s): P. Bhogal, M. AlMatter, V. Hellstern, M. Aguilar Pérez, O. Ganslandt, H. Bäzner, H. HenkesAbstractAlthough mechanical thrombectomy (MT) has been shown in numerous trials to be a successful treatment option for patients with large vessel occlusion (LVO), there is limited information on the safety and effectiveness of the technique in cases of recurrent LVO. To this end, we performed a retrospective review of our prospectively maintained database to identify all patients that had undergone more than one MT procedure January 200...
Source: Journal of Clinical Neuroscience - May 19, 2019 Category: Neuroscience Source Type: research

Impact of risk factors for recurrence after the first ischemic stroke in adults: A systematic review and meta-analysis
Publication date: Available online 16 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Shengbang Zheng, Baodong YaoAbstractRisk factors for first-ever stroke have been studied extensively, while those for recurrent stroke are not accurately understood. To provide the adequate secondary prevention for the patients, it is necessary to reveal the risk factors that dominate recurrent stroke. Multiple databases were adopted to search for the relevant studies and full-text articles involving in the risk factors for stroke recurrence were reviewed. Meta-analyses were performed with Review Manager 5.0 to estimate the...
Source: Journal of Clinical Neuroscience - October 17, 2018 Category: Neuroscience Source Type: research

Changing paradigm in the management of elderly patients with intracranial aneurysms: An institutional review
Publication date: Available online 7 June 2017 Source:Journal of Clinical Neuroscience Author(s): Oleg Y. Chernyshev, Shyamal C. Bir, Tanmoy K. Maiti, Devi Prasad Patra, Cesar Liendo, Hugo Cuellar, Alireza Minagar, Anil Nanda Optimal treatment of intracranial aneurysms (IAs) in elderly patients has not yet been well established. We have investigated the clinical and radiological outcomes and predictors of unfavorable outcome of IAs in elderly patients. Radiological and clinical data of 85 elderly patients from 2010 through 2015 were retrospectively reviewed. Significant differences between the groups were determined by a ...
Source: Journal of Clinical Neuroscience - June 7, 2017 Category: Neuroscience Source Type: research

Tibial somatosensory evoked potential can prognosticate for ambulatory function in subacute hemiplegic stroke
Publication date: Available online 5 January 2016 Source:Journal of Clinical Neuroscience Author(s): Pyoungsik Hwang, Min Kyun Sohn, Cuk-Seong Kim, Sungju Jee Early prediction of expected recovery in stroke can help in planning appropriate medical and rehabilitation interventions. Recovery of ambulation is one of the essential endpoints in stroke rehabilitation. However, the correlation of somatosensory evoked potentials (SSEP) with clinical parameters and their predictive significance are not clearly defined. We aimed to examine the association between tibial nerve SSEP and ambulatory outcomes in subacute hemiplegic...
Source: Journal of Clinical Neuroscience - January 11, 2016 Category: Neuroscience Source Type: research

Meta-analysis of telemonitoring to improve HbA1c levels: Promise for stroke survivors
Publication date: May 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 5 Author(s): Bryan A Lieber , Blake Taylor , Geoff Appelboom , Kiran Prasad , Sam Bruce , Annie Yang , Eliza Bruce , Brandon Christophe , E. Sander Connolly Jr. Monitoring glycemic control is useful not only in the primary prevention of stroke in diabetics, but also in the rehabilitation from and secondary prevention of stroke. In an often functionally and neurocognitively impaired population, however, poor compliance with treatment regimens is a major problem. Wireless, telemonitoring glucometers – often integrated into the patient’...
Source: Journal of Clinical Neuroscience - April 28, 2015 Category: Neuroscience Source Type: research

Association between hemoglobin A1C levels and clinical outcome in ischemic stroke patients with or without diabetes
We examined whether chronic hyperglycemia, measured in terms of hemoglobin A1C (HbA1C) levels, influences clinical outcomes after acute ischemic stroke. We prospectively and consecutively included patients admitted within 7days of ischemic stroke onset. Demographic and clinical information and outcomes were analyzed separately for patients with or without diabetes in order to identify associations with HbA1C tercile. A total of 1351 patients without diabetes and 526 with diabetes were included. The risk of mortality and poor outcome showed a tendency to increase with increasing HbA1C tercile in both groups. Rates of mortal...
Source: Journal of Clinical Neuroscience - February 16, 2015 Category: Neuroscience Source Type: research