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Source: Canadian Journal of Cardiology
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Total 265 results found since Jan 2013.
Outcomes Among Clopidogrel, Prasugrel, and Ticagrelor in ST-Elevation Myocardial Infarction Patients Who Underwent Primary Percutaneous Coronary Intervention From the TOTAL Trial
ConclusionsIn this observational analysis of STEMI patients who underwent primary percutaneous coronary intervention, ticagrelor was associated with improved outcomes compared with clopidogrel and prasugrel. An appropriately powered randomized trial is needed to confirm these findings.RésuméContexteIl n’existe pas d’analyse robuste comparant les inhibiteurs P2Y12 à prise orale (clopidogrel, prasugrel et ticagrélor) chez les patients ayant subi un infarctus du myocarde avec élévation du segment ST (STEMI) traités par une intervention coronaire percutanée (ICP) primaire. Nous avons entrepris d’évaluer les rés...
Source: Canadian Journal of Cardiology - October 9, 2019 Category: Cardiology Source Type: research
Medical Management of LVAD Patients: A Practical Guide for the Non-Expert Clinician
This article provides a concise overview of the medical management of LVAD patients aimed for non-expert clinicians. Our presentation includes the basics of LVAD physiology, design and operation, patient selection, patient assessment, medical management, adverse event identification and management, multidisciplinary care, and management of special circumstances such as non-cardiac surgery, cardiac arrest, and end-of-life care. The clinical examination of LVAD patients is unique in terms of blood-pressure and heart-rate assessment, LVAD ‘hum’ auscultation, driveline/insertion-site inspection, and device-parameter record...
Source: Canadian Journal of Cardiology - October 5, 2019 Category: Cardiology Source Type: research
Bleeding tolerance among patients with atrial fibrillation on oral anticoagulation
ConclusionsThe key determinants of the Bleeding Ratio among anticoagulated AF patients are age, prior thromboembolic and bleeding episodes. The study could support identification of AF patients who need additional effort to increase their acceptance of a life-long OAC therapy.
Source: Canadian Journal of Cardiology - September 18, 2019 Category: Cardiology Source Type: research
Flow, Reflected by Stroke Volume Index, is a Risk Marker in High Gradient Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Replacement
ConclusionsSVi can further characterise patients with HG-AS and may help to identify those who are at increased risk following TAVR.
Source: Canadian Journal of Cardiology - August 30, 2019 Category: Cardiology Source Type: research
Peritonitis affects the relationship between low-density lipoprotein cholesterol and cardiovascular events in peritoneal dialysis patients
ConclusionsPD patients with lower baseline LDL-C had a higher risk of peritonitis. The effect of LDL-C on CV events and mortality was different by the presence of peritonitis events.
Source: Canadian Journal of Cardiology - August 30, 2019 Category: Cardiology Source Type: research
Glomerular Filtration Rate-Specific Cutoffs Can Refine the Prognostic Value of Circulating Cardiac Biomarkers in Advanced Chronic Kidney Disease
ConclusionsAmong asymptomatic patients with advanced chronic kidney disease, optimal cutoffs for hs-cTnT and NT-proBNP differed according to GFR level and outperformed standard cutoffs for discrimination of cardiovascular risk.RésuméContexteÀ l’aune des valeurs seuils standard établies chez les adultes en bonne santé, on constate que les taux de troponines cardiaques hypersensibles et de propeptide natriurétique de type B N-Terminal (NT-proBNP) sont fréquemment élevés chez les patients présentant un débit de filtration glomérulaire (DFG) réduit. Les implications de cette observation restent à élucider. Nou...
Source: Canadian Journal of Cardiology - August 30, 2019 Category: Cardiology Source Type: research
Antithrombotic Management Following Transcatheter Aortic Valve Replacement: A Survey of Canadian Physicians
Publication date: Available online 22 August 2019Source: Canadian Journal of CardiologyAuthor(s): Seleman Reza Bsc, Natalia Pinilla, Emilie P. Belley-Côté, Kevin J. Um, Serena Sibilio, Madhu K. Natarajan, Richard P. WhitlockAbstractOptimal post-procedural antithrombotic regimen is uncertain after transcatheter aortic valve replacement (TAVR). We developed an online questionnaire on post-TAVR antithrombotic management. After research ethics board approval, we distributed the survey to TAVR implanters across Canada. A total of 24 TAVR implanters from 17 centres responded to the survey for a response rate of 75%. Dual antip...
Source: Canadian Journal of Cardiology - August 22, 2019 Category: Cardiology Source Type: research
Clot lysis time predicts stroke during anticoagulant therapy in patients with atrial fibrillation
ConclusionsImpaired fibrinolysis may predict thromboembolic events in AF patients receiving VKA.
Source: Canadian Journal of Cardiology - August 8, 2019 Category: Cardiology Source Type: research
Self-Reported Daytime Sleepiness and Sleep-Disordered Breathing in Patients with Atrial Fibrillation: SNOozE-AF
ConclusionsIn an ambulatory AF population, SDB was common but most patients reported low daytime sleepiness levels. Clinical features, rather than daytime sleepiness, were predictive of patients with moderate-to-severe SDB. Lack of excessive daytime sleepiness should not preclude patients from being investigated for the potential presence of concomitant SDB
Source: Canadian Journal of Cardiology - August 2, 2019 Category: Cardiology Source Type: research
Arrhythmias in Adults with Congenital Heart Disease: What the Practicing Cardiologist Needs to Know
Publication date: Available online 16 July 2019Source: Canadian Journal of CardiologyAuthor(s): Paul KhairyAbstractThe expanding population of adults with congenital heart disease (CHD) combined with the pervasiveness of arrhythmias has resulted in the rapid growth of a dedicated sector of cardiology at the intersection between two subspecialties: electrophysiology and adult CHD. Herein, practical considerations are offered regarding urgent referral for catheter ablation of atrial arrhythmias, anticoagulation, and primary prevention implantable cardioverter-defibrillators (ICDs). Patients with Ebstein anomaly and ventricul...
Source: Canadian Journal of Cardiology - July 17, 2019 Category: Cardiology Source Type: research
Anticoagulation in Patients with Advanced Chronic Kidney Disease: Walking the Fine Line between Benefit and Harm
Publication date: Available online 11 July 2019Source: Canadian Journal of CardiologyAuthor(s): Januvi Jegatheswaran, Gregory L. Hundemer, David Massicotte-Azarniouch, Manish M. SoodAbstractChronic kidney disease affects over 3 million Canadians and is highly associated with cardiovascular diseases that require anticoagulation, such as atrial fibrillation and venous thromboembolism. Patients with chronic kidney disease are at a problematic crossroads; they are at high risk of both thrombotic conditions requiring anticoagulation and bleeding complications due to anticoagulation. The limited high-quality clinical evidence to...
Source: Canadian Journal of Cardiology - July 12, 2019 Category: Cardiology Source Type: research
Perioperative Atrial Fibrillation in Non-Cardiac Surgeries for Malignancies and One-Year Recurrence
ConclusionsAF recurs in approximately thirty percent of POAF patients with malignancy in the subsequent year; most recurrences are asymptomatic.
Source: Canadian Journal of Cardiology - July 12, 2019 Category: Cardiology Source Type: research
Acute Myocardial Infarction in Severe Mental Illness: Prevalence, Clinical Outcomes, and Process of Care in U.S. Hospitalizations
ConclusionSchizophrenia and ONOP are the only SMI subtypes associated with adverse clinical outcomes after AMI. However, all patients with SMI were less likely to receive invasive management for AMI, with female gender and schizophrenia diagnosis being the strongest predictors of conservative management. A multidisciplinary approach between psychiatrists and cardiologists could improve the outcomes of this high-risk population.RésuméContexteLe trouble mental grave (TMG) est associé à une augmentation de la mortalité cardiovasculaire. Nous avons étudié la prévalence des patients atteints d’un TMG qui avaient subi ...
Source: Canadian Journal of Cardiology - July 8, 2019 Category: Cardiology Source Type: research
GFR-specific cut-offs can refine the prognostic value of circulating cardiac biomarkers in advanced chronic kidney disease
ConclusionsAmong asymptomatic patients with advanced CKD, optimal cut-offs for hs-cTnT and NT-proBNP differed by GFR level and out-performed standard cut-offs for discrimination of cardiovascular risk.
Source: Canadian Journal of Cardiology - June 22, 2019 Category: Cardiology Source Type: research
Periprocedural Anticoagulation for Cardioversion of Acute Onset Atrial Fibrillation and Flutter: Evidence Base for Current Guidelines
Publication date: Available online 12 June 2019Source: Canadian Journal of CardiologyAuthor(s): Jason G. Andrade, L. Brent MitchellABSTRACTThe practice of electrical or pharmacological cardioversion (CV) to restore sinus rhythm in patents with symptomatic atrial fibrillation (AF) or atrial flutter (AFL) has been a part of clinical practice for over 100 years. For almost as long as CV has been performed, it has been recognised that the act of restoring sinus rhythm is associated with an increased risk of stroke and systemic embolism, and that oral anticoagulation (OAC) therapy can be used to prevent peri-CV thromboembolism....
Source: Canadian Journal of Cardiology - June 13, 2019 Category: Cardiology Source Type: research
