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Source: Canadian Journal of Cardiology
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Total 265 results found since Jan 2013.
Weight Loss Is a Useful Therapeutic Objective
Publication date: February 2015 Source:Canadian Journal of Cardiology, Volume 31, Issue 2 Author(s): Caroline K. Kramer Overweight/obesity has been associated with increased risk for several conditions, including hypertension, hypercholesterolemia, diabetes mellitus, heart disease, and stroke. The morbidity associated with overweight and obesity translates into excess mortality risk, which is observed even when increased weight is not associated with metabolic abnormalities. The achievement of moderate weight loss, regardless of the treatment strategy, is associated with favorable clinical outcomes, including significant...
Source: Canadian Journal of Cardiology - February 6, 2015 Category: Cardiology Source Type: research
Using the CHA2DS2-VASc score for stroke prevention in atrial fibrillation: A focus on vascular disease, females and simple practical application
Publication date: Available online 31 January 2015 Source:Canadian Journal of Cardiology Author(s): Peter Brønnum Nielsen , Flemming Skjøth , Lars Hvilsted Rasmussen , Torben Bjerregaard Larsen , Gregory Y.H. Lip
Source: Canadian Journal of Cardiology - February 6, 2015 Category: Cardiology Source Type: research
Comparison of Dual Antiplatelet Therapy to Mono-antiplatelet Therapy Post-transcatheter Aortic Valve Implantation: Systematic review and Meta-analysis
Conclusion DAPT in comparison to MAPT in patients who have undergone TAVI demonstrated no benefit in reduction of ischemic events, with a trend towards increased harm due to bleeding. Future considerations should be given to MAPT with clopidogrel alone, as well as the omission of clopidogrel loading prior to the procedure. Teaser Post-TAVI dual antiplatelet therapy (DAPT) with ASA and clopidogrel is common practice despite the lack of clinical trial evidence demonstrating superiority over mono-antiplatelet therapy (MAPT) alone. The results of our meta-analysis demonstrate DAPT in comparison to MAPT showed no benefit in red...
Source: Canadian Journal of Cardiology - January 24, 2015 Category: Cardiology Source Type: research
Right Ventricular Hypertrophy is Associated With Cardiovascular Events in Hypertrophic Cardiomyopathy: Evidence From Study With Magnetic Resonance
Conclusions These results suggest that HCM patients with RVH on CMR have a higher incidence of cardiovascular events than non-RVH patients. Further work is needed to confirm this observation and assess its clinical importance. Teaser Right ventricular hypertrophy (RVH) was found in 28.3% of patients with hypertrophic cardiomyopathy (HCM). Because the extent of RVH significantly correlated with left ventricular mass index, not with systolic pulmonary artery pressure, the RV wall could be hypertrophied in a similar manner of left ventricle irrespective of any increase in RV afterload. RVH was an independent predictor of the ...
Source: Canadian Journal of Cardiology - January 24, 2015 Category: Cardiology Source Type: research
Global Burden of Cardiovascular Disease and Stroke: Hypertension at the Core
Publication date: Available online 22 January 2015 Source:Canadian Journal of Cardiology Author(s): Daniel T. Lackland , Michael A. Weber
Source: Canadian Journal of Cardiology - January 23, 2015 Category: Cardiology Source Type: research
Impact of nocturnal intermittent hypoxia on left atrial appendage flow velocity in atrial fibrillation
Conclusions Nocturnal intermittent hypoxia was an independent determinant for low LAA flow velocity in patients with AF, suggesting that the connection between SDB and LAA function might underlie the association of AF with stroke.
Source: Canadian Journal of Cardiology - January 17, 2015 Category: Cardiology Source Type: research
Overnight Effects of Obstructive Sleep Apnea and Its Treatment on Stroke Volume in Patients with Heart Failure
Conclusions In patients with HF, co-existing OSA causes overnight declines in SV and CO that are prevented through reversal of OSA by CPAP.
Source: Canadian Journal of Cardiology - January 17, 2015 Category: Cardiology Source Type: research
Atrial Fibrillation Patients Categorized as “Not for Anticoagulation” According to the 2014 Canadian Cardiovascular Society Algorithm Are Not “Low Risk”
Conclusions Based on the 2014 CCS algorithm, the “OAC not recommended” subgroup can have a high 1-year stroke rate overall, showing that such patients are not “low risk.” Use of the ESC guideline approach (based on the CHA2DS2-VASc) offers refinement of stroke risk stratification in such patients.
Source: Canadian Journal of Cardiology - January 17, 2015 Category: Cardiology Source Type: research
Right Atrial Volume Is Superior to Left Atrial Volume for Prediction of Atrial Fibrillation Recurrence After Direct Current Cardioversion
Conclusions RAVI is superior to LAVI for the prediction of AF recurrence at 6 months after DCCV.
Source: Canadian Journal of Cardiology - January 17, 2015 Category: Cardiology Source Type: research
Sutureless Aortic Valve Replacement: A Canadian Multicentre Study
Conclusions Sutureless AVR using the Perceval S prosthesis is safe and reproducible and results in short operative times. Echocardiographic results are encouraging, with low gradients and no paravalvular aortic insufficiency. However, in this series, sutureless AVR was associated with a high risk of permanent pacemaker implantation.
Source: Canadian Journal of Cardiology - January 17, 2015 Category: Cardiology Source Type: research
Troponin Rise in non-Acute Coronary Syndrome Hospitalized Patients: Retrospective Assessment of Outcomes and Predictors
Conclusions Unlike published literature, our study includes a variety of both operative and non-operative clinical settings associated with troponin elevation. We illustrate that although overall mortality is high after Type II MI, the majority of mortality is non-cardiovascular. Teaser Troponin elevations, in the absence of primary thrombotic acute coronary syndrome (ACS), are a common clinical occurrence and are associated with worsened overall prognosis. Our study illustrates that troponin elevations in non-ACS settings are associated with increased non-cardiovascular mortality. Additionally, older age, impaired renal f...
Source: Canadian Journal of Cardiology - December 11, 2014 Category: Cardiology Source Type: research
Association of inflammatory and hemostatic markers with stroke and thromboembolic event in atrial fibrillation: a systematic review and meta-analysis
Conclusions In conclusion, increased circulating PAI-1 and TAT levels were significantly associated with subsequent stroke in patients with AF, and D-dimer was associated with thromboembolic events in AF. Further epidemiological studies are needed to accumulate more evidence on the prognostic role of inflammatory and hemostatic markers in AF. Teaser The prognostic value of inflammatory and hemostatic markers in atrial fibrillation (AF) remains inconclusive. We conducted a systematic review and meta-analysis to evaluate the association of inflammatory and hemostatic markers with stroke and thromboembolic events in patients ...
Source: Canadian Journal of Cardiology - December 10, 2014 Category: Cardiology Source Type: research
Cost Implication of an Early Invasive Strategy on Weekdays and Weekends in Patients with Acute Coronary Syndromes
Conclusion Early invasive strategy was cost-saving, even on weekends, for Canadian NTSE-ACS patients due to significant LOS savings. Given many high-risk NSTE-ACS patients receive delayed intervention due to weekend catheterization lab status, these findings support opening catheterization labs on weekends to facilitate the use of early invasive intervention. Teaser Early invasive intervention is similar to a delayed invasive approach for prevention of cardiovascular death, MI or stroke, but in higher risk patients, it is a superior strategy. This study evaluates the costs of these strategies in Canadian patients with NSTE...
Source: Canadian Journal of Cardiology - December 9, 2014 Category: Cardiology Source Type: research
Excellent Outcomes for Transcatheter Aortic Valve Replacement Within 1 Year of Opening a Low-Volume Centre and Consideration of Requirements
Conclusions Excellent outcomes can be achieved in newly initiated relatively low-volume centres, which compares favorably to previously published large series. Important considerations include appropriate team training, rigorous patient screening, use of multimodality imaging techniques, a heart team approach, constant integration of lessons learned from larger published experiences, and maintaining a recommended minimum volume of 25 cases per year.
Source: Canadian Journal of Cardiology - December 9, 2014 Category: Cardiology Source Type: research
Risk Stratification and Clinical Pathways to Optimize Length of Stay After Transcatheter Aortic Valve Replacement
Conclusions Excellent outcomes and decreased length of stay can be achieved with individualized risk stratification to select the optimal periprocedural practice and determine the timing of discharge. These findings should be further evaluated in a large long-term clinical study.
Source: Canadian Journal of Cardiology - December 9, 2014 Category: Cardiology Source Type: research
