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Source: Journal of Neurochemistry
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Total 123 results found since Jan 2013.
MMP‐9 in Translation: From Molecule to Brain Physiology, Pathology and Therapy
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 3, 2015 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Review Source Type: research
Cannabinoid receptor type 1 agonist ACEA improves motor recovery and protects neurons in ischemic stroke in mice
Abstract
Brain ischemia produces neuronal cell death and the recruitment of pro‐inflammatory cells. In turn, the search for neuroprotection against this type of insult has rendered results involving a beneficial role of endocannabinoid receptor agonists in the Central Nervous System. In this work, to further elucidate the mechanisms associated to this neuroprotective effect, focal brain ischemia was generated by middle cerebral artery occlusion (MCAo) in C57Bl/6 mice. Three, 24 and 48 h after MCAo, animals received CB1R agonist ACEA (1 mg/kg), CB1R antagonist AM251 (1 mg/kg) or vehicle. To assess motor activity, neura...
Source: Journal of Neurochemistry - September 18, 2015 Category: Neuroscience Authors: Laura Caltana, Trinidad Maria Saez, María Paula Aronne, Alicia Brusco Tags: Original Article Source Type: research
Hypophosphorylation of Ribosomal Protein S6 is a Molecular Mechanism Underlying Ischemic Tolerance Induced by either Hibernation or Preconditioning
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Source: Journal of Neurochemistry - September 16, 2015 Category: Neuroscience Authors: Shin‐ichi Miyake, Hideaki Wakita, Joshua D. Bernstock, Paola Castri, Christl Ruetzler, Junko Miyake, Yang‐ja Lee, John M. Hallenbeck Tags: Original Article Source Type: research
Endogenous recovery after brain damage; molecular mechanisms that balance neuronal life/death fate
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Source: Journal of Neurochemistry - September 16, 2015 Category: Neuroscience Authors: Luis B. Tovar‐y‐Romo, Andrés Penagos‐Puig, Josué O. Ramírez‐Jarquín Tags: Review Source Type: research
Increased thrombin activity following reperfusion after ischemic stroke alters synaptic transmission in the hippocampus
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Source: Journal of Neurochemistry - September 1, 2015 Category: Neuroscience Authors: Doron Bushi, Marina Ben Shimon, Efrat Shavit Stein, Joab Chapman, Nicola Maggio, David Tanne Tags: Original Article Source Type: research
Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model
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Source: Journal of Neurochemistry - September 1, 2015 Category: Neuroscience Authors: Zhiwei Tang, Shiping Li, Pengcheng Han, Junxiang Yin, Yan Gan, Qingwei Liu, Jinkun Wang, Chongqian Wang, Yu Li, Jiong Shi Tags: Original Article Source Type: research
Cannabinoid receptor type 1 agonist ACEA improves motor recovery and protects neurons in ischemic stroke in mice
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - August 22, 2015 Category: Neuroscience Authors: Laura Caltana, Saez M Trinidad, María Paula Aronne, Alicia Brusco Tags: Original Article Source Type: research
Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke
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Source: Journal of Neurochemistry - July 30, 2015 Category: Neuroscience Authors: Fan Li, Joel Faustino, Moon‐Sook Woo, Nikita Derugin, Zinaida S Vexler Tags: Short Communication Source Type: research
Overactivation of NR2B‐containing NMDA receptors through entorhinal–hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion
This study indicates that early inhibition of NR2B‐containing NMDARs may represent a potential strategy to prevent or delay the occurrence of post‐stroke dementia.
Middle cerebral artery occlusion induces secondary damage in the hippocampus that is remote from primary ischemic regions. We propose that excessive activation of NR2B‐containing NMDA receptors through entorhinal–hippocampal connection initiated the accumulation of hyperphosphorylated tau in the hippocampus, which subsequently induced cognitive deficit. This study provides new insights into the prospects of NR2B inhibition in stoke therapy.
Middle cere...
Source: Journal of Neurochemistry - June 4, 2015 Category: Neuroscience Authors: Cheng‐Shi Xu, An‐Chun Liu, Juan Chen, Zhi‐Yong Pan, Qi Wan, Zhi‐Qiang Li, Ze‐Fen Wang Tags: Original Article Source Type: research
Overactivation of NR2B‐containing NMDA receptors through entorhinal‐hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion (MCAO)
This study indicates that early inhibition of NR2B‐containing NMDARs may represent a potential strategy to prevent or delay the occurrence of post‐stroke dementia.
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - April 22, 2015 Category: Neuroscience Authors: Cheng‐Shi Xu, An‐Chun Liu, Juan Chen, Zhi‐Yong Pan, Qi Wan, Zhi‐Qiang Li, Ze‐Fen Wang Tags: Original Article Source Type: research
Vinexin‐β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis
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Source: Journal of Neurochemistry - March 31, 2015 Category: Neuroscience Authors: Mingchang Li, Sen Guo, Peng Zhang, Jun Gong, Ankang Zheng, Yan Zhang, Hongliang Li Tags: Original Article Source Type: research
Issue Cover (March 2015)
Front cover: Matrigel tube formation of rat brain endothelial cells. Iron chelation and ROS inhibition abrogated lipocalin‐2‐induced tube formation (cover) and migration. Lipocalin‐2 may act as a help‐me signal for neurovascular recovery after stroke. J. Neurochem. 2015, vol. 132 (6), pp. 622–628.
Read the full article on doi: 10.1111/jnc.13023
Source: Journal of Neurochemistry - March 12, 2015 Category: Neuroscience Tags: Issue Cover Source Type: research
Microglia and neuroprotection
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Source: Journal of Neurochemistry - February 18, 2015 Category: Neuroscience Authors: Zhihong Chen, Bruce D. Trapp Tags: Review Source Type: research
A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti‐inflammatory and hypothermic effects
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - January 27, 2015 Category: Neuroscience Authors: Zhi Ruan, Hong Min Wang, Xiao Tian Huang, Yan Fu, Jian Wu, Chun Yan Ye, Jin Long Li, Lei Wu, Qi Gong, Wei Min Zhao, Hai Yan Zhang Tags: Original Article Source Type: research
S‐allyl cysteine activates the Nrf2‐dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo
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Source: Journal of Neurochemistry - November 13, 2014 Category: Neuroscience Authors: Huanying Shi, Xu Jing, Xinbing Wei, Ruth G. Perez, Manru Ren, Xiumei Zhang, Haiyan Lou Tags: Original Article Source Type: research
