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Association of Ideal Cardiovascular Health Metrics and Retinal Microvascular Findings: The Atherosclerosis Risk in Communities Study Epidemiology
Conclusions Few adults had ideal cardiovascular health. Those with the best level of health were less likely to have retinopathy signs, wide retinal venules, and narrow retinal arterioles, which are associated with increased stroke and coronary heart disease risk.
Source: JAHA:Journal of the American Heart Association - November 19, 2013 Category: Cardiology Authors: Ogagarue, E. R., Lutsey, P. L., Klein, R., Klein, B. E., Folsom, A. R. Tags: Epidemiology Source Type: research

Early Adoption of Dabigatran and Its Dosing in US Patients With Atrial Fibrillation: Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation Health Services and Outcomes Research
Conclusions Patients receiving dabigatran were younger and at a lower risk of stroke and bleeding. Patients appeared to drive switching from warfarin, whereas clinical characteristics influenced de novo start of dabigatran. These data suggest cautious early uptake of dabigatran, and more careful attention to dosing adjustments is warranted. Clinical Trial Registration URL: Clinicaltrials.gov. Unique identifier: NCT01165710.
Source: JAHA:Journal of the American Heart Association - November 25, 2013 Category: Cardiology Authors: Steinberg, B. A., Holmes, D. N., Piccini, J. P., Ansell, J., Chang, P., Fonarow, G. C., Gersh, B., Mahaffey, K. W., Kowey, P. R., Ezekowitz, M. D., Singer, D. E., Thomas, L., Peterson, E. D., Hylek, E. M., The Outcomes Registry for Better Informed Treatme Tags: Health Services and Outcomes Research Source Type: research

Haptoglobin 2-2 Genotype is Not Associated With Cardiovascular Risk in Subjects With Elevated Glycohemoglobin--Results From the Bruneck Study Genetics
Conclusions Subjects with the Hp 2-2 genotype and elevated HbA1c compared with subjects with other Hp genotypes and elevated HbA1c did not show increased CVD risk.
Source: JAHA:Journal of the American Heart Association - May 16, 2014 Category: Cardiology Authors: Pechlaner, R., Kiechl, S., Willeit, P., Demetz, E., Haun, M., Weger, S., Oberhollenzer, F., Kronenberg, F., Bonora, E., Weiss, G., Willeit, J. Tags: Genetics Source Type: research

HIV Infection and Cardiovascular Disease in Women Epidemiology
Conclusions HIV is associated with an increased risk of CVD in women.
Source: JAHA:Journal of the American Heart Association - October 16, 2014 Category: Cardiology Authors: Womack, J. A., Chang, C.-C. H., So-Armah, K. A., Alcorn, C., Baker, J. V., Brown, S. T., Budoff, M., Butt, A. A., Gibert, C., Goetz, M. B., Gottdiener, J., Gottlieb, S., Justice, A. C., Leaf, D., McGinnis, K., Rimland, D., Rodriguez-Barradas, M. C., Sico, Tags: Epidemiology Source Type: research

Electrocardiographic Deep Terminal Negativity of the P Wave in V1 and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities (ARIC) Study Coronary Heart Disease
Conclusion DTNPV1 is predictive of SCD suggesting its potential utility in risk stratification in the general population.
Source: JAHA:Journal of the American Heart Association - November 21, 2014 Category: Cardiology Authors: Tereshchenko, L. G., Henrikson, C. A., Sotoodehnia, N., Arking, D. E., Agarwal, S. K., Siscovick, D. S., Post, W. S., Solomon, S. D., Coresh, J., Josephson, M. E., Soliman, E. Z. Tags: Coronary Heart Disease Source Type: research

Abnormal Stress-Related Measures of Arterial Stiffness in Middle-Aged and Elderly Men and Women With Impaired Fasting Glucose at Risk for a First Episode of Symptomatic Heart Failure Epidemiology
Conclusion Middle- and older-aged individuals with diabetes or impaired fasting glucose have higher stress measures of arterial stiffness than those with normal fasting glucose. These data emphasize the need for future studies with larger sample sizes to determine whether stress-related elevations in arterial stiffness are related to exercise intolerance and future episodes of heart failure experienced by those with abnormalities of fasting glucose. Clinical Trial Registration URL: http://clinicaltrials.gov/. Unique identifier: NCT00542503.
Source: JAHA:Journal of the American Heart Association - January 14, 2015 Category: Cardiology Authors: Vasu, S., Morgan, T. M., Kitzman, D. W., Bertoni, A., Stacey, R. B., Hamilton, C., Chiles, C., Thohan, V., Hundley, W. G. Tags: Epidemiology Source Type: research

Asymmetric Dimethylarginine and Cardiovascular Risk: Systematic Review and Meta-Analysis of 22 Prospective Studies Epidemiology
Conclusions Available prospective studies suggest associations between circulating ADMA concentration and CVD outcomes under a broad range of circumstances. Further research is needed to better clarify these associations, particularly in large general population studies.
Source: JAHA:Journal of the American Heart Association - May 28, 2015 Category: Cardiology Authors: Willeit, P., Freitag, D. F., Laukkanen, J. A., Chowdhury, S., Gobin, R., Mayr, M., Di Angelantonio, E., Chowdhury, R. Tags: Epidemiology Source Type: research

Brain Arterial Diameters as a Risk Factor for Vascular Events Epidemiology
Conclusions The risk of death, vascular death, and any vascular event increased at both extremes of brain arterial diameters. The pathophysiology linking brain arterial remodeling to systemic vascular events needs further research.
Source: JAHA:Journal of the American Heart Association - August 6, 2015 Category: Cardiology Authors: Gutierrez, J., Cheung, K., Bagci, A., Rundek, T., Alperin, N., Sacco, R. L., Wright, C. B., Elkind, M. S. V. Tags: Epidemiology Source Type: research

Patterns of Anticoagulation Use and Cardioembolic Risk After Catheter Ablation for Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusion The overall risk of stroke in postablation patients is low; however, OAC discontinuation after ablation is common and is associated with increased risk of cardioembolism for all patients within the first 3 months and for high-risk patients in the long term. Continuing OAC for at least 3 months in all patients and indefinitely in high-risk patients appears to be the safest strategy.
Source: JAHA:Journal of the American Heart Association - November 5, 2015 Category: Cardiology Authors: Noseworthy, P. A., Yao, X., Deshmukh, A. J., Van Houten, H., Sangaralingham, L. R., Siontis, K. C., Piccini, J. P., Asirvatham, S. J., Friedman, P. A., Packer, D. L., Gersh, B. J., Shah, N. D. Tags: Arrhythmia and Electrophysiology Source Type: research

Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women Vascular Medicine
Conclusions The foremost difference in cardiovascular regulation between sexes was higher upright hemodynamic workload for the heart in men, a finding not explained by known cardiovascular risk factors or hormonal differences before menopause. Heart rate variability analyses indicated higher sympathovagal balance in men regardless of body position. The deviations in upright hemodynamics could play a role in the differences in cardiovascular risk between men and women. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01742702.
Source: JAHA:Journal of the American Heart Association - June 20, 2016 Category: Cardiology Authors: Kangas, P., Tahvanainen, A., Tikkakoski, A., Koskela, J., Uitto, M., Viik, J., Kähönen, M., Kööbi, T., Mustonen, J., Pörsti, I. Tags: Autonomic Nervous System, Clinical Studies, Hemodynamics Vascular Medicine Source Type: research

Stability of High-Quality Warfarin Anticoagulation in a Community-Based Atrial Fibrillation Cohort: The Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study Epidemiology
Conclusions Nearly 60% of AF patients with high-quality TTR1 on warfarin maintained TTR ≥70% over the next 6 months. A minority deteriorated to very poor TTR. Patient features did not strongly predict TTR in the second 6-month period. Our analyses support watchful waiting for AF patients with initial high-quality warfarin anticoagulation before considering alternative anticoagulants.
Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Dallalzadeh, L. O., Go, A. S., Chang, Y., Borowsky, L. H., Fang, M. C., Singer, D. E. Tags: Atrial Fibrillation, Epidemiology, Primary Prevention, Anticoagulants Source Type: research

Cerebral Microbleeds, Vascular Risk Factors, and Magnetic Resonance Imaging Markers: The Northern Manhattan Study Epidemiology
Conclusions CMBs may represent the severity of vascular disease in this racially and ethnically diverse cohort. Larger studies are needed to elucidate the association between diabetes medication use and CMB presence.
Source: JAHA:Journal of the American Heart Association - September 15, 2016 Category: Cardiology Authors: Caunca, M. R., Del Brutto, V., Gardener, H., Shah, N., Dequatre-Ponchelle, N., Cheung, Y. K., Elkind, M. S. V., Brown, T. R., Cordonnier, C., Sacco, R. L., Wright, C. B. Tags: Epidemiology, Race and Ethnicity Source Type: research

Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials Epidemiology
BackgroundResults from observational and genetic epidemiological studies suggest that lower serum homocysteine levels are associated with lower incidence of cardiovascular disease (CVD). Numerous randomized controlled trials have investigated the efficacy of lowering homocysteine with folic acid supplementation for CVD risk, but conflicting results have been reported.Methods and ResultsThree bibliographic databases (Medline, Embase, and the Cochrane Database of Systematic Reviews) were searched from database inception until December 1, 2015. Of the 1933 references reviewed for eligibility, 30 randomized controlled trials i...
Source: JAHA:Journal of the American Heart Association - August 14, 2016 Category: Cardiology Authors: Li, Y., Huang, T., Zheng, Y., Muka, T., Troup, J., Hu, F. B. Tags: Cardiovascular Disease, Diet and Nutrition Original Research Source Type: research

Long-Term Risk of Cardiovascular Events in Patients With Chronic Kidney Disease Who Have Survived Sepsis: A Nationwide Cohort Study Epidemiology
ConclusionsOur findings highlight the association of sepsis with a significantly increased long‐term risk of cardiovascular events among survivors in the chronic kidney disease population.
Source: JAHA:Journal of the American Heart Association - February 10, 2017 Category: Cardiology Authors: Shih, C.-J., Chao, P.-W., Ou, S.-M., Chen, Y.-T. Tags: Cardiovascular Disease, Epidemiology, Risk Factors Original Research Source Type: research

Comparison of Carotid Plaque Score and Coronary Artery Calcium Score for Predicting Cardiovascular Disease Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology
BackgroundCoronary artery calcium (CAC) predicts coronary heart disease (CHD) events better than carotid wall plaque presence; however, differences in the utility of CAC burden and carotid plaque burden across the spectrum of cardiovascular disease (CVD) events is unknown.Methods and ResultsCVD, CHD and stroke/transient ischemic attack (TIA) events were evaluated prospectively in a multiethnic cohort without CVD at baseline. Carotid plaque score was determined by the number of ultrasound‐detected plaques in the common, bifurcation, and internal carotid artery segments. CAC was detected by computed tomography. Predictive ...
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Gepner, A. D., Young, R., Delaney, J. A., Budoff, M. J., Polak, J. F., Blaha, M. J., Post, W. S., Michos, E. D., Kaufman, J., Stein, J. H. Tags: Epidemiology, Primary Prevention, Risk Factors, Computerized Tomography (CT), Magnetic Resonance Imaging (MRI) Original Research Source Type: research

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